{"id":5730,"date":"2024-09-20T16:59:36","date_gmt":"2024-09-20T08:59:36","guid":{"rendered":"http:\/\/dh.oncolab.cn\/index.php\/2024\/09\/20\/%e8%82%bf%e7%98%a4%e5%85%8d%e7%96%ab%e5%ad%a6-%e7%ac%ac40%e7%ab%a0-%e8%af%84%e4%bc%b0t%e7%bb%86%e8%83%9e%e5%8f%97%e4%bd%93%e7%9a%84%e4%ba%b2%e5%92%8c%e5%8a%9b%e5%8f%8a%e9%92%88%e5%af%b9%e8%82%bf\/"},"modified":"2024-09-20T16:59:36","modified_gmt":"2024-09-20T08:59:36","slug":"%e8%82%bf%e7%98%a4%e5%85%8d%e7%96%ab%e5%ad%a6-%e7%ac%ac40%e7%ab%a0-%e8%af%84%e4%bc%b0t%e7%bb%86%e8%83%9e%e5%8f%97%e4%bd%93%e7%9a%84%e4%ba%b2%e5%92%8c%e5%8a%9b%e5%8f%8a%e9%92%88%e5%af%b9%e8%82%bf","status":"publish","type":"post","link":"http:\/\/dh.oncolab.cn\/index.php\/2024\/09\/20\/%e8%82%bf%e7%98%a4%e5%85%8d%e7%96%ab%e5%ad%a6-%e7%ac%ac40%e7%ab%a0-%e8%af%84%e4%bc%b0t%e7%bb%86%e8%83%9e%e5%8f%97%e4%bd%93%e7%9a%84%e4%ba%b2%e5%92%8c%e5%8a%9b%e5%8f%8a%e9%92%88%e5%af%b9%e8%82%bf\/","title":{"rendered":"\u80bf\u7624\u514d\u75ab\u5b66-\u7b2c40\u7ae0 \u8bc4\u4f30T\u7ec6\u80de\u53d7\u4f53\u7684\u4eb2\u548c\u529b\u53ca\u9488\u5bf9\u80bf\u7624\u6297\u539f\u7684\u4eb2\u548c\u5ea6(\u4e0a\uff09"},"content":{"rendered":"
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40.1 \u6cbb\u7597\u6076\u6027\u75be\u75c5\u7684T\u7ec6\u80de\u7597\u6cd5<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u7ec6\u80de\u6bd2\u6027CD8 T\u7ec6\u80de\u4e0d\u4ec5\u5728\u62b5\u5fa1\u591a\u79cd\u4f20\u67d3\u75c5\u4e2d\u53d1\u6325\u5173\u952e\u4f5c\u7528\uff0c\u8fd1\u5e74\u6765\u7684\u7814\u7a76\u8868\u660e\uff0c\u5b83\u4eec\u540c\u6837\u53ef\u4ee5\u6709\u6548\u6e05\u9664\u80bf\u7624\u7ec6\u80de\u3002\u764c\u75c7\u514d\u75ab\u53cd\u5e94\u7684\u6838\u5fc3\u5728\u4e8e\u8868\u8fbe\u80bf\u7624\u7279\u5f02\u6027T\u7ec6\u80de\u53d7\u4f53\uff08TCR\uff09\u7684T\u7ec6\u80de\uff0c\u8fd9\u4e9bT\u7ec6\u80de\u80fd\u591f\u7cbe\u51c6\u8bc6\u522b\u5e76\u6467\u6bc1\u6076\u6027\u7ec6\u80de\u3002\u514d\u75ab\u7597\u6cd5\u7684\u76ee\u6807\u662f\u9ad8\u5ea6\u7279\u5f02\u6027\u5730\u6fc0\u6d3b\u673a\u4f53\u7684\u514d\u75ab\u7ec6\u80de\uff0c\u4e0e\u80bf\u7624\u7ec6\u80de\u5c55\u5f00\u6218\u6597\u3002<\/p>\n

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\u5176\u6b21\uff0c\u88ab\u52a8\u514d\u75ab\uff08\u6216\u8fc7\u7ee7\u6027\u7ec6\u80de\u8f6c\u79fb\uff09\u901a\u8fc7\u4ece\u764c\u75c7\u60a3\u8005\u4f53\u5185\u5206\u79bb\u81ea\u4f53\u5916\u5468\u8840\u5355\u4e2a\u6838\u7ec6\u80de\uff08PBMCs\uff09\u6216\u80bf\u7624\u6d78\u6da6\u6dcb\u5df4\u7ec6\u80de\uff08TILs\uff09\uff0c\u5728\u4f53\u5916\u8fdb\u884c\u6269\u589e\u548c\u7b5b\u9009\u80bf\u7624\u53cd\u5e94\u6027\u7ec6\u80de\uff0c\u7136\u540e\u5c06\u8fd9\u4e9b\u7ec6\u80de\u56de\u8f93\u81f3\u60a3\u8005\u4f53\u5185\u3002\u5728\u7ec6\u80de\u56de\u8f93\u524d\uff0c\u57fa\u56e0\u6539\u9020T\u7ec6\u80de\uff0c\u4f8b\u5982\u63d2\u5165TCR\u6216\u5d4c\u5408\u6297\u539f\u53d7\u4f53\uff08CARs\uff09\uff0c\u53ef\u4ee5\u663e\u8457\u63d0\u9ad8\u6cbb\u7597\u6548\u679c\u3002<\/p>\n

\u6700\u540e\uff0c\u514d\u75ab\u8c03\u8282\u53ef\u4ee5\u901a\u8fc7\u9776\u5411\u6291\u5236T\u7ec6\u80de\u529f\u80fd\u7684\u5171\u6291\u5236\u53d7\u4f53\u5b9e\u73b0\u3002\u4f8b\u5982\uff0c\u5355\u514b\u9686\u6297\u4f53Ipilimumab\uff08Yervoy\u00ae\uff09\u80fd\u591f\u963b\u65adT\u7ec6\u80de\u8868\u9762\u7684CTLA-4\u6291\u5236\u6027\u53d7\u4f53\uff0c\u5728\u4e34\u5e8a\u4e0a\u663e\u8457\u6539\u5584\u4e86\u8f6c\u79fb\u6027\u9ed1\u8272\u7d20\u7624\u60a3\u8005\u7684\u9884\u540e\u3002\u6700\u8fd1\uff0c\u6297PD-1\u6297\u4f53\u6216\u5176\u914d\u4f53PD-L1\u6297\u4f53\uff0c\u5355\u72ec\u6216\u4e0eIpilimumab\u8054\u5408\u4f7f\u7528\uff0c\u5df2\u5728\u9ed1\u8272\u7d20\u7624\u3001\u80be\u764c\u548c\u80ba\u764c\u60a3\u8005\u4e2d\u663e\u793a\u51fa\u663e\u8457\u7684\u4e34\u5e8a\u76ca\u5904\u3002<\/p>\n

\u603b\u7684\u6765\u8bf4\uff0c\u8fd9\u4e9b\u8fdb\u5c55\u8868\u660e\uff0cT\u7ec6\u80de\u5728\u5bf9\u6297\u6076\u6027\u7ec6\u80de\u7684\u514d\u75ab\u53cd\u5e94\u4e2d\u626e\u6f14\u4e86\u5173\u952e\u4e14\u6301\u4e45\u7684\u89d2\u8272\u3002\u73b0\u9636\u6bb5\uff0c\u786e\u5b9a\u54ea\u4e9bT\u7ec6\u80de\u7279\u6027\u5bf9\u4e8e\u5b9e\u73b0\u4e34\u5e8a\u7597\u6548\u81f3\u5173\u91cd\u8981\u5c24\u4e3a\u5173\u952e\u3002\u5728\u672c\u7ae0\u4e2d\uff0c\u6211\u4eec\u5c06\u7279\u522b\u5173\u6ce8TCR\u4e0epMHC\u7ed3\u5408\u7684\u76f8\u4e92\u4f5c\u7528\uff0c\u8fd9\u88ab\u8ba4\u4e3a\u662fT\u7ec6\u80de\u4ecb\u5bfc\u4fdd\u62a4\u6027\u514d\u75ab\u53cd\u5e94\u7684\u5173\u952e\u53c2\u6570\uff0c\u5e76\u56de\u987e\u8bc4\u4f30\u8fd9\u79cd\u76f8\u4e92\u4f5c\u7528\u7684\u4e0d\u540c\u6280\u672f\u624b\u6bb5\uff0c\u4ece\u800c\u5e2e\u52a9\u8bc6\u522b\u6700\u5177\u529f\u80fd\u76f8\u5173\u6027\u7684T\u7ec6\u80de\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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40.2 \u5b9a\u4e49T\u7ec6\u80de\u529f\u80fd\u6d3b\u6027\u53caTCR\u7ed3\u5408\u4eb2\u548c\u529b\u548c\u4eb2\u548c\u5ea6<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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T\u7ec6\u80de\u529f\u80fd\u4eb2\u548c\u529b\u5df2\u591a\u6b21\u88ab\u8bc1\u660e\u4e0eT\u7ec6\u80de\u7684\u4fdd\u62a4\u6548\u5e94\u76f8\u5173\uff0c\u662f\u8861\u91cfT\u7ec6\u80de\u8bc6\u522b\u540c\u6e90\u6297\u539f\u80fd\u529b\u7684\u5173\u952e\u751f\u7269\u5b66\u6307\u6807\u3002\u901a\u8fc7\u4f53\u5916\u5b9a\u91cf\u8bc4\u4f30\uff0cT\u7ec6\u80de\u5728\u9010\u6e10\u589e\u52a0\u7684\u6297\u539f\u80bd\u5242\u91cf\u4e0b\u7684\u529f\u80fd\u53cd\u5e94\uff08\u5982\u7ec6\u80de\u6bd2\u6027\u6d3b\u6027\u3001IFN-\u03b3\u4ea7\u751f\u6216\u589e\u6b96\uff09\u53ef\u4ee5\u88ab\u6d4b\u91cf\uff0c\u5e76\u901a\u8fc7\u8bf1\u5bfc\u534a\u6570\u6700\u5927\u53cd\u5e94\u7684\u80bd\u6d53\u5ea6\uff08EC50\uff09\u6765\u8fdb\u884c\u91cf\u5316\uff08\u89c1Fig 40.1a<\/span>\uff09\u3002<\/p>\n

20\u591a\u5e74\u524d\uff0cSpeiser\u53ca\u5176\u540c\u4e8b\u5f00\u521b\u6027\u5730\u8bc1\u660e\u4e86\u4f4e\u529f\u80fd\u4eb2\u548c\u529b\u7684T\u7ec6\u80de\u867d\u7136\u53ef\u4ee5\u5728\u4f53\u5916\u4fc3\u8fdb\u589e\u6b96\u6216\u7ec6\u80de\u6bd2\u6027\uff0c\u4f46\u5728\u4f53\u5185\u5bf9\u75c5\u6bd2\u611f\u67d3\u7684\u53cd\u5e94\u4e2d\u8868\u73b0\u4e0d\u8db3\u3002\u4e0e\u6b64\u76f8\u5bf9\u5e94\uff0c\u76ee\u524d\u7684\u5171\u8bc6\u662f\uff0c\u5177\u6709\u66f4\u9ad8\u529f\u80fd\u4eb2\u548c\u529b\u7684CD8 T\u7ec6\u80de\u5728\u63a7\u5236\u75c5\u6bd2\u590d\u5236\u548c\u80bf\u7624\u751f\u957f\u65b9\u9762\u6bd4\u4eb2\u548c\u529b\u8f83\u4f4e\u7684T\u7ec6\u80de\u66f4\u4e3a\u6709\u6548\u3002\u7136\u800c\uff0cT\u7ec6\u80de\u529f\u80fd\u4eb2\u548c\u529b\u7684\u4f53\u5916\u8bc4\u4f30\u4ecd\u7136\u662f\u6280\u672f\u4e0a\u8017\u65f6\u4e14\u590d\u6742\u7684\u8fc7\u7a0b\u3002\u6b64\u5916\uff0c\u7531\u4e8e\u751f\u7269\/\u529f\u80fd\u6307\u6807\u7684\u56fa\u6709\u53d8\u5f02\u6027\uff0c\u5b83\u4e5f\u4e0d\u9002\u5408\u6807\u51c6\u5316\uff0c\u56e0\u6b64\u5728\u4f53\u5916\uff0c\u901a\u5e38\u4ec5\u9650\u4e8e\u4f7f\u7528\u56fa\u5b9a\u523a\u6fc0\u5242\u91cf\u8fdb\u884c\u68c0\u6d4b\uff0c\u4e14\u7f3a\u4e4f\u5bf9T\u7ec6\u80de\u8bc4\u4f30\u7684\u901a\u7528\u6807\u51c6\u3002<\/p>\n

\u57fa\u4e8e\u8fd9\u4e9b\u8003\u8651\uff0c\u6539\u5584\u5bf9T\u7ec6\u80de\u529f\u80fd\u4e0e\u4e34\u5e8a\u7597\u6548\u7684\u4e0d\u540c\u8d21\u732e\u7684\u7406\u89e3\uff0c\u5e76\u8bc6\u522b\u989d\u5916\u7684\u57fa\u4e8eT\u7ec6\u80de\u7684\u53c2\u6570\uff0c\u4ee5\u514b\u670d\u529f\u80fd\u68c0\u6d4b\u7684\u5c40\u9650\u6027\uff0c\u5df2\u6210\u4e3a\u5f53\u52a1\u4e4b\u6025\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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Fig. 40.1 <\/span>\u5b9a\u4e49\u548c\u8bc4\u4f30T\u7ec6\u80de\u529f\u80fd\u4eb2\u548c\u529b\u53caTCR-pMHC\u7ed3\u5408\u4eb2\u548c\u529b\/\u4eb2\u5408\u5ea6<\/p>\n

(a) T\u7ec6\u80de\u529f\u80fd\u4eb2\u548c\u529b\u662f\u53cd\u6620T\u7ec6\u80de\u5bf9\u6297\u539f\u7279\u5f02\u6027\u523a\u6fc0\u7684\u53cd\u5e94\u6027\u7684\u751f\u7269\u5b66\u6307\u6807\uff0c\u8bc4\u4f30\u65b9\u5f0f\u662f\u901a\u8fc7\u5b9a\u91cf\u66b4\u9732\u4e8e\u6ef4\u5b9a\u5242\u91cf\u7684\u6297\u539f\u80bd\u4e0b\u7684T\u7ec6\u80de\u53cd\u5e94\uff08\u5982\u7ec6\u80de\u6bd2\u6027\u6d3b\u6027\u3001IFN-\u03b3\u4ea7\u751f\u6216\u589e\u6b96\uff09\u3002\u5176\u4e2d\uff0cEC50\u662f\u5b9a\u4e49\u4e3a\u4ea7\u751f\u534a\u6570\u6700\u5927\u53cd\u5e94\u7684\u80bd\u6d53\u5ea6\u3002<\/p>\n

(b) TCR-pMHC\u7ed3\u5408\u4eb2\u548c\u529b\u4e0e\u4eb2\u5408\u5ea6\u5219\u662f\u63cf\u8ff0TCR\u4e0e\u6297\u539f\u4e4b\u95f4\u7684\u5355\u4f53\u6216\u591a\u805a\u4f53\u7ed3\u5408\u5f3a\u5ea6\u7684\u751f\u7269\u7269\u7406\u5b66\u6307\u6807\uff0c\u901a\u5e38\u901a\u8fc7\u8868\u9762\u7b49\u79bb\u5b50\u4f53\u5171\u632f\uff08SPR\uff09\u6216pMHC\u591a\u4ef7\u7ed3\u5408\u8bd5\u5242\u6765\u6d4b\u91cf\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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CD8 T\u7ec6\u80de\u7684\u529f\u80fd\u4eb2\u548c\u529b\u4e3b\u8981\u7531TCR\u4e0eMHC-I\u7c7b\u5206\u5b50\u6240\u5448\u9012\u7684\u6297\u539f\u80bd\uff08\u5373pMHC\uff09\u7684\u7ed3\u5408\u5f3a\u5ea6\u53ca\u5176\u52a8\u529b\u5b66\u76f8\u4e92\u4f5c\u7528\u51b3\u5b9a\u3002\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u8fd9\u79cd\u76f8\u4e92\u4f5c\u7528\u7684\u7ed3\u5408\u5f3a\u5ea6\u548c\u52a8\u529b\u5b66\u5c5e\u6027\u662f\u5f71\u54cdT\u7ec6\u80de\u751f\u7269\u5b66\u51e0\u4e4e\u6240\u6709\u65b9\u9762\u7684\u5173\u952e\u53c2\u6570\uff0c\u5305\u62ec\u80f8\u817a\u9009\u62e9\u548c\u529f\u80fd\u6709\u6548\u6027\u3002\u8fd9\u4e9b\u5c5e\u6027\u53ef\u80fd\u4e3a\u8bc4\u4f30T\u7ec6\u80de\u53cd\u5e94\u8d28\u91cf\u63d0\u4f9b\u66f4\u6709\u4ef7\u503c\u7684\u6307\u6807\u3002<\/p>\n

\u7136\u800c\uff0c\u7531\u4e8e\u6280\u672f\u9650\u5236\uff0c\u76ee\u524d\u5f88\u5c11\u80fd\u5728\u7814\u7a76\u6216\u60a3\u8005\u7684\u514d\u75ab\u76d1\u6d4b\u4e2d\u786e\u5b9aTCR-pMHC\u7ed3\u5408\u4eb2\u548c\u529b\u6216\u52a8\u529b\u5b66\uff0c\u5373\u4f7f\u5728\u9009\u62e9\u7528\u4e8e\u8fc7\u7ee7\u6027\u7ec6\u80de\u6cbb\u7597\u7684\u80bf\u7624\u6d78\u6da6T\u7ec6\u80de\u65f6\uff0c\u8fd9\u4e00\u53c2\u6570\u4e5f\u5e38\u88ab\u5ffd\u89c6\u3002TCR-pMHC\u7684\u7ed3\u5408\u76f8\u4e92\u4f5c\u7528\u53ef\u4ee5\u901a\u8fc7\u4eb2\u548c\u529b\u6216\u4eb2\u548c\u5ea6\u6765\u6d4b\u91cf\uff08\u89c1Fig 40.1b<\/span>\uff09\uff0c\u8fd9\u4e24\u8005\u90fd\u80fd\u76f4\u63a5\u5f71\u54cdT\u7ec6\u80de\u7684\u6574\u4f53\u529f\u80fd\u53cd\u5e94\u3002<\/p>\n

TCR\u7ed3\u5408\u4eb2\u548c\u529b\u662f\u6307\u5355\u4e2aTCR\u4e0e\u5355\u4e2apMHC\u590d\u5408\u7269\u7ed3\u5408\u7684\u7269\u7406\u5f3a\u5ea6\uff0c\u901a\u5e38\u901a\u8fc7\u8868\u9762\u7b49\u79bb\u5b50\u5171\u632f\uff08SPR\uff09\u6765\u6d4b\u91cf\u3002\u76f8\u53cd\uff0c\u5728\u7ec6\u80de\u73af\u5883\u4e2d\u8bc4\u4f30\u65f6\uff0cTCR\u4eb2\u548c\u5ea6\u5219\u63cf\u8ff0\u4e86TCR-pMHC\u76f8\u4e92\u4f5c\u7528\u7684\u7ed3\u5408\u5f3a\u5ea6\uff0c\u5305\u542b\u4e86\u5171\u53d7\u4f53\uff08\u5982CD8\uff09\u7684\u8d21\u732e\uff0c\u901a\u5e38\u4f7f\u7528\u91cd\u7ec4\u53ef\u6eb6\u6027pMHC\u591a\u805a\u4f53\u8fdb\u884c\u4f30\u8ba1\u3002<\/p>\n

TCR-pMHC\u7ed3\u5408\u7684\u4eb2\u548c\u529b\/\u4eb2\u548c\u5ea6\u4e0e\u89e3\u79bb\u5e73\u8861\u5e38\u6570KD\u6210\u53cd\u6bd4\uff0cKD\u5b9a\u4e49\u4e3a\u5728\u5e73\u8861\u72b6\u6001\u4e0b\uff0c\u89e3\u79bb\u901f\u7387\uff08koff\uff09\u4e0e\u7ed3\u5408\u901f\u7387\uff08kon\uff09\u7684\u6bd4\u503c\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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40.3 \u4f4e\u7ed3\u5408\u4eb2\u548c\u529b\/\u4eb2\u548c\u5ea6\u7684TCR\u4ecb\u5bfc\u7684\u80bf\u7624\u7279\u5f02\u6027T\u7ec6\u80de\u53cd\u5e94<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u5916\u5468T\u7ec6\u80de\u5e93\u7684\u591a\u6837\u6027\u901a\u8fc7\u80f8\u817a\u53d1\u80b2\u671f\u95f4TCR\u03b1\u548c\u03b2\u94fe\u7684\u968f\u673a\u4f53\u7ec6\u80de\u57fa\u56e0\u7247\u6bb5\u91cd\u6392\u6765\u5b9e\u73b0\u3002\u968f\u540e\uff0cT\u7ec6\u80de\u5e93\u901a\u8fc7\u80f8\u817a\u5185\u7684\u6b63\u9009\u62e9\u4e8b\u4ef6\u5f97\u4ee5\u5851\u9020\uff0c\u4ece\u800c\u751f\u6210\u80fd\u591f\u4e0e\u5bbf\u4e3bpMHC\u590d\u5408\u7269\u76f8\u4e92\u4f5c\u7528\u7684\u5916\u5468T\u7ec6\u80de\u5e93\u3002\u7136\u800c\uff0c\u4e3a\u4e86\u9650\u5236\u81ea\u8eab\u53cd\u5e94\u6027T\u7ec6\u80de\u7684\u53d1\u80b2\u548c\u6fc0\u6d3b\uff0c\u90a3\u4e9b\u8868\u73b0\u51fa\u9ad8\u4eb2\u548c\u529b\/\u4eb2\u548c\u5ea6\u7684TCR\u4e0e\u81ea\u8eabpMHC\u7ed3\u5408\u7684T\u7ec6\u80de\u4f1a\u901a\u8fc7\u4e2d\u67a2\u8010\u53d7\u673a\u5236\uff08\u5373\u8d1f\u9009\u62e9\uff09\u548c\/\u6216\u5916\u5468\u8010\u53d7\u673a\u5236\u88ab\u5220\u9664\u6216\u5931\u6d3b\u3002\u56e0\u6b64\uff0c\u73b0\u5728\u7684\u666e\u904d\u89c2\u70b9\u662f\uff0c\u9488\u5bf9\u81ea\u8eab\u548c\u975e\u81ea\u8eab\u6297\u539f\u7684\u5916\u5468T\u7ec6\u80de\u5e93\u5728TCR-pMHC\u7ed3\u5408\u4eb2\u548c\u529b\/\u4eb2\u548c\u5ea6\u65b9\u9762\u5b58\u5728\u5de8\u5927\u5dee\u5f02\uff08\u89c1Fig 40.2<\/span>\uff09\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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Fig. 40.2 <\/span>\u6574\u5408T\u7ec6\u80de\u529f\u80fd\u3001TCR\u4eb2\u548c\u529b\u53ca\u8c03\u8282\u7ec6\u80de\u53cd\u5e94\u7684\u6b63\/\u8d1f\u8c03\u8282\u56e0\u5b50\u7684\u5173\u7cfb\u6a21\u578b<\/span><\/p>\n

\u6211\u4eec\u8bc4\u4f30\u4e86\u4e00\u7ec4\u901a\u8fc7\u57fa\u56e0\u5de5\u7a0b\u6539\u9020\u7684CD8 T\u6dcb\u5df4\u7ec6\u80de\u7684\u529f\u80fd\u80fd\u529b\uff08y\u8f74\uff09\uff0c\u8fd9\u4e9b\u7ec6\u80de\u8868\u8fbe\u4e86\u5bf9HLA-A2\/NY-ESO-1\u8868\u4f4d\u5177\u6709\u9012\u589e\u4eb2\u548c\u529b\u7684\u6297\u80bf\u7624TCR\u3002\u7ed3\u679c\u8868\u660e\uff0cTCR-pMHC\u4eb2\u548c\u529b\u7684\u6700\u4f73\u7a97\u53e3\u4f4d\u4e8e\u81ea\u7136\u8303\u56f4\u7684\u4e0a\u9650\uff08KD\u4e3a5~1 \u03bcM\uff09\uff0c\u8fd9\u4e00\u8303\u56f4\u4e0e\u5927\u591a\u6570\u5916\u5468\u975e\u81ea\u8eab\/\u75c5\u6bd2\u7279\u5f02\u6027T\u7ec6\u80de\u7684\u4eb2\u548c\u529b\u76f8\u5bf9\u5e94\u3002\u6211\u4eec\u6700\u8fd1\u53d1\u73b0\uff0cT\u7ec6\u80de\u529f\u80fd\u7684\u6b63\u8c03\u8282\u56e0\u5b50\uff08\u5982CD28\u548cTNFR\u8f85\u56e0\u5b50\uff09\u5728\u5177\u6709\u6700\u4f73\u4eb2\u548c\u529b\u7684T\u7ec6\u80de\u4e2d\u5bcc\u96c6\uff0c\u800c\u6291\u5236\u6027\u53d7\u4f53PD-1\u53ca\u5176\u4e0b\u6e38\u7684SHP-1\u78f7\u9178\u9176\u5219\u53c2\u4e0e\u9650\u5236\u8d85\u751f\u7406\u4eb2\u548c\u529b\u7684TCR\u5de5\u7a0b\u5316CD8 T\u7ec6\u80de\u7684\u6fc0\u6d3b\u548c\u53cd\u5e94\u3002<\/p>\n

\u7814\u7a76\u8fd8\u8868\u660e\uff0c\u9776\u5411\u6bd2\u6027\u9075\u5faaCD8 T\u7ec6\u80de\u7684\u529f\u80fd\u548c\u6fc0\u6d3b\u7279\u5f81\uff0c\u800c\u968f\u7740TCR-pMHC\u4eb2\u548c\u529b\u7684\u589e\u52a0\uff0c\u7279\u522b\u662f\u5728\u8d85\u81ea\u7136\u4eb2\u548c\u529b\u8303\u56f4\u5185\uff0c\u4f1a\u51fa\u73b0\u8131\u9776\u53cd\u5e94\u548c\u6bd2\u6027\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u8bb8\u591a\u5728\u764c\u75c7\u60a3\u8005\u4e2d\u5e38\u89c1\u7684\u80bf\u7624\u76f8\u5173\u6297\u539f\uff0c\u5982\u8fc7\u8868\u8fbe\u6297\u539f\uff08\u4f8b\u5982Her2\/neu\u3001WT1\u6216\u7aef\u7c92\u9176\uff09\u3001\u5206\u5316\u6297\u539f\uff08\u5982Melan-A\/MART-1\u3001gp100\u6216\u916a\u6c28\u9178\u9176\uff09\u3001\u764c\u80da\u6297\u539f\uff08\u5982AFP\u6216CEA\uff09\u4ee5\u53ca\u80bf\u7624\u7279\u5f02\u6027\u6297\u539f\uff08\u5982NY-ESO-1\u6216MAGEs\uff09\uff0c\u5e76\u4e0d\u662f\u771f\u6b63\u610f\u4e49\u4e0a\u7684\u764c\u75c7\u7279\u5f02\u6027\u6297\u539f\uff0c\u56e0\u4e3a\u5b83\u4eec\u4e5f\u4f1a\u5728\u5065\u5eb7\u7ec4\u7ec7\u4e2d\u8868\u8fbe\u3002\u56e0\u6b64\uff0c\u9488\u5bf9\u81ea\u8eab\/\u80bf\u7624\u6297\u539f\u7684\u5929\u7136T\u7ec6\u80de\u5e93\uff0c\u901a\u5e38\u8868\u8fbe\u7684\u662f\u5177\u6709\u76f8\u5bf9\u4f4e\u4eb2\u548c\u529b\/\u4eb2\u548c\u5ea6\u7684TCR\uff0c\u800c\u9ad8\u4eb2\u548c\u529b\u7684T\u7ec6\u80de\u6781\u4e3a\u7f55\u89c1\uff0c\u56e0\u4e3a\u8fd9\u4e9b\u7ec6\u80de\u4f1a\u901a\u8fc7\u4e2d\u67a2\u8010\u53d7\u673a\u5236\u548c\/\u6216\u5916\u5468\u8010\u53d7\u673a\u5236\u88ab\u6d88\u9664\u3002<\/p>\n

Aleksic\u7b49\u4eba\u7684\u7814\u7a76\u8868\u660e\uff0c\u8fd9\u4e9bTCR-pMHC\u76f8\u4e92\u4f5c\u7528\u7684KD\u503c\u901a\u5e38\u5728200\u03bcM\u523010\u03bcM\u4e4b\u95f4\uff08\u5e73\u5747\u7ea6\u4e3a100\u03bcM\uff09\uff0c\u800c\u75c5\u6bd2\u7279\u5f02\u6027TCR\u7684KD\u76f8\u4e92\u4f5c\u7528\u8303\u56f4\u4e3a1\u03bcM\uff08\u5e73\u5747\u7ea6\u4e3a10\u03bcM\uff09\u3002\u5c3d\u7ba1\u5982\u6b64\uff0c\u8fd9\u4e9b\u8010\u53d7\u673a\u5236\u4f9d\u7136\u4fdd\u7559\u4e86\u5bf9\u81ea\u8eab\/\u80bf\u7624\u6297\u539f\u4ea7\u751f\u76f8\u5bf9\u8f83\u4f4e\u7684TCR-pMHC\u7ed3\u5408\u4eb2\u548c\u529b\/\u4eb2\u548c\u5ea6\u7684T\u7ec6\u80de\u3002\u56e0\u6b64\uff0c\u5c3d\u7ba1\u764c\u75c7\u60a3\u8005\u4f53\u5185\u53ef\u80fd\u5b58\u5728\u5927\u91cf\u7684\u81ea\u8eab\/\u80bf\u7624\u7279\u5f02\u6027T\u7ec6\u80de\uff0c\u4f46\u5b83\u4eec\u7684TCR\u4eb2\u548c\u529b\/\u4eb2\u548c\u5ea6\u5f80\u5f80\u8fc7\u4f4e\uff0c\u4e0d\u8db3\u4ee5\u4ecb\u5bfc\u6709\u6548\u7684\u6297\u80bf\u7624\u514d\u75ab\u53cd\u5e94\u3002<\/p>\n

\u56e0\u6b64\uff0c\u5728\u764c\u75c7\u514d\u75ab\u6cbb\u7597\u7684\u80cc\u666f\u4e0b\uff0c\u63d0\u5347\u80bf\u7624\u7279\u5f02\u6027T\u7ec6\u80de\u7684TCR-pMHC\u4eb2\u548c\u529b\u548c\/\u6216\u4eb2\u548c\u5ea6\u663e\u5f97\u5c24\u4e3a\u91cd\u8981\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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40.4 \u4f18\u5316TCR-pMHC\u4e0e\u764c\u7ec6\u80de\u7684\u7ed3\u5408\u4eb2\u548c\u529b\/\u4eb2\u548c\u5ea6<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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TCR\u5de5\u7a0b\u5316T\u7ec6\u80de\u7684\u8fc7\u7ee7\u6027\u8f6c\u79fb\u662f\u4e00\u79cd\u8fd1\u5e74\u6765\u53d1\u5c55\u7684\u514d\u75ab\u6cbb\u7597\u624b\u6bb5\uff0c\u65e8\u5728\u589e\u5f3a\u9488\u5bf9\u514d\u75ab\u539f\u6027\u8f83\u5dee\u80bf\u7624\u7684\u514d\u75ab\u53cd\u5e94\u3002\u8be5\u7b56\u7565\u4f9d\u8d56\u4e8e\u4f18\u5316TCR\u5e8f\u5217\uff0c\u4ee5\u63d0\u9ad8\u5176\u4e0e\u540c\u6e90\u80bf\u7624\u6297\u539f\u7684\u4eb2\u548c\u529b\/\u4eb2\u548c\u5ea6\uff0c\u5e76\u5c06\u8fd9\u4e9b\u5de5\u7a0b\u5316T\u7ec6\u80de\u901a\u8fc7\u8fc7\u7ee7\u6027\u7ec6\u80de\u8f6c\u79fb\u56de\u8f93\u7ed9\u60a3\u8005\u3002\u5b9e\u9645\u4e0a\uff0c\u5de5\u7a0b\u5316T\u7ec6\u80de\u7684\u8fc7\u7ee7\u8f6c\u79fb\u663e\u8457\u589e\u5f3a\u4e86\u80bf\u7624\u6297\u539f\u53cd\u5e94\u6027CD8 T\u7ec6\u80de\u7684\u529f\u80fd\u548c\u4fdd\u62a4\u80fd\u529b\u3002<\/p>\n

\u8fd1\u5e74\u6765\uff0c\u6211\u4eec\u901a\u8fc7\u57fa\u4e8e\u7ed3\u6784\u7684\u5408\u7406\u8bbe\u8ba1\uff0c\u5f00\u53d1\u4e86\u4e00\u7ec4\u72ec\u7279\u7684\u4eba\u7c7bCD8 T\u7ec6\u80de\uff0c\u8fd9\u4e9bT\u7ec6\u80de\u7ecf\u8fc7\u5de5\u7a0b\u5316\u5904\u7406\uff0c\u8868\u8fbe\u9010\u6e10\u589e\u52a0\u4eb2\u548c\u529b\u7684TCR\uff0c\u9488\u5bf9HLA-A2\u80cc\u666f\u4e0b\u5448\u73b0\u7684\u80bf\u7624\u6297\u539fNY-ESO-1\u3002\u7814\u7a76\u7ed3\u679c\u8868\u660e\uff0c\u8868\u8fbe\u4e0a\u9650\u81ea\u7136\u8303\u56f4\u5185\u4eb2\u548c\u529b\uff08KD\u4e3a5\u52301\u03bcM\uff09\u7684TCR\u7684T\u7ec6\u80de\uff0c\u4e0e\u8868\u8fbe\u4e2d\u7b49\u4eb2\u548c\u529b\u7684\u91ce\u751f\u578bTCR\uff08KD\u4e3a21.4\u03bcM\uff09\u6216\u6781\u4f4e\u4eb2\u548c\u529bTCR\uff08KD>100\u03bcM\uff09\u7684T\u7ec6\u80de\u76f8\u6bd4\uff0c\u5c55\u73b0\u51fa\u66f4\u5f3a\u7684\u751f\u7269\u5b66\u53cd\u5e94\u6027\uff08\u89c1Fig 40.2<\/span>\uff09\u3002<\/p>\n

\u9996\u5148\uff0c\u6211\u4eec\u89c2\u5bdf\u5230\uff0c\u5728\u8868\u8fbe\u9ad8\u4eb2\u548c\u529bTCR\u7684T\u7ec6\u80de\u4e2d\uff0c\u6291\u5236\u6027\u53d7\u4f53PD-1\u7684\u8868\u8fbe\u66f4\u4e3a\u663e\u8457\uff0c\u4e14\u5728\u963b\u65adPD-1\u914d\u4f53PD-L1\u540e\uff0c\u8fd9\u4e9bT\u7ec6\u80de\u7684\u529f\u80fd\u5f97\u4ee5\u6062\u590d\u3002\u5176\u6b21\uff0c\u968f\u7740TCR\u4eb2\u548c\u529b\u7684\u589e\u52a0\uff0c\u6211\u4eec\u8fd8\u53d1\u73b0SHP-1\u78f7\u9178\u9176\u5728CD8 T\u7ec6\u80de\u4e2d\u9010\u6e10\u4e0a\u8c03\u3002\u56e0\u6b64\uff0c\u836f\u7406\u5b66\u6291\u5236SHP-1\u80fd\u591f\u8fdb\u4e00\u6b65\u63d0\u9ad8\u8fd9\u4e9b\u5de5\u7a0b\u5316T\u7ec6\u80de\u7684\u529f\u80fd\uff0c\u5177\u4f53\u6548\u679c\u53d6\u51b3\u4e8e\u5b83\u4eec\u7684TCR\u7ed3\u5408\u4eb2\u548c\u529b\u3002<\/p>\n

\u6211\u4eec\u7684\u89c2\u5bdf\u7ed3\u679c\u4e0e\u5176\u4ed6\u7814\u7a76\uff08\u57fa\u4e8e\u5c0f\u9f20\u548c\u4eba\u7c7b\u6a21\u578b\uff09\u975e\u5e38\u4e00\u81f4\uff0c\u5e76\u63d0\u4f9b\u4e86\u6709\u529b\u7684\u8bc1\u636e\uff0c\u8868\u660eT\u7ec6\u80de\u7684\u6fc0\u6d3b\u4e0e\u4fe1\u53f7\u4f20\u5bfc\u5728TCR-pMHC\u76f8\u4e92\u4f5c\u7528\u8fbe\u5230\u67d0\u4e00\u4eb2\u548c\u529b\u9608\u503c\u65f6\u589e\u5f3a\uff0c\u4f46\u5982\u679c\u8d85\u8fc7\u6b64\u9608\u503c\uff0cT\u7ec6\u80de\u7684\u529f\u80fd\u53ef\u80fd\u4f1a\u53d7\u5230\u6291\u5236\uff0c\u65e0\u6cd5\u7ee7\u7eed\u53d1\u6325\u6709\u6548\u4f5c\u7528\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u4e00\u4e9b\u4e34\u5e8a\u8bd5\u9a8c\u5df2\u7ecf\u8bc1\u5b9e\u4e86TCR-pMHC\u7ed3\u5408\u53c2\u6570\u5bf9\u6cbb\u7597\u6548\u679c\u7684\u91cd\u8981\u6027\uff08\u89c1Table 40.1<\/span>\uff09\u3002\u65e9\u671f\u7814\u7a76\u8868\u660e\uff0c\u4e0e\u4f4e\u4eb2\u548c\u529b\u7684T\u7ec6\u80de\u76f8\u6bd4\uff0c\u9ad8\u4eb2\u548c\u529b\u7684\u80bf\u7624\u7279\u5f02\u6027T\u7ec6\u80de\u53cd\u5e94\u901a\u5e38\u4e0e\u81ea\u8eab\u514d\u75ab\u53cd\u5e94\u76f8\u5173\u3002\u5728\u4e00\u9879\u9488\u5bf9\u9ed1\u8272\u7d20\u7624\u7684\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\uff0c\u60a3\u8005\u63a5\u53d7\u4e86\u4eb2\u548c\u6027\u4f18\u5316TCR\u8f6c\u5bfc\u7684\u81ea\u4f53\u8840\u6db2\u5355\u6838\u7ec6\u80de\u6cbb\u7597\uff0c\u9776\u5411\u5206\u5316\u80bf\u7624\u6297\u539fMelan-A\/MART-1\uff08\u89c1Table 40.1<\/span>\uff09\u3002\u4e0e\u5929\u7136\u7684\u4f4eTCR\u4eb2\u548c\u529b\uff08DMF4\uff09\u76f8\u6bd4\uff0c\u5177\u6709\u66f4\u9ad8\u7ed3\u5408\u4eb2\u548c\u529b\u7684DMF5 TCR\u5728\u4e34\u5e8a\u4e0a\u8868\u73b0\u51fa\u66f4\u597d\u7684\u7597\u6548\u3002<\/p>\n

\u7136\u800c\uff0c\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u8868\u8fbe\u66f4\u591a\u81ea\u8eab\/\u80bf\u7624\u7279\u5f02\u6027TCR\u7684T\u7ec6\u80de\u4e5f\u53ef\u80fd\u4f1a\u9776\u5411\u6b63\u5e38\u7ec4\u7ec7\u4e2d\u8868\u8fbe\u540c\u6e90\u6297\u539f\u7684\u7ec6\u80de\uff08\u5982\u76ae\u80a4\u3001\u773c\u775b\u548c\u8033\u6735\u4e2d\u7684\u9ed1\u8272\u7d20\u7ec6\u80de\uff0c\u5b83\u4eec\u8868\u8fbeMelan-A\u548cgp100\uff09\uff0c\u4ece\u800c\u5728\u60a3\u8005\u4f53\u5185\u5f15\u53d1\u6709\u5bb3\u7684\u7ec6\u80de\u6bd2\u6027\u514d\u75ab\u53cd\u5e94\u3002\u7c7b\u4f3c\u7684\u9776\u5411\u53cd\u5e94\u4e5f\u5728\u4f7f\u7528\u9488\u5bf9\u764c\u80da\u6297\u539f\uff08CEA\uff09\u7684TCR\u6cbb\u7597\u96be\u6cbb\u6027\u8f6c\u79fb\u6027\u7ed3\u80a0\u764c\u60a3\u8005\u4e2d\u89c2\u5bdf\u5230\uff0c\u867d\u7136\u8fd9\u4e9b\u60a3\u8005\u7684\u8840\u6e05CEA\u6c34\u5e73\u6709\u6240\u4e0b\u964d\uff0c\u4f46\u4e5f\u4f34\u968f\u51fa\u73b0\u4e86\u4e25\u91cd\u7684\u77ed\u6682\u6027\u708e\u6027\u7ed3\u80a0\u708e\u3002<\/p>\n

\u6709\u8da3\u7684\u662f\uff0c\u57fa\u4e8eA*0201\/NY-ESO-1\u764c\u777e\u4e38\u6297\u539f\u6a21\u578b\u7684\u7814\u7a76\u8868\u660e\uff0c\u57fa\u56e0\u4f18\u5316T\u7ec6\u80de\u80fd\u591f\u4ea7\u751f\u663e\u8457\u7684\u529f\u80fd\u53cd\u5e94\uff0c\u5bfc\u81f4\u5ba2\u89c2\u7684\u4e34\u5e8a\u53cd\u5e94\uff0c\u4e14\u672a\u89c2\u5bdf\u5230\u660e\u663e\u7684\u4f53\u5185\u4ea4\u53c9\u53cd\u5e94\u6027\u6216\u4e25\u91cd\u4e0d\u826f\u4e8b\u4ef6\u3002\u8fd9\u4e9b\u770b\u4f3c\u77db\u76fe\u7684\u7ed3\u679c\u53ef\u4ee5\u901a\u8fc7\u6297\u539f\u5206\u5e03\u7684\u5dee\u5f02\u6765\u89e3\u91ca\uff1aNY-ESO-1\u6297\u539f\u4ec5\u5728\u777e\u4e38\u7ec6\u80de\u4e2d\u8868\u8fbe\uff0c\u800cMelan-A\u6216CEA\u6297\u539f\u5e7f\u6cdb\u5b58\u5728\u4e8e\u6b63\u5e38\u9ed1\u8272\u7d20\u7ec6\u80de\u6216\u80c3\u80a0\u9053\u4e0a\u76ae\u7ec6\u80de\u4e2d\u3002\u56e0\u6b64\uff0c\u5728\u8fc7\u7ee7\u7ec6\u80de\u8f6c\u79fb\u4e2d\u4f18\u5316T\u7ec6\u80de\u7684\u6297\u539f\u7279\u5f02\u6027\u9009\u62e9\u5bf9\u4e8e\u63d0\u5347\u7597\u6548\u3001\u907f\u514d\u526f\u4f5c\u7528\u81f3\u5173\u91cd\u8981\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
<\/section>\n<\/section>\n
\n
\n
\n


<\/p>\n<\/section>\n<\/section>\n

\n
\n

Table 40.1<\/span> <\/span>\u4f7f\u7528TCR\u7ed3\u5408\u4eb2\u548c\u529b\/\u4eb2\u5408\u529b\u4f18\u5316\u7684T\u7ec6\u80de\u8fdb\u884c\u7684\u4e34\u5e8a\u8bd5\u9a8c<\/span><\/p>\n

a. \u6839\u636e\u5b9e\u4f53\u7624\u7597\u6548\u8bc4\u4ef7\u6807\u51c6\uff08RECIST\uff09\u6216\u9aa8\u9ad3\u7624\u8bc4\u4f30\u7684\u56fd\u9645\u7edf\u4e00\u7597\u6548\u6807\u51c6\u5f97\u51fa\u7684\u5ba2\u89c2\u7f13\u89e3\uff08OR\uff09\uff0c\u5305\u62ec\u90e8\u5206\u6216\u5b8c\u5168\u7f13\u89e3\u3002<\/p>\n

b. \u5e94\u7b54\u60a3\u8005\u6570\/\u603b\u60a3\u8005\u6570\uff08\u5e94\u7b54\u767e\u5206\u6bd4\uff09\u3002<\/p>\n

c. \u6839\u636e\u5b9e\u4f53\u7624\u7597\u6548\u8bc4\u4ef7\u6807\u51c6\uff08RECIST\uff09\u6216\u56fd\u9645\u9aa8\u9ad3\u7624\u5de5\u4f5c\u7ec4\uff08IMWG\uff09\u7684\u6807\u51c6\uff0cCR\u8868\u793a\u5b8c\u5168\u7f13\u89e3\u6216\u63a5\u8fd1\u5b8c\u5168\u7f13\u89e3\u3002<\/p>\n

d. NA\uff1a\u4e0d\u9002\u7528\u3002<\/p>\n

e. \u4e0e\u8f93\u5165T\u7ec6\u80de\u7684\u5f00\/\u8131\u9776\u6bd2\u6027\u65e0\u5173\u7684\u4e0d\u826f\u4e8b\u4ef6\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u53e6\u4e00\u4e2a\u91cd\u8981\u7684\u53c2\u6570\u662f\u81ea\u80bd\u4ea4\u53c9\u53cd\u5e94\u6027\u589e\u52a0\u7684\u98ce\u9669\uff0c\u8fd9\u53ef\u80fd\u5bfc\u81f4\u8131\u9776\u6bd2\u6027\u3002\u5b9e\u9a8c\u6a21\u578b\u5df2\u7ecf\u8bc1\u660e\uff0cTCR\u4e0epMHC\u590d\u5408\u7269\u7ed3\u5408\u7684T\u7ec6\u80de\u5728\u6d3b\u6027\u6781\u9ad8\u7684\u60c5\u51b5\u4e0b\uff0c\u53ef\u80fd\u4f1a\u5931\u53bb\u6297\u539f\u7279\u5f02\u6027\uff0c\u5e76\u4ea7\u751f\u4ea4\u53c9\u53cd\u5e94\u3002\u540c\u6837\uff0c\u8fd1\u671f\u7684\u4e34\u5e8a\u8bd5\u9a8c\u663e\u793a\uff0c\u4eb2\u548c\u529b\u589e\u5f3a\u7684TCR\u5982\u679c\u8d85\u8fc7\u67d0\u4e2a\u9608\u503c\uff0c\u53ef\u80fd\u5bfc\u81f4\u60a3\u8005\u51fa\u73b0\u4e25\u91cd\u7684\u8131\u9776\u526f\u4f5c\u7528\u3002<\/p>\n

\u4f8b\u5982\uff0c\u63a5\u53d7TCR\u6cbb\u7597\u7684\u60a3\u8005\u5bf9\u777e\u4e38\u764cHLA-A1\/MAGE-A3\u80bf\u7624\u6297\u539f\u7684\u589e\u5f3a\u4eb2\u548c\u529b\uff0c\u5bfc\u81f4T\u7ec6\u80de\u5bf9\u5fc3\u808c\u7279\u5f02\u6027\u86cb\u767dTitin\u4ea7\u751f\u8131\u9776\u8bc6\u522b\uff0c\u8fdb\u800c\u5f15\u53d1\u4e25\u91cd\u4e0d\u826f\u53cd\u5e94\uff08SAE\uff09\u548c\u5bf9\u5fc3\u810f\u7ec4\u7ec7\u7684\u81f4\u547d\u6bd2\u6027\u3002\u6b64\u5916\uff0c\u4e24\u540d\u8f93\u6ce8\u4e86\u81ea\u4f53\u6297HLA-A2\/MAGE-A3 TCR\u5de5\u7a0bT\u7ec6\u80de\u7684\u60a3\u8005\u51fa\u73b0\u4e86\u795e\u7ecf\u6bd2\u6027\uff0c\u4f34\u968f\u7cbe\u795e\u53d8\u5316\uff0c\u6700\u7ec8\u5bfc\u81f4\u6b7b\u4ea1\u3002\u8fd9\u88ab\u8ba4\u4e3a\u662f\u7531\u4e8eTCR\u5bf9\u4eba\u8111\u4e2d\u8868\u8fbe\u7684MAGE-A12\u81ea\u8eab\u6297\u539f\u7684\u4ea4\u53c9\u53cd\u5e94\u6240\u81f4\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u8fd9\u4e9b\u7ed3\u679c\u4e0d\u4ec5\u8bc1\u660e\u4e86\u4eb2\u548c\u6539\u826fTCR\u5728\u4f53\u5185\u5177\u6709\u5f3a\u5927\u7684\u6297\u80bf\u7624\u6548\u5e94\uff0c\u4e5f\u5f3a\u8c03\u4e86\u5176\u6f5c\u5728\u7684\u5b89\u5168\u6027\u95ee\u9898\uff08\u89c1Table 40.1<\/span>\uff09\u3002\u56e0\u6b64\uff0c\u6211\u4eec\u548c\u5176\u4ed6\u7814\u7a76\u8005\u63d0\u51fa\uff0c\u6539\u826f\u7684\u81ea\u8eab\u7279\u5f02\u6027TCR\u7684\u8bbe\u8ba1\u4e0d\u5e94\u8d85\u8fc7\u5929\u7136TCR\u4eb2\u548c\u529b\u7684\u8303\u56f4\uff0c\u4ee5\u786e\u4fdd\u6700\u4f73T\u7ec6\u80de\u529f\u80fd\uff0c\u5e76\u907f\u514d\u4e0d\u53ef\u9884\u6d4b\u7684\u4ea4\u53c9\u53cd\u5e94\u6027\u98ce\u9669\uff08\u89c1Fig 40.2<\/span>\uff09\u3002\u4e3a\u6b64\uff0c\u66f4\u597d\u7684\u4e34\u5e8a\u524d\u8bc4\u4f30\u662f\u8feb\u5207\u9700\u8981\u7684\uff0c\u4ee5\u8bc4\u4f30\u5de5\u7a0b\u5316TCR\u7684\u7cbe\u786e\u6297\u539f\u7279\u5f02\u6027\uff0c\u5e76\u786e\u5b9a\u4e0e\u4eb2\u548c\u529b\u6539\u826fTCR\u8fc7\u7ee7\u7ec6\u80de\u8f6c\u79fb\u6700\u5408\u9002\u7684\u80bf\u7624\u6297\u539f\u3002<\/p>\n

\u91cd\u8981\u7684\u662f\uff0c\u4f18\u5316TCR\u4eb2\u548c\u529b\u7684\u8fc7\u7a0b\u4e2d\uff0c\u5fc5\u987b\u8bc4\u4f30T\u7ec6\u80de\u7684\u6700\u4f73\u53cd\u5e94\u6027\uff0c\u5e76\u786e\u4fdd\u4e0d\u4f1a\u56e0\u4e3a\u81ea\u8eab\u53cd\u5e94\u6027\u800c\u5f15\u53d1\u9776\u5411\u548c\u8131\u9776\u526f\u4f5c\u7528\uff0c\u4ece\u800c\u4fdd\u8bc1TCR\u5de5\u7a0bT\u7ec6\u80de\u5728\u672a\u6765\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u7684\u5b89\u5168\u6027\u3002\u5728\u8fd9\u65b9\u9762\uff0c\u9700\u8981\u5f00\u53d1\u65b0\u7684\u7b56\u7565\uff0c\u4ee5\u8bc6\u522b\u548c\u9009\u62e9\u90a3\u4e9b\u81ea\u7136\u53d1\u751f\u4f46\u7f55\u89c1\u7684\u81ea\u8eab\/\u80bf\u7624\u6297\u539f\u7279\u5f02\u6027T\u6dcb\u5df4\u7ec6\u80de\u3002\u8fd9\u4e9b\u7ec6\u80de\u5728\u751f\u7406TCR\u4eb2\u548c\u529b\u8303\u56f4\u5185\u8868\u73b0\u51fa\u6700\u9ad8\u7684TCR\u7ed3\u5408\u6d3b\u6027\u548c\u529f\u80fd\uff0c\u5c06\u5728\u540e\u7eed\u8fdb\u4e00\u6b65\u63cf\u8ff0\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u672c\u6587\u7531Oncolab\u5fae\u4fe1\u516c\u4f17\u53f7\u7ffb\u8bd1\u6574\u7406\u81eaOncoimmunology: A Practical Guide for Cancer Immunotherapy\uff0c\u4ec5\u7528\u4e8e\u5b66\u4e60\u4ea4\u6d41\u4f7f\u7528\uff0c\u5982\u9700\u8d2d\u4e70\u539f\u7248\u4e66\u7c4d\u53ef\u70b9\u51fb\u9605\u8bfb\u539f\u6587\u8d2d\u4e70\u3002<\/span>
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\u2014 THE  END \u2014<\/span><\/p>\n


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\u6765\u6e90 | Oncoimmunology: A Practical Guide <\/span><\/p>\n

for Cancer Immunotherapy<\/span><\/p>\n

\u521d\u7a3f\u7ffb\u8bd1 | \u4f55\u4e3d\u5a1c<\/span><\/p>\n

\u56fe\u6587\u6392\u7248 | \u8d75\u6829 \u9ea6\u601d\u6dcb<\/span><\/span><\/p>\n

\u5ba1\u6838\u4fee\u6539 | \u738b\u5764<\/span><\/p>\n

\uff08\u8f6c\u8f7d\u8bf7\u4fdd\u7559\u6b64\u90e8\u5206\u5185\u5bb9\uff09<\/span><\/strong><\/p>\n


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\u53ef\u4ee5\u67e5\u8be22024\u5e74\u6700\u65b0SCI\u671f\u520a\u5f71\u54cd\u56e0\u5b50\u53ca\u5206\u533a\u5566\uff01<\/span><\/a>
\u514d\u75ab\u5b66\u62fe\u9057\u7cfb\u5217<\/span><\/a><\/p>\n

\u80bf\u7624\u514d\u75ab\u5b66\u7cfb\u5217<\/span><\/a><\/p>\n

\u795e\u7ecf\u79d1\u5b66\u539f\u7406\u7cfb\u5217<\/span><\/a><\/p>\n

ACIR\u6587\u732e\u901f\u9012<\/span><\/a><\/p>\n

SCI\u8bba\u6587\u4f5c\u56fe<\/span><\/a><\/p>\n

SCI\u8bba\u6587\u5199\u4f5c\u53ca\u6295\u7a3f<\/span><\/a><\/p>\n

\u751f\u4fe1\u5165\u95e8\u5b66\u4e60\u7b14\u8bb0<\/span><\/a><\/p>\n

R\u8bed\u8a00\u57fa\u7840\u4e0e\u5355\u7ec6\u80de\u5206\u6790\u5b9e\u6218\u89c6\u9891\u8bfe\u7a0b<\/span><\/a><\/p>\n

\u751f\u7269\u5b66\u5b9e\u9a8c\u6280\u672f\u53ca\u5e38\u7528\u8f6f\u4ef6<\/span><\/a><\/p>\n

\u5e38\u7528\u5b9e\u9a8c<\/span>\u4eea\u5668\u7b80\u4ecb\u53ca\u64cd\u4f5c\u89c6\u9891<\/span><\/a><\/span><\/p>\n

\u5e38\u7528\u7535\u8111\u8f6f\u4ef6\u4f7f\u7528\u6559\u7a0b<\/span><\/a><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u70b9\u4eae\u8d5e\u4e0e\u5728\u770b <\/span><\/p>\n

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\u672c\u7bc7\u6587\u7ae0\u6765\u6e90\u4e8e\u5fae\u4fe1\u516c\u4f17\u53f7:OncoLab<\/p>\n<\/blockquote>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

40.1 \u6cbb\u7597\u6076\u6027\u75be\u75c5\u7684T\u7ec6\u80de\u7597\u6cd5 \u7ec6\u80de\u6bd2\u6027CD8 T\u7ec6\u80de\u4e0d\u4ec5\u5728\u62b5\u5fa1\u591a\u79cd\u4f20\u67d3\u75c5\u4e2d\u53d1\u6325\u5173\u952e\u4f5c\u7528\uff0c\u8fd1\u5e74\u6765\u7684\u7814\u7a76\u8868\u660e\uff0c\u5b83\u4eec\u540c\u6837\u53ef\u4ee5\u6709\u6548\u6e05\u9664\u80bf\u7624\u7ec6\u80de\u3002\u764c\u75c7\u514d\u75ab\u53cd\u5e94\u7684\u6838\u5fc3\u5728\u4e8e\u8868\u8fbe\u80bf\u7624\u7279\u5f02\u6027T…<\/p>\n","protected":false},"author":1,"featured_media":5726,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[59],"tags":[],"_links":{"self":[{"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/posts\/5730"}],"collection":[{"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/comments?post=5730"}],"version-history":[{"count":0,"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/posts\/5730\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/media\/5726"}],"wp:attachment":[{"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/media?parent=5730"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/categories?post=5730"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/tags?post=5730"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}