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39.4 \u795e\u7ecf\u80f6\u8d28\u7624\u4e2d\u7684\u68c0\u67e5\u70b9\u6291\u5236\u5242<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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39.5 T\u7ec6\u80de\u6cbb\u7597<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u4e0e\u5176\u4ed6\u5b9e\u4f53\u80bf\u7624\u7c7b\u4f3c\uff0cT\u7ec6\u80de\u7597\u6cd5\u5728\u80f6\u8d28\u7624\u4e2d\u7684\u5e94\u7528\u4ecd\u5904\u4e8e\u5b9e\u9a8c\u9636\u6bb5\u3002\u65e9\u671f\u7814\u7a76\u91c7\u7528\u4ece\u5916\u5468\u8840\u5faa\u73af\u4e2d\u5206\u79bb\u7684\u975e\u7279\u5f02\u6027\u6d3b\u5316\u6dcb\u5df4\u7ec6\u80de\uff08\u5373\u6dcb\u5df4\u56e0\u5b50\u6d3b\u5316\u6740\u4f24\u7ec6\u80de\uff0cLAK\uff09\uff0c\u5e76\u5c06\u5176\u5c40\u90e8\u6ce8\u5c04\u5230\u80bf\u7624\u5207\u9664\u8154\u4e2d\uff0c\u7136\u800c\u5176\u6210\u529f\u7387\u6709\u9650\u3002\u968f\u7740\u8fd1\u5e74\u6765\u5728\u80f6\u8d28\u7624\u4e2d\u53d1\u73b0\u514d\u75ab\u539f\u6027\u65b0\u8868\u4f4d\uff08neo\u8868\u4f4d\uff09\uff0c\u4ee5\u53ca\u5728\u6dcb\u5df4\u7624\u548c\u5b9e\u4f53\u7624\u4e2d\u91c7\u7528\u7c7b\u4f3c\u7684\u6cbb\u7597\u7b56\u7565\uff0c\u7814\u7a76\u7684\u91cd\u70b9\u5df2\u7ecf\u8f6c\u5411TCR\u8f6c\u57fa\u56e0T\u7ec6\u80de\u7684\u8fc7\u7ee7\u8f6c\u79fb\u3002<\/p>\n

\u76ee\u524d\uff0c\u9776\u5411EGFRvIII\u7684CAR-T\u7ec6\u80de\u6cbb\u7597\u6b63\u5728\u80f6\u8d28\u6bcd\u7ec6\u80de\u7624\u60a3\u8005\u4e2d\u8fdb\u884c\u7814\u7a76\uff0c\u4f46\u57fa\u4e8eEGFRvIII\u75ab\u82d7\u8bd5\u9a8c\u7684\u9634\u6027\u7ed3\u679c\uff0c\u8fd9\u79cd\u6cbb\u7597\u7684\u6210\u529f\u6027\u4f9d\u7136\u503c\u5f97\u6000\u7591\u3002\u6700\u8fd1\uff0c\u4f7f\u7528\u542b\u67094-1BB\u548c\u7a81\u53d8IgG4-Fc\u8fde\u63a5\u4f53\u7684\u4fee\u9970CAR\u8f6c\u5bfcT\u7ec6\u80de\uff0c\u9776\u5411\u8bc6\u522b\u80bf\u7624\u76f8\u5173\u6297\u539fIL13R\u03b12\uff08\u767d\u7ec6\u80de\u4ecb\u7d20-13\u53d7\u4f53\u03b12\uff09\uff0c\u5728\u590d\u53d1\u6027\u80f6\u8d28\u6bcd\u7ec6\u80de\u7624\u548c\u4f34\u6709\u8f6f\u8111\u819c\u548c\u8111\u810a\u6db2\u6269\u6563\u7684\u60a3\u8005\u4e2d\u8fdb\u884c\u5c40\u90e8\u8fc7\u7ee7\u8f6c\u79fb\u6cbb\u7597\uff08NCT00730613\uff0cNCT01082926\uff09\u3002\u90e8\u5206\u60a3\u8005\u5728\u63a5\u53d7\u5c40\u90e8\u6cbb\u7597\u540e\uff0c\u51fa\u73b0\u4e86\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\u8fdc\u7aef\u75c5\u7076\u7684\u6301\u7eed\u90e8\u5206\u7f13\u89e3\u3002\u7136\u800c\uff0c\u6700\u7ec8\u7684\u80bf\u7624\u8fdb\u5c55\u8868\u660e\u514d\u75ab\u9003\u9038\u53ef\u80fd\u4e0e\u6297\u539f\u4e22\u5931\u6709\u5173\u3002<\/p>\n

\u539f\u5219\u4e0a\uff0c\u8fd9\u4e9b\u7814\u7a76\u7ed3\u679c\u6307\u51fa\u4e86\u4e24\u4e2a\u5173\u952e\u70b9\uff1a(a) \u9776\u5411\u80bf\u7624\u76f8\u5173\u6297\u539f\u662f\u6709\u6548\u7684\uff1b(b) \u5c40\u90e8\u9012\u9001\uff08\u4f8b\u5982\u901a\u8fc7\u8111\u810a\u6db2\uff09\u80fd\u591f\u6709\u6548\u5c06\u5177\u6709\u7279\u5f02\u6027\u6d3b\u6027\u7684\u6297\u539f\u7279\u5f02\u6027T\u7ec6\u80de\u9012\u9001\u81f3\u80f6\u8d28\u7624\u3002\u7136\u800c\uff0c\u662f\u5426\u5168\u8eab\u9012\u9001\u540c\u6837\u6709\u6548\uff0c\u6216\u8005\u662f\u5426\u9700\u8981\u5c40\u90e8\u9012\u9001\u6765\u514b\u670d\u8840\u8111\u5c4f\u969c\u6216\u8840\u8111\u810a\u6db2\u5c4f\u969c\uff0c\u4ecd\u9700\u8fdb\u4e00\u6b65\u7814\u7a76\u9a8c\u8bc1\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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39.6 \u9776\u5411\u514d\u75ab\u5fae\u73af\u5883\u5728\u80f6\u8d28\u7624\u4e2d\u7684\u4f5c\u7528<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u5373\u4f7f\u6709\u6548\u7684\u6297\u80bf\u7624T\u7ec6\u80de\u53cd\u5e94\u80fd\u591f\u88ab\u6210\u529f\u5f15\u5bfc\u81f3\u80f6\u8d28\u7624\u5fae\u73af\u5883\uff0c\u514d\u75ab\u6291\u5236\u6027\u8d28\u4ecd\u7136\u662f\u6700\u7ec8\u7684\u6311\u6218\u3002\u80f6\u8d28\u7624\u5fae\u73af\u5883\u4e2d\u7684\u7269\u7406\u56e0\u7d20\uff0c\u5982\u4f4epH\u503c\u548c\u7f3a\u6c27\uff0c\u7279\u522b\u662f\u5728\u80f6\u8d28\u6bcd\u7ec6\u80de\u7624\u7684\u574f\u6b7b\u533a\u548c\u4f2a\u6805\u680f\u6837\u574f\u6b7b\u533a\u57df\uff0c\u5e7f\u6cdb\u5b58\u5728\u3002\u8fd9\u4e9b\u95ee\u9898\u53ea\u80fd\u901a\u8fc7\u5728\u514d\u75ab\u6cbb\u7597\u524d\u5207\u9664\u5927\u7684\u574f\u6b7b\u80bf\u7624\u6765\u90e8\u5206\u89e3\u51b3\u3002<\/p>\n

\u5316\u7597\u8bf1\u5bfc\u7684\u7ec6\u80de\u6b7b\u4ea1\u5728\u795e\u7ecf\u80f6\u8d28\u7624\u4e2d\u5e76\u672a\u663e\u8457\u589e\u5f3a\u5176\u514d\u75ab\u539f\u6027\uff0c\u4e3b\u8981\u539f\u56e0\u662f\u80bf\u7624\u5bf9\u80fd\u591f\u8bf1\u5bfc\u514d\u75ab\u539f\u6027\u7ec6\u80de\u6b7b\u4ea1\u7684\u836f\u7269\u5177\u6709\u8010\u836f\u6027\u3002\u5176\u4ed6\u80fd\u591f\u63d0\u5347\u514d\u75ab\u539f\u6027\u7684\u6cbb\u7597\u624b\u6bb5\u5305\u62ec\u653e\u5c04\u6cbb\u7597\u548c\u75c5\u6bd2\u6cbb\u7597\u3002\u4ece\u673a\u5236\u4e0a\u8bb2\uff0c\u8fd9\u4e9b\u65b9\u6cd5\u53ef\u80fd\u901a\u8fc7\u589e\u5f3a\u6297\u539f\u5448\u9012\u3001\u8bf1\u5bfc\u8868\u4f4d\u6269\u6563\u4ee5\u53ca\u5229\u7528\u6297\u75c5\u6bd2\u514d\u75ab\u53cd\u5e94\u6765\u589e\u52a0\u5bf9\u514d\u75ab\u539f\u6027\u6297\u539f\u7684\u7efc\u5408\u514d\u75ab\u53cd\u5e94\u3002<\/p>\n

\u80f6\u8d28\u7624\u7684\u514d\u75ab\u6291\u5236\u5fae\u73af\u5883\u4e2d\uff0c\u5176\u4ed6\u5f71\u54cd\u56e0\u7d20\u8fd8\u5305\u62ec\u7ec6\u80de\u56e0\u5b50\uff08\u5982IL-10\uff09\u3001\u751f\u957f\u56e0\u5b50\uff08\u5982TGF-\u03b2\uff09\u4ee5\u53ca\u4ee3\u8c22\u4ea7\u7269\uff08\u5982\u72ac\u5c3f\u6c28\u9178\uff09\u3002\u76ee\u524d\uff0c\u8fd9\u4e9b\u514d\u75ab\u6291\u5236\u56e0\u5b50\u7684\u6291\u5236\u5242\u5df2\u88ab\u5f00\u53d1\u6216\u6b63\u5728\u7814\u53d1\u4e2d\uff0c\u7136\u800c\u5b83\u4eec\u4f5c\u4e3a\u5355\u4e00\u7597\u6cd5\u7684\u6548\u679c\u6709\u9650\u3002\u56e0\u6b64\uff0c\u5fc5\u987b\u5728\u7cbe\u5fc3\u6311\u9009\u7684\u60a3\u8005\u7fa4\u4f53\u4e2d\u8fdb\u884c\u9002\u5f53\u7684\u7ec4\u5408\u6cbb\u7597\u8bd5\u9a8c(Fig 39.1<\/span>)\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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Fig. 39.1<\/span> \u795e\u7ecf\u80bf\u7624\u5b66\u4e2d\u514d\u75ab\u6cbb\u7597\u53d1\u73b0\u548c\u7ec4\u5408\u6cbb\u7597\u65b9\u6cd5\u7684\u5de5\u4f5c\u6d41\u7a0b<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u672c\u6587\u7531Oncolab\u5fae\u4fe1\u516c\u4f17\u53f7\u7ffb\u8bd1\u6574\u7406\u81eaOncoimmunology: A Practical Guide for Cancer Immunotherapy\uff0c\u4ec5\u7528\u4e8e\u5b66\u4e60\u4ea4\u6d41\u4f7f\u7528\uff0c\u5982\u9700\u8d2d\u4e70\u539f\u7248\u4e66\u7c4d\u53ef\u70b9\u51fb\u9605\u8bfb\u539f\u6587\u8d2d\u4e70\u3002<\/span>
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\u2014 THE  END \u2014<\/span><\/p>\n


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\u6765\u6e90 | Oncoimmunology: A Practical Guide <\/span><\/p>\n

for Cancer Immunotherapy<\/span><\/p>\n

\u521d\u7a3f\u7ffb\u8bd1 | \u4efb\u632f\u9633<\/span><\/p>\n

\u56fe\u6587\u6392\u7248 | \u90ed\u9707\u8fdc \u9ea6\u601d\u6dcb<\/span><\/span><\/p>\n

\u5ba1\u6838\u4fee\u6539 | \u738b\u5764<\/span><\/p>\n

\uff08\u8f6c\u8f7d\u8bf7\u4fdd\u7559\u6b64\u90e8\u5206\u5185\u5bb9\uff09<\/span><\/strong><\/p>\n


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\u2589  \u5f80\u671f\u63a8\u9001\u5408\u8f91<\/strong><\/strong><\/section>\n
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\u80bf\u7624\u514d\u75ab\u5b66\u6700\u65b0\u6587\u732e<\/span><\/a>
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\u53ef\u4ee5\u67e5\u8be22024\u5e74\u6700\u65b0SCI\u671f\u520a\u5f71\u54cd\u56e0\u5b50\u53ca\u5206\u533a\u5566\uff01<\/span><\/a>
\u514d\u75ab\u5b66\u62fe\u9057\u7cfb\u5217<\/span><\/a><\/p>\n

\u80bf\u7624\u514d\u75ab\u5b66\u7cfb\u5217<\/span><\/a><\/p>\n

\u795e\u7ecf\u79d1\u5b66\u539f\u7406\u7cfb\u5217<\/span><\/a><\/p>\n

ACIR\u6587\u732e\u901f\u9012<\/span><\/a><\/p>\n

SCI\u8bba\u6587\u4f5c\u56fe<\/span><\/a><\/p>\n

SCI\u8bba\u6587\u5199\u4f5c\u53ca\u6295\u7a3f<\/span><\/a><\/p>\n

\u751f\u4fe1\u5165\u95e8\u5b66\u4e60\u7b14\u8bb0<\/span><\/a><\/p>\n

R\u8bed\u8a00\u57fa\u7840\u4e0e\u5355\u7ec6\u80de\u5206\u6790\u5b9e\u6218\u89c6\u9891\u8bfe\u7a0b<\/span><\/a><\/p>\n

\u751f\u7269\u5b66\u5b9e\u9a8c\u6280\u672f\u53ca\u5e38\u7528\u8f6f\u4ef6<\/span><\/a><\/p>\n

\u5e38\u7528\u5b9e\u9a8c<\/span>\u4eea\u5668\u7b80\u4ecb\u53ca\u64cd\u4f5c\u89c6\u9891<\/span><\/a><\/span><\/p>\n

\u5e38\u7528\u7535\u8111\u8f6f\u4ef6\u4f7f\u7528\u6559\u7a0b<\/span><\/a><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u52a0\u5165\u8bfb\u8005\u4ea4\u6d41\u7fa4~<\/span><\/p>\n

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\u52a0\u5165\u77e5\u8bc6\u661f\u7403~<\/span><\/p>\n


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\u70b9\u4eae\u8d5e\u4e0e\u5728\u770b <\/span><\/p>\n

\u8ba9\u66f4\u591a\u4eba\u770b\u5230<\/span><\/p>\n

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\u672c\u7bc7\u6587\u7ae0\u6765\u6e90\u4e8e\u5fae\u4fe1\u516c\u4f17\u53f7:OncoLab<\/p>\n<\/blockquote>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

\u4e0a\u671f\u5185\u5bb9\uff1a\u80bf\u7624\u514d\u75ab\u5b66-\u7b2c39\u7ae0 \u795e\u7ecf\u80f6\u8d28\u7624\u7684\u514d\u75ab\u6cbb\u7597\uff08\u4e0a\uff09 39.4 \u795e\u7ecf\u80f6\u8d28\u7624\u4e2d\u7684\u68c0\u67e5\u70b9\u6291\u5236\u5242 \u4e34\u5e8a\u524d\u7814\u7a76\u8868\u660e\uff0c\u5355\u836f\u6cbb\u7597\u6216\u4e0e\u68c0\u67e5\u70b9\u6291\u5236\u5242\u8054\u5408\u4f7f\u7528\uff0c\u80fd\u591f\u6709\u6548\u6839\u9664\u5df2\u5efa\u7acb\u7684\u539f\u4f4d\u540c\u57fa\u56e0\u5316…<\/p>\n","protected":false},"author":1,"featured_media":5723,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[59],"tags":[],"_links":{"self":[{"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/posts\/5725"}],"collection":[{"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/comments?post=5725"}],"version-history":[{"count":0,"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/posts\/5725\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/media\/5723"}],"wp:attachment":[{"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/media?parent=5725"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/categories?post=5725"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/tags?post=5725"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}