{"id":5734,"date":"2024-09-22T11:02:20","date_gmt":"2024-09-22T03:02:20","guid":{"rendered":"http:\/\/dh.oncolab.cn\/index.php\/2024\/09\/22\/%e8%82%bf%e7%98%a4%e5%85%8d%e7%96%ab%e5%ad%a6-%e7%ac%ac40%e7%ab%a0-%e8%af%84%e4%bc%b0t%e7%bb%86%e8%83%9e%e5%8f%97%e4%bd%93%e7%9a%84%e4%ba%b2%e5%92%8c%e5%8a%9b%e5%8f%8a%e9%92%88%e5%af%b9%e8%82%bf-2\/"},"modified":"2024-09-22T11:02:20","modified_gmt":"2024-09-22T03:02:20","slug":"%e8%82%bf%e7%98%a4%e5%85%8d%e7%96%ab%e5%ad%a6-%e7%ac%ac40%e7%ab%a0-%e8%af%84%e4%bc%b0t%e7%bb%86%e8%83%9e%e5%8f%97%e4%bd%93%e7%9a%84%e4%ba%b2%e5%92%8c%e5%8a%9b%e5%8f%8a%e9%92%88%e5%af%b9%e8%82%bf-2","status":"publish","type":"post","link":"http:\/\/dh.oncolab.cn\/index.php\/2024\/09\/22\/%e8%82%bf%e7%98%a4%e5%85%8d%e7%96%ab%e5%ad%a6-%e7%ac%ac40%e7%ab%a0-%e8%af%84%e4%bc%b0t%e7%bb%86%e8%83%9e%e5%8f%97%e4%bd%93%e7%9a%84%e4%ba%b2%e5%92%8c%e5%8a%9b%e5%8f%8a%e9%92%88%e5%af%b9%e8%82%bf-2\/","title":{"rendered":"\u80bf\u7624\u514d\u75ab\u5b66-\u7b2c40\u7ae0 \u8bc4\u4f30T\u7ec6\u80de\u53d7\u4f53\u7684\u4eb2\u548c\u529b\u53ca\u9488\u5bf9\u80bf\u7624\u6297\u539f\u7684\u4eb2\u548c\u5ea6\uff08\u4e0b\uff09"},"content":{"rendered":"
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\u4e0a\u671f\u5185\u5bb9\uff1a\u80bf\u7624\u514d\u75ab\u5b66-\u7b2c40\u7ae0 \u8bc4\u4f30T\u7ec6\u80de\u53d7\u4f53\u7684\u4eb2\u548c\u529b\u53ca\u9488\u5bf9\u80bf\u7624\u6297\u539f\u7684\u4eb2\u548c\u5ea6\uff08\u4e0a\uff09<\/span><\/a><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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40.5 TCR-pMHC\u7684\u7ed3\u5408\u53ca\u52a8\u529b\u5b66\u6d4b\u91cf<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u4e3a\u4e86\u8be6\u7ec6\u8868\u5f81TCR-pMHC\u7ed3\u5408\u7684\u4eb2\u548c\u529b\/\u4eb2\u5408\u529b\uff0c\u5e76\u89e3\u6790\u8fd9\u79cd\u5206\u5b50\u76f8\u4e92\u4f5c\u7528\u7684\u7ed3\u5408\u901f\u7387\u548c\u89e3\u79bb\u901f\u7387\u7684\u52a8\u529b\u5b66\u8d21\u732e\uff0c\u5df2\u7ecf\u91c7\u7528\u4e86\u51e0\u79cd\u6280\u672f\u3002\u5728\u672c\u8282\u4e2d\uff0c\u6211\u4eec\u5c06\u603b\u7ed3\u76ee\u524d\u4f7f\u7528\u7684\u4e0d\u540c\u65b9\u6cd5\uff0c\u5e76\u91cd\u70b9\u4ecb\u7ecd\u5b83\u4eec\u5404\u81ea\u7684\u4f18\u7f3a\u70b9\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u65e9\u671f\u7684\u6676\u4f53\u5b66\u5206\u6790\u8868\u660e\uff0cTCR-pMHC\u7ed3\u6784\u4e0eT\u7ec6\u80de\u529f\u80fd\u4e4b\u95f4\u7f3a\u4e4f\u663e\u8457\u76f8\u5173\u6027\uff0c\u8fd9\u63d0\u793aT\u7ec6\u80de\u7684\u6fc0\u6d3b\u4f9d\u8d56\u4e8e\u52a8\u6001\u8fc7\u7a0b\u3002\u56e0\u6b64\uff0c\u4e3b\u8981\u4f7f\u7528\u8868\u9762\u7b49\u79bb\u5b50\u4f53\u5171\u632f\uff08SPR\uff09\u751f\u7269\u4f20\u611f\u5668\u5bf9TCR-pMHC\u76f8\u4e92\u4f5c\u7528\u7684\u52a8\u529b\u5b66\u548c\u7ed3\u5408\u53c2\u6570\u8fdb\u884c\u5b9a\u91cf\u6d4b\u91cf\u3002\u8fd9\u79cd\u6280\u672f\u5141\u8bb8\u540c\u65f6\u68c0\u6d4b\u7ed3\u5408\u901f\u7387\u548c\u89e3\u79bb\u901f\u7387\uff0c\u4ee5\u53ca\u5206\u5b50\u4eb2\u548c\u5ea6\uff081\/KD\uff09\uff0c\u4ece\u800c\u63d0\u4f9b\u6240\u8c13\u7684\u201c3D\u4eb2\u548c\u5ea6\u201d\u53c2\u6570\u3002\u5177\u4f53\u6765\u8bf4\uff0cSPR\u6d4b\u91cf\u4e2d\u4e00\u4e2a\u5206\u5b50\u5728\u6eb6\u6db2\u4e2d\u6d41\u8fc7\u4f20\u611f\u5668\u82af\u7247\uff0c\u800c\u53e6\u4e00\u4e2a\u6f5c\u5728\u7684\u76f8\u4e92\u4f5c\u7528\u76ee\u6807\u5219\u56fa\u5b9a\u5728\u82af\u7247\u4e0a\uff08\u89c1Fig 40.1b<\/span>\uff09\u3002<\/p>\n

\u4eceSPR\u7814\u7a76\u6536\u96c6\u7684\u6570\u636e\u8868\u660e\uff0c\u4e0e\u5176\u4ed6\u751f\u7269\u5206\u5b50\u76f8\u4e92\u4f5c\u7528\u76f8\u6bd4\uff0c\u5929\u7136\u4eba\u7c7bTCR-pMHC\u76f8\u4e92\u4f5c\u7528\u7684\u4eb2\u548c\u529b\u8f83\u5f31\uff08KD\u8303\u56f4\u4e3a500 \u03bcM\u81f31 \u03bcM\uff09\uff0c\u8868\u73b0\u4e3a\u89e3\u79bb\u901f\u7387\u5feb\u3001\u7ed3\u5408\u901f\u7387\u6162\u3002\u7136\u800c\uff0cSPR\u6280\u672f\u7684\u4e00\u4e2a\u56fa\u6709\u7f3a\u70b9\u662f\uff0c\u5b83\u9700\u8981\u8017\u65f6\u8d39\u529b\u5730\u751f\u4ea7\u53ef\u6eb6\u6027TCR\u548cpMHC\u5206\u5b50\uff0c\u5e76\u4e14\u5ffd\u7565\u4e86CD8\u5171\u53d7\u4f53\u53ca\u5176\u4ed6\u819c\u5206\u5b50\u5bf9TCR-pMHC\u76f8\u4e92\u4f5c\u7528\u7684\u7ed3\u5408\u8d21\u732e\u3002<\/p>\n

\u6700\u8fd1\uff0c\u65b0\u4e00\u4ee3\u6280\u672f\u5982\u8026\u5408\u663e\u5fae\u955c\u7684SPR\u4eb2\u548c\u6d4b\u91cf\uff0c\u4ee5\u53ca\u77f3\u82f1\u6676\u4f53\u5fae\u5e73\u8861\uff08QCM\uff09\u751f\u7269\u4f20\u611f\u5668\uff0c\u5df2\u7ecf\u88ab\u8bbe\u8ba1\u7528\u4e8e\u76f4\u63a5\u5728\u6d3b\u7ec6\u80de\u8868\u9762\u68c0\u6d4b\u819c\u86cb\u767d\u4e4b\u95f4\u7684\u5b9e\u65f6\u76f8\u4e92\u4f5c\u7528\u548c\u52a8\u529b\u5b66\u3002\u8fd9\u4e9b\u65b0\u6280\u672f\u6709\u671b\u7528\u4e8e\u7814\u7a76\u6d3b\u4f53\u81ea\u8eab\/\u80bf\u7624\u6297\u539f\u7279\u5f02\u6027T\u7ec6\u80de\u8868\u9762\u4f4e\u4eb2\u548c\u529b\u7684TCR-pMHC\u76f8\u4e92\u4f5c\u7528\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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Fig. 40.1<\/span><\/span><\/span>\u5b9a\u4e49\u548c\u8bc4\u4f30T\u7ec6\u80de\u529f\u80fd\u4eb2\u548c\u529b\u4e0eTCR-pMHC\u7ed3\u5408\u4eb2\u548c\u529b\/\u4eb2\u5408\u529b<\/span><\/p>\n

(a) T\u7ec6\u80de\u529f\u80fd\u4eb2\u548c\u529b\u53cd\u6620T\u7ec6\u80de\u5bf9\u6297\u539f\u7279\u5f02\u6027\u523a\u6fc0\u7684\u53cd\u5e94\u6027\uff0c\u8bc4\u4f30\u65b9\u5f0f\u4e3aT\u7ec6\u80de\u5728\u66b4\u9732\u4e8e\u6ef4\u5b9a\u5242\u91cf\u6297\u539f\u80bd\u65f6\u7684\u529f\u80fd\u53cd\u5e94\uff08\u5982\u7ec6\u80de\u6bd2\u6027\u6d3b\u6027\u3001IFN-\u03b3\u4ea7\u751f\u6216\u589e\u6b96\uff09\u3002EC50\u5b9a\u4e49\u4e3a\u4ea7\u751f\u534a\u6700\u5927\u53cd\u5e94\u7684\u80bd\u6d53\u5ea6\u3002<\/p>\n

(b) TCR-pMHC\u7ed3\u5408\u4eb2\u548c\u529b\u548c\u4eb2\u5408\u529b\u63cf\u8ff0\u7684\u662fTCR\u4e0e\u5176\u6297\u539f\u4e4b\u95f4\u5355\u4f53\/\u591a\u805a\u4f53\u7ed3\u5408\u76f8\u4e92\u4f5c\u7528\u5f3a\u5ea6\u7684\u751f\u7269\u7269\u7406\u8bfb\u6570\uff0c\u901a\u5e38\u4f7f\u7528SPR\u548cpMHC\u591a\u4ef7\u7ed3\u5408\u8bd5\u5242\u6765\u6d4b\u91cf\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u9664\u4e86SPR\u6280\u672f\u4e4b\u5916\uff0c\u8fd1\u5e74\u6765\u8fd8\u5f00\u53d1\u4e86\u5176\u4ed6\u57fa\u4e8e\u673a\u68b0\u6216\u8367\u5149\u5206\u6790\u7684\u6280\u672f\uff0c\u8fd9\u4e9b\u6280\u672f\u53ef\u4ee5\u76f4\u63a5\u5728\u6d3bT\u7ec6\u80de\u4e0e\u66ff\u4ee3\u6297\u539f\u5448\u9012\u7ec6\u80de\uff08APC\uff09\u4e4b\u95f4\uff0c\u6216T\u7ec6\u80de\u4e0e\u652f\u6491\u7684\u5e73\u9762\u8102\u8d28\u53cc\u5206\u5b50\u5c42\u4e4b\u95f4\uff0c\u63a8\u65ad\u51fakon\u548ckoff\u52a8\u529b\u5b66\u3002\u56e0\u6b64\uff0c\u8fd9\u4e9b\u57fa\u4e8e\u8868\u9762\u7684\u819c\u76f8\u4e92\u4f5c\u7528\u88ab\u79f0\u4e3a\u201c\u4e8c\u7ef4\u76f8\u4e92\u4f5c\u7528\u201d\u30022D\u5206\u6790\u663e\u793a\u51fa\u4e0eT\u7ec6\u80de\u6d3b\u5316\u548c\u529f\u80fd\u6709\u5f88\u597d\u7684\u76f8\u5173\u6027\uff0c\u4f46\u5176kon\u548ckoff\u52a8\u529b\u5b66\u8981\u6bd43D SPR\u6280\u672f\u66f4\u5feb\u3002\u5c3d\u7ba12D\u65b9\u6cd5\u5141\u8bb8\u4ee5\u66f4\u63a5\u8fd1\u751f\u7406\u6761\u4ef6\u7684\u65b9\u5f0f\u6d4b\u91cfTCR-pMHC\u7ed3\u5408\u53c2\u6570\uff0c\u4f46\u4e24\u79cd\u65b9\u6cd5\u5e94\u88ab\u89c6\u4e3a\u9ad8\u5ea6\u4e92\u8865\u3002<\/p>\n

\u4e8b\u5b9e\u4e0a\uff0c2D\u5206\u6790\u9700\u8981\u4e13\u95e8\u8bbe\u5907\u4e14\u8f83\u4e3a\u8017\u65f6\uff0c\u8fd9\u59a8\u788d\u4e86\u5bf9\u6d3b\u6297\u539f\u7279\u5f02\u6027T\u7ec6\u80de\u7684\u5feb\u901f\u548c\u9ad8\u901a\u91cf\u7b5b\u9009\uff0c\u800c\u8fd9\u79cd\u7b5b\u9009\u53ef\u80fd\u5bf9\u8fc7\u7ee7\u7ec6\u80de\u514d\u75ab\u6cbb\u7597\u5177\u6709\u91cd\u8981\u610f\u4e49\u3002\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u6700\u8fd1\u7684\u4e00\u9879\u7814\u7a76\u6210\u529f\u6d4b\u91cf\u4e86\u5355\u7ec6\u80de2D TCR\u4eb2\u548c\u529b\uff0c\u5e76\u76f4\u63a5\u4ece\u4eba\u539f\u4ee3CD8 T\u7ec6\u80de\u4e2d\u8fdb\u884cTCR\u6d4b\u5e8f\uff0c\u4e3a\u5feb\u901f\u9009\u62e9\u4e2a\u4f53\u6cbb\u7597\u6027TCR\u4ee5\u7528\u4e8e\u8fc7\u7ee7\u7ec6\u80de\u8f6c\u79fb\u514d\u75ab\u6cbb\u7597\u94fa\u5e73\u4e86\u9053\u8def\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u968f\u7740\u53ef\u9006\u591a\u805a\u4f53\u7684\u5f00\u53d1\uff0c\u6280\u672f\u4e0a\u5b9e\u73b0\u4e86\u663e\u8457\u7684\u8fdb\u6b65\u3002\u53ef\u9006\u591a\u805a\u4f53\u5728\u7ed3\u6784\u4e0a\u7c7b\u4f3c\u4e8e\u4f20\u7edf\u591a\u805a\u4f53\uff0c\u4f46\u5b83\u4eec\u7684\u8bbe\u8ba1\u7279\u70b9\u662f\uff0c\u5f53\u52a0\u5165\u523a\u6fc0\u7269\u65f6\uff0cpMHC\u5355\u4f53\u53ef\u4ee5\u4ece\u591a\u805a\u4f53\u652f\u67b6\u4e0a\u91ca\u653e\u51fa\u6765\u3002\u53ef\u9006\u94fe\u4f53\u7531\u8367\u5149\u652f\u67b6\u5206\u5b50\uff08StrepTactin\uff09\u4e0e\u591a\u4e2a\u643a\u5e26\u94fe\u6807\u7b7e\uff08streptag\uff09\u7684pMHC\u5355\u4f53\u5076\u8054\u7ec4\u6210\u3002\u7531\u4e8eD-\u751f\u7269\u7d20\u4e0eStrepTactin\u7684\u7ed3\u5408\u4eb2\u548c\u529b\u9ad8\u4e8estreptag\uff0c\u5b83\u80fd\u591f\u7ade\u4e89\u7ed3\u5408\u4f4d\u70b9\uff0c\u7834\u574f\u591a\u805a\u4f53\u590d\u5408\u7269\u5e76\u5728\u7ec6\u80de\u8868\u9762\u91ca\u653epMHC\u5355\u4f53\u3002\u7531\u4e8epMHC\u5355\u4f53\u4e0d\u80fd\u7a33\u5b9a\u7ed3\u5408TCR\uff0c\u5b83\u4eec\u53ef\u4ee5\u8fc5\u901f\u4e0eTCR\u5206\u79bb\uff0c\u4ece\u800c\u8bc6\u522b\u5e76\u5206\u79bb\u771f\u6b63\u201c\u672a\u63a5\u89e6\u201d\u7684\u6297\u539f\u7279\u5f02\u6027CD8 T\u7ec6\u80de\uff0c\u540c\u65f6\u4fdd\u7559\u5176\u8868\u578b\u548c\u529f\u80fd\u72b6\u6001\u3002<\/p>\n

\u57fa\u4e8e\u7c7b\u4f3c\u539f\u7406\u7684\u53e6\u4e00\u79cd\u53ef\u9006\u591a\u805a\u4f53\u88ab\u79f0\u4e3aNTAmers\uff0c\u5b83\u7531\u5e26\u6709his\u6807\u7b7e\u7684pMHC\u4e0e\u643a\u5e26\u5de5\u7a0b\u5316\u785d\u57fa\u4e09\u4e59\u9178\uff08NTA\uff09\u8fde\u63a5\u5b50\u7684\u8367\u5149\u4eb2\u548c\u7d20\u8fde\u63a5\uff08\u89c1Fig 40.3a<\/span>\uff09\u3002\u5728\u52a0\u5165\u4f4e\u6d53\u5ea6\u4e14\u65e0\u6bd2\u7684\u54aa\u5511\u540e\uff0cNTA\u590d\u5408\u7269\u8fc5\u901f\u89e3\u4f53\u4e3apMHC\u5355\u4f53\uff0c\u4ece\u800c\u5141\u8bb8\u901a\u8fc7FACS\u5206\u9009\u6297\u539f\u7279\u5f02\u6027CD8 T\u7ec6\u80de\uff0c\u800c\u4e0d\u4f1a\u5bf9\u7ec6\u80de\u5b8c\u6574\u6027\u9020\u6210\u4e0d\u826f\u5f71\u54cd\uff0c\u5982\u6d3b\u5316\u8bf1\u5bfc\u7684\u7ec6\u80de\u6b7b\u4ea1\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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Fig. 40.3 <\/span>\u57fa\u4e8eNTAmers\u7684\u5355\u4f53\u89e3\u79bb\u5206\u6790\u7528\u4e8e\u9274\u5b9a\u5177\u6709\u66f4\u9ad8TCR-pMHC\u4eb2\u548c\u529b\u548c\u529f\u80fd\u6548\u529b\u7684\u6297\u80bf\u7624T\u7ec6\u80de<\/span><\/p>\n

(a) \u57fa\u4e8eNTAmers\u7684\u5355\u4f53\u89e3\u79bb\u5206\u6790\u793a\u610f\u56fe\u3002CD8 T\u7ec6\u80de\u901a\u8fc7NTAmers\u8fdb\u884c\u7a33\u5b9a\u67d3\u8272\uff0cNTAmers\u7531\u94fe\u9709\u4eb2\u548c\u7d20-PE\uff08\u7eff\u8272\uff09-NTA4\uff08\u7070\u8272\uff09\u548c\u542b\u6709Cy5\u6807\u8bb0\u7684\u03b22m\uff08\u7ea2\u8272\uff09\u7684\u80bd-MHC\uff08\u68d5\u8272\uff09\u5355\u4f53\u7ec4\u6210\u3002\u52a0\u5165\u54aa\u5511\u540e\uff0cNTAmers\u8fc5\u901f\u5728Cy5\u6807\u8bb0\u7684pMHC\u5355\u4f53\u4e2d\u89e3\u4f53\uff08\u4e2d\u95f4\u56fe\uff09\u3002\u6839\u636e\u56fa\u6709\u7684TCR\/CD8-pMHC\u89e3\u79bb\u901f\u7387\uff08koff\uff09\uff08\u53f3\u56fe\uff09\uff0cCy5\u6807\u8bb0\u7684pMHC\u5355\u4f53\u968f\u540e\u4ece\u4e0e\u7ec6\u80de\u76f8\u5173\u7684TCR\uff08\u9ed1\u8272\uff09\u548cCD8\uff08\u84dd\u8272\uff09\u89e3\u79bb\u3002<\/p>\n

(b) \u4ee3\u8868\u6027NTAmers\u89e3\u79bb\u67d3\u8272\u53ca\u5176\u76f8\u5e94\u7684\u62df\u5408\u66f2\u7ebf\u3002\u4eceCD8 T\u7ec6\u80de\u514b\u9686\u83b7\u5f97\u7684\u67d3\u8272\u6570\u636e\u5728\u5de6\u56fe\u4e2d\u5c55\u793a\uff0c\u800c\u53f3\u56fe\u4e3a\u76f8\u5e94\u7684\u62df\u5408\u66f2\u7ebf\uff0c\u5b9a\u4e49\u4e3aTCR-pMHC\u89e3\u79bb\u901f\u7387\uff08koff\uff09\u7684\u5feb\u6216\u6162\u3002\u57281\u5206\u949f\u57fa\u7ebf\u8bb0\u5f55\uff08\u767d\u8272\u95f4\u9699\uff09\u540e\uff0c\u52a0\u5165\u54aa\u5511\uff0c\u901a\u8fc7\u6d41\u5f0f\u7ec6\u80de\u672f\u89c2\u5bdf\u968f\u65f6\u95f4\u63a8\u79fb\u7684Cy5\uff08pMHC\u5355\u4f53\uff09\u548cPE\uff08NTA4\u652f\u67b6\uff09\u4fe1\u53f7\u7684\u89e3\u79bb\u66f2\u7ebf\u3002\u76f8\u5e94\u7684\u5355\u4f53\u89e3\u79bb\u901f\u7387\uff08koff\uff09\u901a\u8fc7Prism\uff08GraphPad\u8f6f\u4ef6\uff09\u8fdb\u884c\u5206\u6790\u3002<\/p>\n

(c) TCR-pMHC\u7ed3\u5408\u4eb2\u548c\u529b\u4e0eT\u7ec6\u80de\u529f\u80fd\u4eb2\u548c\u529b\u7684\u5173\u7cfb\u3002\u4ece\u4e00\u540d\u9ed1\u8272\u7d20\u7624\u60a3\u8005\uff08LAU618\uff09\u4e2d\u5206\u79bb\u51fa\u7684HLA-A2\/Melan-A\u7279\u5f02\u6027CD8 T\u7ec6\u80de\u514b\u9686\uff0c\u6839\u636e\u89e3\u79bb\u901f\u7387\uff08koff\uff09\u5206\u4e3a\u5feb\uff08\u767d\u8272\u5706\u5708\uff09\u548c\u6162\uff08\u9ed1\u8272\u65b9\u5757\uff09\u4e24\u7c7b\u3002\u5728\u5de6\u56fe\u4e2d\u5c55\u793a\u4e86\u57fa\u4e8eNTAmers\u7684\u5355\u4f53\u89e3\u79bb\u66f2\u7ebf\uff0c\u7b2c\u4e8c\u56fe\u5c55\u793a\u4e86\u57fa\u4e8eCD107a\u7684\u6ef4\u5b9a\u66f2\u7ebf\u3002\u7b2c\u4e09\u3001\u56db\u56fe\u5206\u522b\u5c55\u793a\u4e86TCR-pMHC\u4eb2\u5408\u529b\uff08\u5355\u4f53TCR-pMHC koff\uff09\u4e0e\u529f\u80fd\u4eb2\u5408\u529b\uff08CD107a\u8131\u9897\u7c92EC50\u548cIL-2\u4ea7\u751fEC50\uff09\u4e4b\u95f4\u7684\u76f8\u5173\u6027\uff08\u4ee5Spearman\u7cfb\u6570r\u548cP\u503c\u8868\u793a\uff09\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u7531\u4e8e\u8367\u5149\u6807\u8bb0\u4e86\u53ef\u9006\u591a\u805a\u4f53\u590d\u5408\u7269\u4e2d\u7684\u5355\u4e2apMHC\u5355\u4f53\uff0c\u6700\u8fd1\u7684\u6280\u672f\u53ef\u4ee5\u76f4\u63a5\u76d1\u6d4b\u5e76\u5b9a\u91cf\u5206\u6790\u6297\u539f\u7279\u5f02\u6027T\u7ec6\u80de\u8868\u9762\u7684pMHC\u5355\u4f53\u4e0eTCR\u7684\u89e3\u79bb\u60c5\u51b5\u3002\u901a\u8fc7\u57fa\u4e8e\u5b9e\u65f6\u663e\u5fae\u955c\u7684\u7b56\u7565\uff0c\u53ef\u9006\u53cc\u8272\u94fe\u4f53\u6210\u529f\u5730\u7528\u4e8e\u6d4b\u5b9a\u4eba\u7c7b\u548c\u5c0f\u9f20T\u7ec6\u80de\u4e0a\u975e\u81ea\u8eab\u75c5\u6bd2\u7279\u5f02\u6027TCR\u7684\u5355\u4f53\u89e3\u79bb\u52a8\u529b\u5b66\u3002<\/p>\n

\u5177\u4f53\u800c\u8a00\uff0cNauerth\u53ca\u5176\u540c\u4e8b\u62a5\u9053\uff0c\u4e0e\u534a\u8870\u671f\u8f83\u77ed\uff08\u9ad8koff\uff09\u7684T\u7ec6\u80de\u76f8\u6bd4\uff0c\u5177\u6709\u8f83\u957f\u534a\u8870\u671f\uff08\u4f4ekoff\uff09\u7684\u75c5\u6bd2\u7279\u5f02\u6027CD8 T\u7ec6\u80de\u5c55\u73b0\u51fa\u66f4\u9ad8\u7684\u529f\u80fd\u4eb2\u548c\u529b\u548c\u66f4\u5f3a\u7684\u4f53\u5185\u4fdd\u62a4\u80fd\u529b\u3002\u6b64\u5916\uff0cStreptamer\u6280\u672f\u7684\u4f18\u52bf\u5728\u4e8e\uff0c\u5b83\u80fd\u591f\u540c\u65f6\u68c0\u6d4b\u6570\u767e\u4e2a\u6297\u539f\u7279\u5f02\u6027CD8 T\u7ec6\u80de\u4e0a\u7684koff\u503c\uff0c\u4e0d\u53d7\u9650\u4e8e\u514b\u9686\u6027T\u7ec6\u80de\u7fa4\u7684\u4ea7\u751f\u3002\u7136\u800c\uff0cStreptamer\u89e3\u4f53\u4e3a\u5355\u4f53pMHC\u5206\u5b50\u6240\u9700\u7684\u663e\u8457\u5ef6\u8fdf\u65f6\u95f4\uff08\u7ea660\u79d2\uff09\u4ee5\u53ca\u4e0e\u663e\u5fae\u955c\u68c0\u6d4b\u76f8\u5173\u7684\u5149\u6f02\u767d\u6548\u5e94\uff0c\u9650\u5236\u4e86\u5feb\u901fTCR-pMHC\u8131\u9776\u7387\u7684\u68c0\u6d4b\uff0c\u800c\u8131\u9776\u7387\u901a\u5e38\u5728\u4f4e\u4eb2\u548c\u529b\u7684\u81ea\u8eab\/\u80bf\u7624\u7279\u5f02\u6027CD8 T\u7ec6\u80de\u4e2d\u53d1\u73b0\u3002<\/p>\n

\u6700\u8fd1\uff0c\u57fa\u4e8eStreptamer\u7684\u5b9e\u9a8c\u8fdb\u4e00\u6b65\u4f18\u5316\uff0c\u4f7f\u5f97\u901a\u8fc7\u5e38\u89c4\u6d41\u5f0f\u7ec6\u80de\u4eea\u6d4b\u91cf\u4f53\u5916\u672a\u5206\u9009\u7684\u591a\u514b\u9686\u6297\u539f\u7279\u5f02\u6027CD8 T\u7ec6\u80de\u7684koff\u503c\u6210\u4e3a\u53ef\u80fd\uff0c\u8fd9\u4e3a\u9ad8\u901a\u91cf\u5e94\u7528\u6253\u5f00\u4e86\u5927\u95e8\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u540c\u65f6\uff0c\u4f5c\u8005\u7684\u56e2\u961f\u4f7f\u7528\u4e86\u53ef\u9006NTAmer\u7684\u53cc\u8272\u7248\u672c\uff0c\u901a\u8fc7\u6d41\u5f0f\u7ec6\u80de\u4eea\u76f4\u63a5\u8bc4\u4f30\u6d3b\u4f53CD8 T\u7ec6\u80de\u4e0a\u7684TCR-pMHC\u89e3\u79bb\u52a8\u529b\u5b66\uff08\u89c1Fig 40.3a, b<\/span>\uff09\u3002NTAmer\u65b9\u6cd5\u7684\u51c6\u786e\u6027\u5f97\u5230\u4e86\u9a8c\u8bc1\uff0c\u7814\u7a76\u53d1\u73b0\u57fa\u4e8eNTAmer\u7684\u5355\u4f53\u89e3\u79bb\u7387\u4e0eSPR\u6d4b\u91cf\u7ed3\u679c\u4e4b\u95f4\u5177\u6709\u9ad8\u5ea6\u76f8\u5173\u6027\u3002\u4e0eStreptamer\u6280\u672f\u76f8\u6bd4\uff0cNTAmer\u652f\u67b6\u7684\u964d\u89e3\u901f\u5ea6\u66f4\u5feb\uff082-3\u79d2\uff09\uff0c\u8fd9\u4f7f\u5f97\u5bf9\u5e7f\u8c31TCR\u4eb2\u548c\u529b\u89e3\u79bb\u52a8\u529b\u5b66\u7684\u7cbe\u786e\u5206\u6790\u6210\u4e3a\u53ef\u80fd\uff0c\u5c24\u5176\u662f\u9488\u5bf9\u81ea\u8eab\/\u80bf\u7624\u7279\u5f02\u6027CD8 T\u7ec6\u80de\u7684\u89e3\u79bb\u52a8\u529b\u5b66\uff0c\u5b83\u4eec\u901a\u5e38\u8868\u73b0\u51fa\u4f4e\u4eb2\u548c\u529b\u548c\u5feb\u901fkoff\uff08\u89c1Fig 40.3c<\/span>\uff09\u3002<\/p>\n

\u603b\u800c\u8a00\u4e4b\uff0c\u53cc\u8272\u53ef\u9006\u591a\u805a\u4f53\u6280\u672f\uff08\u5373Streptamer\u548cNTAmer\uff09\u80fd\u591f\u5728\u5927\u91cf\u975e\u81ea\u8eab\/\u75c5\u6bd2\u548c\u81ea\u8eab\/\u80bf\u7624\u6297\u539f\u7279\u5f02\u6027CD8 T\u7ec6\u80de\u514b\u9686\u5185\uff0c\u76f4\u63a5\u5728\u6d3b\u4f53\u539f\u4ee3CD8 T\u7ec6\u80de\u8868\u9762\u5b9e\u65f6\u5b9a\u91cf\u5355\u4f53TCR-pMHC\u89e3\u79bb\u52a8\u529b\u5b66\u3002\u7136\u800c\uff0c\u5f53\u524d\u4ecd\u672a\u51fa\u73b0\u57fa\u4e8e\u5355\u4f53pMHC\u7684\u68c0\u6d4b\u65b9\u6cd5\uff0c\u80fd\u591f\u76f4\u63a5\u5bf9\u6d3b\u4f53T\u7ec6\u80de\u4e0a\u7684kon\u5173\u8054\u52a8\u529b\u5b66\u6216KD\u4eb2\u548c\u529b\u8fdb\u884c\u7cbe\u786e\u6d4b\u91cf\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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<\/p>\n<\/section>\n<\/section>\n

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40.6 TCR-pMHC\u7ed3\u5408\u53c2\u6570\u4e0eCD8 T\u7ec6\u80de\u6548\u529b\u4e4b\u95f4\u7684\u5173\u7cfb<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
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TCR\u4e0e\u6297\u539f\u4e4b\u95f4\u7684\u6709\u6548\u76f8\u4e92\u4f5c\u7528\u662f\u6210\u529f\u542f\u52a8\u548c\u53d1\u5c55\u9002\u5e94\u6027\u514d\u75ab\u5e94\u7b54\u7684\u5173\u952e\u3002\u7136\u800c\uff0c\u76ee\u524d\u5bf9\u5185\u6e90\u6027TCR-pMHC\u7ed3\u5408\u53c2\u6570\u7684\u5927\u89c4\u6a21\u8bc4\u4f30\u4ecd\u7136\u5177\u6709\u6280\u672f\u6311\u6218\u6027\uff0c\u8fd9\u9650\u5236\u4e86\u6211\u4eec\u5bf9TCR-pMHC\u4eb2\u548c\u529b\/\u4eb2\u5408\u529b\u5728\u5929\u7136\u81ea\u8eab\/\u80bf\u7624\u7279\u5f02\u6027CD8 T\u7ec6\u80de\u5e94\u7b54\u4e2d\u7684\u5f71\u54cd\u548c\u4e34\u5e8a\u76f8\u5173\u6027\u7684\u4e86\u89e3\u3002\u7279\u522b\u662f\uff0c\u5c1a\u4e0d\u6e05\u695a\u9ad8TCR-pMHC\u4eb2\u548c\u529b\/\u4eb2\u5408\u529b\u7684T\u7ec6\u80de\u662f\u5426\u5b58\u5728\u4e8e\u764c\u75c7\u60a3\u8005\u7684\u5185\u6e90\u6027\u80bf\u7624\u7279\u5f02\u6027\u5e93\u4e2d\uff0c\u4ee5\u53caTCR-pMHC\u4eb2\u548c\u529b\/\u4eb2\u5408\u529b\u53c2\u6570\u662f\u5426\u662f\u5f3a\u5927\u6297\u80bf\u7624T\u7ec6\u80de\u53cd\u5e94\u7684\u51b3\u5b9a\u6027\u56e0\u7d20\uff0c\u4ecd\u7136\u662f\u4e00\u4e2a\u5f00\u653e\u7684\u95ee\u9898\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u5728\u8fc7\u53bb\u768420\u5e74\u4e2d\uff0c\u8bb8\u591a\u7814\u7a76\u901a\u8fc7\u4f7f\u7528\u5b9e\u9a8c\u6027\u6539\u53d8\u7684\u80bd\u914d\u4f53\u6216\u4eb2\u548c\u529b\u4f18\u5316\u7684TCR\u53d8\u5f02\u4f53\uff0c\u6765\u9610\u660eTCR-pMHC\u7ed3\u5408\u53c2\u6570\u4e0eCD8 T\u7ec6\u80de\u529f\u80fd\u4e4b\u95f4\u7684\u5173\u8054\u673a\u5236\u3002\u8fd9\u4e9b\u7814\u7a76\u8868\u660e\uff0c\u5728\u751f\u7406\u76f8\u4e92\u4f5c\u7528\u8303\u56f4\u5185\uff08KD 200 \u03bcM – 1 \u03bcM\uff09\uff0cTCR-pMHC\u4eb2\u548c\u529b\uff08\u7531SPR\u786e\u5b9a\uff09\u4e0eT\u7ec6\u80de\u529f\u80fd\u4eb2\u548c\u529b\u5bc6\u5207\u76f8\u5173\u3002\u529f\u80fd\u6307\u6807\u5305\u62ecT\u7ec6\u80de\u4e0e\u9776\u7ec6\u80de\u7ed3\u5408\u7684\u6f5c\u80fd\u3001TCR\u4fe1\u53f7\u590d\u5408\u4f53\u4e0b\u6e38\u5206\u5b50\u7684\u78f7\u9178\u5316\u3001\u7ec6\u80de\u5185Ca\u00b2\u207a\u52a8\u5458\u3001\u88c2\u89e3\u9897\u7c92\u6781\u5316\u3001\u9776\u7ec6\u80de\u6740\u4f24\u3001\u7ec6\u80de\u56e0\u5b50\u4ea7\u751f\u3001\u7ec6\u80de\u589e\u6b96\u3001\u591a\u529f\u80fd\u6027\uff0c\u4ee5\u53ca\u4f53\u5185\u80bf\u7624\u6d78\u6da6\u548c\u4fdd\u62a4\/\u751f\u5b58\u80fd\u529b\u3002<\/p>\n

\u603b\u4e4b\uff0c\u8fd9\u4e9b\u7814\u7a76\u4e3a\u6839\u636eTCR-pMHC\u7ed3\u5408\u53c2\u6570\u8c03\u63a7\u80bf\u7624\u7279\u5f02\u6027T\u7ec6\u80de\u529f\u80fd\u6548\u529b\u63d0\u4f9b\u4e86\u6709\u529b\u8bc1\u636e\u3002\u7136\u800c\uff0c\u8fd9\u4e9b\u4eba\u5de5\u6a21\u578b\u53ef\u80fd\u7ed5\u8fc7\u4e86\u8bb8\u591a\u5176\u4ed6\u5206\u5b50\u548c\u7ec6\u80de\u53c2\u6570\uff0c\u8fd9\u4e9b\u53c2\u6570\u53ef\u80fd\u4f1a\u524a\u5f31TCR-pMHC\u4eb2\u548c\u529b\u5bf9\u603b\u4f53T\u7ec6\u80de\u529f\u80fd\u7684\u5f71\u54cd\u3002\u56e0\u6b64\uff0cTCR-pMHC\u4eb2\u548c\u529b\/\u4eb2\u5408\u529b\u662f\u5426\u662f\u5929\u7136\u6297\u80bf\u7624CD8 T\u7ec6\u80de\u5e94\u7b54\u7684\u51b3\u5b9a\u6027\u56e0\u7d20\uff0c\u4ecd\u6709\u5f85\u8fdb\u4e00\u6b65\u9a8c\u8bc1\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u56e0\u6b64\uff0c\u8bc4\u4f30TCR-pMHC\u7ed3\u5408\u6d3b\u6027\u80fd\u591f\u5e2e\u52a9\u6211\u4eec\u5728\u6bd4\u8f83\u5b9e\u9a8c\u4e2d\u786e\u5b9a\u54ea\u79cd\u6cbb\u7597\u6027\u75ab\u82d7\u65b9\u6848\u80fd\u591f\u89e6\u53d1\u6700\u6709\u6548\u7684\u80bf\u7624\u7279\u5f02\u6027T\u7ec6\u80de\u53cd\u5e94\uff0c\u4e3a\u672a\u6765\u764c\u75c7\u75ab\u82d7\u7684\u80bd\u9009\u62e9\u63d0\u4f9b\u5b9d\u8d35\u7684\u89c1\u89e3\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u901a\u8fc7\u66f4\u597d\u5730\u7406\u89e3\u514d\u75ab\u4fdd\u62a4\u7684\u76f8\u5173\u6027\uff0c\u5e76\u5f00\u53d1\u51fa\u80fd\u591f\u9009\u62e9\u51fa\u6700\u4f73\u80bf\u7624\u7279\u5f02\u6027CD8 T\u7ec6\u80de\uff08\u5373\u9ad8\u4eb2\u548c\u529b\u548c\u9ad8\u529f\u80fd\uff09\u7684\u65b0\u6280\u672f\uff0c\u6211\u4eec\u6709\u671b\u63a8\u52a8\u57fa\u4e8eT\u7ec6\u80de\u7684\u6297\u764c\u7597\u6cd5\u7684\u8fdb\u4e00\u6b65\u53d1\u5c55\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u672c\u6587\u7531Oncolab\u5fae\u4fe1\u516c\u4f17\u53f7\u7ffb\u8bd1\u6574\u7406\u81eaOncoimmunology: A Practical Guide for Cancer Immunotherapy\uff0c\u4ec5\u7528\u4e8e\u5b66\u4e60\u4ea4\u6d41\u4f7f\u7528\uff0c\u5982\u9700\u8d2d\u4e70\u539f\u7248\u4e66\u7c4d\u53ef\u70b9\u51fb\u9605\u8bfb\u539f\u6587\u8d2d\u4e70\u3002<\/span>
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\u2014 THE  END \u2014<\/span><\/p>\n


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\u6765\u6e90 | Oncoimmunology: A Practical Guide <\/span><\/p>\n

for Cancer Immunotherapy<\/span><\/p>\n

\u521d\u7a3f\u7ffb\u8bd1 | \u4f55\u4e3d\u5a1c<\/span><\/p>\n

\u56fe\u6587\u6392\u7248 | \u8d75\u6829 \u9ea6\u601d\u6dcb<\/span><\/span><\/p>\n

\u5ba1\u6838\u4fee\u6539 | \u738b\u5764<\/span><\/p>\n

\uff08\u8f6c\u8f7d\u8bf7\u4fdd\u7559\u6b64\u90e8\u5206\u5185\u5bb9\uff09<\/span><\/strong><\/p>\n


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\u2589  \u5f80\u671f\u63a8\u9001\u5408\u8f91<\/strong><\/strong><\/section>\n
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\u5e38\u7528\u5b9e\u9a8c<\/span>\u4eea\u5668\u7b80\u4ecb\u53ca\u64cd\u4f5c\u89c6\u9891<\/span><\/a><\/span><\/p>\n

\u5e38\u7528\u7535\u8111\u8f6f\u4ef6\u4f7f\u7528\u6559\u7a0b<\/span><\/a><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u52a0\u5165\u8bfb\u8005\u4ea4\u6d41\u7fa4~<\/span><\/p>\n

\uff08\u6dfb\u52a0\u8bf7\u5907\u6ce8\u5355\u4f4d\u59d3\u540d\uff09<\/span><\/p>\n


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\u52a0\u5165\u77e5\u8bc6\u661f\u7403~<\/span><\/p>\n


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\u70b9\u4eae\u8d5e\u4e0e\u5728\u770b <\/span><\/p>\n

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\u672c\u7bc7\u6587\u7ae0\u6765\u6e90\u4e8e\u5fae\u4fe1\u516c\u4f17\u53f7:OncoLab<\/p>\n<\/blockquote>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

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