{"id":5743,"date":"2024-10-02T07:00:45","date_gmt":"2024-10-01T23:00:45","guid":{"rendered":"http:\/\/dh.oncolab.cn\/index.php\/2024\/10\/02\/%e8%82%bf%e7%98%a4%e5%85%8d%e7%96%ab%e5%ad%a6-%e7%ac%ac41%e7%ab%a0-%e8%a1%80%e6%b6%b2%e5%92%8c%e8%82%bf%e7%98%a4%e5%be%ae%e7%8e%af%e5%a2%83%e7%9a%84%e5%85%8d%e7%96%ab%e7%9b%91%e6%b5%8b%ef%bc%88-2\/"},"modified":"2024-10-02T07:00:45","modified_gmt":"2024-10-01T23:00:45","slug":"%e8%82%bf%e7%98%a4%e5%85%8d%e7%96%ab%e5%ad%a6-%e7%ac%ac41%e7%ab%a0-%e8%a1%80%e6%b6%b2%e5%92%8c%e8%82%bf%e7%98%a4%e5%be%ae%e7%8e%af%e5%a2%83%e7%9a%84%e5%85%8d%e7%96%ab%e7%9b%91%e6%b5%8b%ef%bc%88-2","status":"publish","type":"post","link":"http:\/\/dh.oncolab.cn\/index.php\/2024\/10\/02\/%e8%82%bf%e7%98%a4%e5%85%8d%e7%96%ab%e5%ad%a6-%e7%ac%ac41%e7%ab%a0-%e8%a1%80%e6%b6%b2%e5%92%8c%e8%82%bf%e7%98%a4%e5%be%ae%e7%8e%af%e5%a2%83%e7%9a%84%e5%85%8d%e7%96%ab%e7%9b%91%e6%b5%8b%ef%bc%88-2\/","title":{"rendered":"\u80bf\u7624\u514d\u75ab\u5b66-\u7b2c41\u7ae0 \u8840\u6db2\u548c\u80bf\u7624\u5fae\u73af\u5883\u7684\u514d\u75ab\u76d1\u6d4b\uff08\u4e0b\uff09"},"content":{"rendered":"
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\u4e0a\u671f\u5185\u5bb9\uff1a\u80bf\u7624\u514d\u75ab\u5b66-\u7b2c41\u7ae0 \u8840\u6db2\u548c\u80bf\u7624\u5fae\u73af\u5883\u7684\u514d\u75ab\u76d1\u6d4b\uff08\u4e0a\uff09<\/span><\/a><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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41.4 \u591a\u91cd\u514d\u75ab\u7ec4\u7ec7\u5316\u5b66(IHC)\u68c0\u6d4b<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u7ec4\u7ec7\u5b66\u548c\u514d\u75ab\u7ec4\u5316\uff08IHC\uff09\u662f\u7814\u7a76\u5404\u79cd\u7ec4\u7ec7\u4e2d\u590d\u6742\u751f\u7269\u8fc7\u7a0b\u7684\u6781\u4f73\u5de5\u5177\u3002\u5bf9\u4e8e\u764c\u75c7\u60a3\u8005\u800c\u8a00\uff0c\u4e3b\u8981\u6311\u6218\u5728\u4e8e\u7406\u89e3\u80bf\u7624\u5fae\u73af\u5883\uff08TME\uff09\u4e2d\u9a71\u52a8\u75be\u75c5\u7684\u751f\u7269\u5b66\u673a\u5236\u3002\u57fa\u4e8e\u663e\u5fae\u955c\u7684\u7ec4\u7ec7\u5206\u6790\u53ef\u4ee5\u8bc6\u522b\u7ec4\u7ec7\u4e2d\u7684\u7ed3\u6784\u548c\u529f\u80fd\u5206\u5b50\uff0c\u5e76\u786e\u5b9a\u5b83\u4eec\u5728\u7ec6\u80de\u5185\u6216\u7ec6\u80de\u5916\u7684\u5b9a\u4f4d\u3002\u5206\u6790\u53ef\u4ee5\u4f7f\u7528\u65b0\u9c9c\u51b0\u51bb\uff08FF\uff09\u6216\u798f\u5c14\u9a6c\u6797\u56fa\u5b9a\u77f3\u8721\u5305\u57cb\uff08FFPE\uff09\u7684\u7ec4\u7ec7\u6837\u672c\u8fdb\u884c\uff0c\u5173\u952e\u5728\u4e8e\u6837\u672c\u7684\u9002\u5f53\u5904\u7406\uff0c\u4ee5\u907f\u514d\u86cb\u767d\u8d28\u548c\u6838\u9178\u635f\u4f24\u3002\u4e3a\u4fdd\u6301\u751f\u7269\u5206\u5b50\u5b8c\u6574\u6027\uff0c\u9700\u8981\u91c7\u53d6\u8c28\u614e\u7684\u5904\u7406\u6b65\u9aa4\uff0c\u5e76\u786e\u4fdd\u8d28\u91cf\u63a7\u5236\uff0c\u5305\u62ec\u9a8c\u8bc1\u67d3\u8272\u662f\u5426\u80fd\u591f\u6b63\u786e\u663e\u793a\u76ee\u6807\u6807\u8bb0\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u514d\u75ab\u7ec4\u5316\u6280\u672f\u4f7f\u7528\u6297\u4f53\u5bf9\u7ec4\u7ec7\u5207\u7247\u4e2d\u7684\u5206\u5b50\u8fdb\u884c\u7279\u5f02\u6027\u6807\u8bb0\u548c\u67d3\u8272\u3002\u6297\u4f53\u7ed3\u5408\u901a\u8fc7\u9176\u53cd\u5e94\uff08\u901a\u5e38\u5728\u5355\u4e2a\u7ec4\u7ec7\u5207\u7247\u4e0a\u6807\u8bb0\u4e09\u5230\u56db\u4e2a\uff09\u6216\u8367\u5149\u67d3\u6599\uff08\u6700\u591a\u6807\u8bb0\u516b\u4e2a\uff09\u6765\u68c0\u6d4b\u3002\u4e3a\u51cf\u5c11\u540e\u7eed\u67d3\u8272\u4e2d\u7684\u4ea4\u53c9\u53cd\u5e94\uff0c\u5e38\u4f7f\u7528\u4fe1\u53f7\u653e\u5927\u6280\u672f\u6765\u5171\u4ef7\u8fde\u63a5\u6297\u4f53\u548c\u67d3\u6599\u3002\u4f7f\u7528\u591a\u5149\u8c31\u76f8\u673a\u53ef\u4ee5\u8bc6\u522b\u8fd9\u4e9b\u6807\u8bb0\u7269\u3002\u6b64\u5916\uff0c\u65b0\u7684\u6280\u672f\u80fd\u591f\u901a\u8fc7\u8367\u5149\u56e2\u7684\u8fde\u7eed\u67d3\u8272\u3001\u626b\u63cf\u3001\u79fb\u9664\uff08\u6f02\u767d\uff09\u7b49\u5faa\u73af\u6b65\u9aa4\uff0c\u6807\u8bb0\u66f4\u591a\u5206\u5b50\uff08\u53ef\u80fd\u8d85\u8fc7100\u4e2a\uff09\uff0c\u4e0d\u8fc7\u8fd9\u9700\u8981\u7279\u5b9a\u8f6f\u4ef6\u6765\u8986\u76d6\u548c\u5206\u6790\u5e8f\u5217\u56fe\u50cf\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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IHC \u901a\u5e38\u5728\u4f20\u7edf\u7684\u7ec4\u7ec7\u5207\u7247\u4e0a\u8fdb\u884c\uff0c\u800c\u4e00\u79cd\u66ff\u4ee3\u65b9\u6cd5\u662f\u4f7f\u7528\u7ec4\u7ec7\u5fae\u9635\u5217\u3002\u8fd9\u79cd\u65b9\u6cd5\u901a\u8fc7\u5c06\u76f4\u5f840.6-2 mm\u7684\u7ec4\u7ec7\u5706\u67f1\u4f53\u63d2\u5165\u77f3\u8721\u5757\uff0c\u80fd\u591f\u6839\u636e\u5047\u8bbe\u548c\u5b9e\u9a8c\u8bbe\u8ba1\u9009\u62e9\u7279\u5b9a\u7684\u7ec4\u7ec7\u533a\u57df\u3002\u5229\u7528\u8fd9\u4e9b\u7ec4\u7ec7\u5fae\u9635\u5217\u5757\uff0c\u53ef\u4ee5\u5728\u4e00\u4e2a\u77f3\u8721\u5757\u4e2d\u5305\u542b\u591a\u8fbe100\u540d\u60a3\u8005\u7684\u7ec4\u7ec7\uff0c\u6781\u5927\u5730\u63d0\u9ad8\u4e86\u67d3\u8272\u6548\u7387\uff0c\u975e\u5e38\u9002\u5408\u5927\u89c4\u6a21\u5b9a\u91cf\u7814\u7a76\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u4f20\u7edf\u4e0a\uff0c\u7ec4\u7ec7\u56fe\u50cf\u7684\u5206\u6790\u548c\u89e3\u91ca\u7531\u8bad\u7ec3\u6709\u7d20\u7684\u75c5\u7406\u5b66\u5bb6\u901a\u8fc7\u663e\u5fae\u955c\u8fdb\u884c\u5b9a\u6027\u548c\u534a\u5b9a\u91cf\u8bc4\u4f30\u3002\u7136\u800c\uff0c\u968f\u7740\u81ea\u52a8\u56fe\u50cf\u5206\u6790\u8f6f\u4ef6\u7684\u51fa\u73b0\uff0c\u8d8a\u6765\u8d8a\u591a\u7684\u5206\u6790\u8fc7\u7a0b\u53ef\u4ee5\u88ab\u81ea\u52a8\u5316\uff0c\u4ece\u800c\u5bf9\u5927\u91cf\u7ec4\u7ec7\u533a\u57df\u8fdb\u884c\u5b8c\u5168\u5b9a\u91cf\u7684\u8bc4\u4f30\u3002\u5c3d\u7ba1\u5982\u6b64\uff0c\u75c5\u7406\u5b66\u5bb6\u7684\u76d1\u7763\u4ecd\u7136\u662f\u5fc5\u4e0d\u53ef\u5c11\u7684\uff0c\u4ee5\u786e\u4fdd\u5bf9\u7ec4\u7ec7\u590d\u6742\u6027\u7684\u6b63\u786e\u89e3\u8bfb\u548c\u8d28\u91cf\u63a7\u5236\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u603b\u800c\u8a00\u4e4b\uff0c\u4f7f\u7528\u9ad8\u6548\u548c\u7cbe\u51c6\u7684\u65b9\u6cd5\u5bf9\u7ec4\u7ec7\u8fdb\u884c\u5206\u6790\u662f\u7814\u7a76\u548c\u60a3\u8005\u8bc4\u4f30\u7684\u6838\u5fc3\u652f\u67f1\u3002\u4f8b\u5982\uff0c\u5728\u764c\u75c7\u7814\u7a76\u4e2d\uff0c\u5b9a\u91cf\u80bf\u7624\u6d78\u6da6\u6027T\u6dcb\u5df4\u7ec6\u80de\uff08TIL\uff09\u662f\u6781\u4e3a\u91cd\u8981\u7684\uff0c\u5b83\u4eec\u5f80\u5f80\u5177\u6709\u5f88\u9ad8\u7684\u9884\u540e\u548c\u9884\u6d4b\u4ef7\u503c\uff0c\u6709\u65f6\u751a\u81f3\u6bd4\u4f20\u7edf\u7684TNM\u5206\u671f\uff08\u80bf\u7624\u3001\u6dcb\u5df4\u7ed3\u3001\u8f6c\u79fb\uff09\u66f4\u5177\u53c2\u8003\u610f\u4e49\u3002\u8fd9\u4e9b\u6280\u672f\u8fd8\u5141\u8bb8\u5bf9\u80bf\u7624\u7ec6\u80de\u5de2\u3001\u4fb5\u88ad\u8fb9\u7f18\u6216\u80bf\u7624\u5468\u56f4\u533a\u57df\u7b49\u5b9a\u4e49\u533a\u57df\u4e2d\u7684TIL\u8fdb\u884c\u91cf\u5316\uff0c\u6bcf\u4e2a\u533a\u57df\u53ef\u80fd\u5177\u6709\u4e0d\u540c\u7684\u751f\u7269\u5b66\u610f\u4e49\u548c\u4e34\u5e8a\u7ed3\u679c\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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41.5 \u9ad8\u901a\u91cf\u6280\u672f<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u591a\u79cd\u9ad8\u901a\u91cf\u6280\u672f\u80fd\u591f\u540c\u65f6\u68c0\u6d4b\u6570\u5343\u4e2a\u53c2\u6570\uff0c\u56e0\u6b64\u5e7f\u6cdb\u7528\u4e8e\u80bf\u7624\u7814\u7a76\u4e2d\uff08\u5982Fig. 41.5<\/span>\u6240\u793a\uff09\uff0c\u7279\u522b\u662f\u57fa\u4e8e\u6d4b\u5e8f\u7684\u65b9\u6cd5\u3002\u5168\u5916\u663e\u5b50\u7ec4\u6d4b\u5e8f\uff08WES\uff09 \u662f\u8bc6\u522b\u80bf\u7624\u7ec6\u80de\u57fa\u56e0\u5f02\u5e38\u7684\u5173\u952e\u5de5\u5177\uff0c\u5b83\u80fd\u591f\u63ed\u793a\u7279\u5b9a\u7684\u57fa\u56e0\u7a81\u53d8\u548c\u603b\u4f53\u7a81\u53d8\u8d1f\u8377\u3002\u5f53WES\u4e0eDNA\u62f7\u8d1d\u6570\u5206\u6790\u7ed3\u5408\u65f6\uff0c\u53ef\u4ee5\u63d0\u4f9b\u80bf\u7624\u7ec6\u80de\u57fa\u56e0\u53d8\u5316\u7684\u5168\u9762\u6982\u89c8\uff0c\u63ed\u793a\u5176\u662f\u5426\u5f15\u53d1\u4e86\u529f\u80fd\u6027\u53d8\u5316\u3002<\/p>\n

\u53e6\u4e00\u79cd\u65e5\u76ca\u91cd\u8981\u7684\u6280\u672f\u662fRNA\u6d4b\u5e8f\uff08RNA-seq\uff09\uff0c\u5b83\u80fd\u591f\u5b9a\u91cf\u8bc4\u4f30mRNA\u6216microRNA\u7684\u8868\u8fbe\u3002\u8fd9\u9879\u6280\u672f\u5e7f\u6cdb\u5e94\u7528\u4e8e\u591a\u79cd\u7814\u7a76\u76ee\u7684\uff0c\u4f8b\u5982\u57fa\u56e0\u7b7e\u540d\u7814\u7a76\uff0c\u6216\u7528\u4e8e\u8868\u5f81\u8d8b\u5316\u56e0\u5b50\u3001\u7ec6\u80de\u56e0\u5b50\u53ca\u5176\u4ed6\u514d\u75ab\u56e0\u5b50\u7684\u8868\u8fbe\u3002\u6b64\u5916\uff0cDNA\u7532\u57fa\u5316\u56fe\u8c31\u53ef\u7528\u4e8e\u7814\u7a76\u8c03\u63a7\u514d\u75ab\u57fa\u56e0\u8868\u8fbe\u7684\u8868\u89c2\u9057\u4f20\u673a\u5236\uff0c\u4e5f\u53ef\u4ee5\u7528\u4e8e\u7279\u5b9a\u7ec6\u80de\u8c31\u7cfb\u7684\u8868\u89c2\u9057\u4f20\u4fee\u9970\uff0c\u4ece\u800c\u4f30\u7b97\u80bf\u7624\u5fae\u73af\u5883\u4e2d\u4e0d\u540c\u7ec6\u80de\u7fa4\u4f53\u7684\u6bd4\u4f8b\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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Fig. 41.5 <\/span>\u63cf\u7ed8\u4e86\u5229\u7528\u9ad8\u901a\u91cf\u6280\u672f\u8868\u5f81\u764c\u7ec6\u80de\u53ca\u5176\u5fae\u73af\u5883\u7684\u7b56\u7565\uff0c\u4ee5\u6539\u5584\u60a3\u8005\u7684\u8bca\u65ad\u548c\u6cbb\u7597\uff0c\u63a8\u52a8\u7cbe\u51c6\u533b\u5b66\u7684\u53d1\u5c55\u3002\u8d8a\u6765\u8d8a\u591a\u7684\u6280\u672f\u53ef\u4ee5\u5168\u9762\u8868\u5f81\u764c\u75c7\u60a3\u8005\u7684\u7ec4\u7ec7\u548c\u7ec6\u80de\uff0c\u4ece\u800c\u66f4\u8be6\u7ec6\u5730\u63cf\u7ed8\u539f\u53d1\u6027\u80bf\u7624\u548c\u8f6c\u79fb\u6027\u764c\u75c7\u7684\u80bf\u7624\u751f\u7269\u5b66\u53ca\u514d\u75ab\u53c2\u6570\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u7531\u4e8e\u8fd9\u4e9b\u9ad8\u901a\u91cf\u6280\u672f\u751f\u6210\u7684\u6570\u636e\u91cf\u5de8\u5927\uff0c\u6570\u636e\u7684\u5b58\u50a8\u3001\u5904\u7406\u3001\u7edf\u8ba1\u5206\u6790\u548c\u7ed3\u679c\u89e3\u91ca\u53d8\u5f97\u975e\u5e38\u590d\u6742\uff0c\u5fc5\u987b\u4f9d\u8d56\u751f\u7269\u4fe1\u606f\u5b66\u5de5\u5177\u6765\u8fdb\u884c\u652f\u6301\u3002\u8fd9\u9700\u8981\u5f3a\u5927\u7684\u786c\u4ef6\u548c\u4e13\u4e1a\u77e5\u8bc6\u3002\u4f8b\u5982\uff0cDNA\u5fae\u9635\u5217\u6570\u636e\u53ef\u4ee5\u901a\u8fc7BRB-Array Tools\u8fdb\u884c\u5206\u6790\uff0c\u8be5\u8f6f\u4ef6\u4e3a\u9884\u6d4b\u6027\u5206\u7c7b\u5668\u7684\u5f00\u53d1\u548c\u4ea4\u53c9\u9a8c\u8bc1\u63d0\u4f9b\u4e86\u5e7f\u6cdb\u7684\u5de5\u5177\u3002\u4e13\u95e8\u7684\u8f6f\u4ef6\u4e5f\u88ab\u7528\u4e8e\u7814\u7a76\u8868\u89c2\u9057\u4f20\u7f16\u7a0b\uff0c\u8fd9\u4e9b\u5de5\u5177\u5fc5\u987b\u4e25\u683c\u9075\u5b88\u6570\u5b66\u548c\u7edf\u8ba1\u89c4\u5219\uff0c\u4f8b\u5982\u5904\u7406\u591a\u91cd\u6d4b\u8bd5\u65f6\u7684\u5206\u6790\u539f\u5219\uff0c\u4ee5\u53ca\u5bf9\u5927\u89c4\u6a21\u6570\u636e\u7684\u7edf\u8ba1\u8bc4\u4f30\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u5927\u591a\u6570\u751f\u7269\u6837\u672c\u5305\u542b\u591a\u79cd\u4e0d\u540c\u6210\u5206\u7684\u7ec6\u80de\u7c7b\u578b\u3002\u4f8b\u5982\uff0c\u4e0d\u540c\u7ec4\u7ec7\u4e2d\u7684mRNA\u5e8f\u5217\u6570\u636e\u53ef\u80fd\u7531\u4e8e\u4e0d\u540c\u7ec6\u80de\u7c7b\u578b\u7684\u76f8\u5bf9\u6bd4\u4f8b\u5dee\u5f02\u800c\u6df7\u6dc6\u3002\u56e0\u6b64\uff0c\u5f00\u53d1\u4e86\u591a\u79cd\u53bb\u5377\u79ef\u7b97\u6cd5\uff0c\u65e8\u5728\u4f30\u7b97\u6837\u672c\u4e2d\u4e0d\u540c\u7ec6\u80de\u7fa4\u4f53\u7684\u6bd4\u4f8b\u3002\u6b64\u5916\uff0c\u5177\u6709\u4f53\u7ec6\u80de\u7a81\u53d8\u7684\u80bf\u7624\u6297\u539f\uff08\u65b0\u6297\u539f\uff09\u53ef\u4ee5\u901a\u8fc7\u591a\u79cd\u8f6f\u4ef6\u5de5\u5177\u8fdb\u884c\u9884\u6d4b\uff0c\u8fd9\u4e9b\u5de5\u5177\u7528\u4e8e\u9884\u6d4b\u6297\u539f\u7684\u52a0\u5de5\u548cMHC\u7ed3\u5408\u7b49\u56e0\u7d20\u3002\u4e0e\u5e38\u89c4\u7684\u81ea\u8eab\u6297\u539f\u76f8\u6bd4\uff0c\u80bf\u7624\u7279\u5f02\u6027T\u7ec6\u80de\u8bc6\u522b\u65b0\u6297\u539f\u901a\u5e38\u5177\u6709\u66f4\u597d\u7684\u7597\u6548\u3002<\/p>\n

\u7136\u800c\uff0c\u5fc5\u987b\u8c28\u614e\u5bf9\u5f85\u8fd9\u4e9b\u9884\u6d4b\uff0c\u56e0\u4e3a\u5927\u591a\u6570\u9884\u6d4b\u7684\u6297\u539f\u53ef\u80fd\u4e0e\u514d\u75ab\u5e94\u7b54\u65e0\u5173\uff0c\u5b83\u4eec\u53ef\u80fd\u672a\u88ab\u6709\u6548\u5448\u9012\u7ed9T\u7ec6\u80de\uff0c\u6216\u8005\u76f8\u5e94\u7684T\u7ec6\u80de\u5e76\u4e0d\u5b58\u5728\u3002\u56e0\u6b64\uff0c\u751f\u7269\u4fe1\u606f\u5b66\u7ed3\u679c\u59cb\u7ec8\u9700\u8981\u4e0e\u5b9e\u9a8c\u6570\u636e\u76f8\u7ed3\u5408\uff0c\u6700\u597d\u662f\u5728\u5927\u89c4\u6a21\u6570\u636e\u652f\u6301\u4e0b\u9a8c\u8bc1\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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<\/p>\n<\/section>\n<\/section>\n

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41.6 \u9a8c\u8bc1\u68c0\u6d4b\u65b9\u6cd5\u3001\u4e34\u5e8a\u4f7f\u7528\u7684\u751f\u7269\u6807\u5fd7\u7269\u53ca\u5927\u6570\u636e\u96c6\u6210<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
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\u4ece\u5b9e\u9a8c\u5ba4\u533b\u5b66\u8bde\u751f\u4e4b\u521d\uff0c\u907f\u514d\u9519\u8bef\u548c\u8bef\u89e3\uff0c\u4ee5\u53ca\u9632\u6b62\u8fc7\u5ea6\u89e3\u8bfb\uff0c\u5c31\u4e00\u76f4\u662f\u81f3\u5173\u91cd\u8981\u7684\u3002\u968f\u7740\u751f\u7269\u533b\u5b66\u5b9e\u9a8c\u5ba4\u7684\u5feb\u901f\u53d1\u5c55\u548c\u6d77\u91cf\u6570\u636e\u7684\u4ea7\u751f\uff0c\u8fd9\u4e00\u6982\u5ff5\u53d8\u5f97\u66f4\u52a0\u91cd\u8981\u3002\u8981\u8fbe\u5230\u4ee4\u4eba\u6ee1\u610f\u7684\u7cbe\u5ea6\u548c\u6807\u51c6\u5316\u6c34\u5e73\uff0c\u9700\u8981\u4ed8\u51fa\u5de8\u5927\u7684\u52aa\u529b\u3002\u5c24\u5176\u91cd\u8981\u7684\u662f\uff0c\u5b9e\u9a8c\u7ed3\u679c\u5fc5\u987b\u5bf9\u60a3\u8005\u7684\u5065\u5eb7\u6709\u5b9e\u9645\u610f\u4e49\uff0c\u800c\u8fd9\u5f80\u5f80\u53ea\u9002\u7528\u4e8e\u4e00\u5c0f\u90e8\u5206\u6570\u636e\uff0c\u56e0\u4e3a\u5927\u591a\u6570\u6570\u636e\u4e0e\u8bca\u65ad\u6216\u6cbb\u7597\u51b3\u7b56\u51e0\u4e4e\u6ca1\u6709\u663e\u8457\u5173\u8054\u3002<\/p>\n

\u4f17\u591a\u4e13\u5bb6\u548c\u5e7f\u6cdb\u7684\u6587\u732e\u4e3a\u8d1f\u8d23\u4efb\u5730\u5f00\u53d1\u5b9e\u9a8c\u5ba4\u65b9\u6cd5\u63d0\u4f9b\u4e86\u57fa\u7840\u3002\u4f8b\u5982\uff0c\u53d1\u8868\u5728\u300a\u764c\u75c7\u514d\u75ab\u6cbb\u7597\u6742\u5fd7\u300b\u4e0a\u7684\u4e00\u7bc7\u4e24\u5377\u672c\u8bba\u6587\uff0c\u6df1\u5165\u63a2\u8ba8\u4e86\u5982\u4f55\u9a8c\u8bc1\u751f\u7269\u6807\u5fd7\u7269\u4ee5\u9884\u6d4b\u764c\u75c7\u514d\u75ab\u6cbb\u7597\u7684\u53cd\u5e94\u3002\u6240\u6709\u5b9e\u9a8c\u7a0b\u5e8f\u3001\u5206\u6790\u548c\u7ed3\u679c\u5fc5\u987b\u5728\u4e34\u5e8a\u524d\u548c\u4e34\u5e8a\u4e0a\u8fdb\u884c\u9a8c\u8bc1\uff0c\u4e14\u5e38\u89c4\u4e34\u5e8a\u4f7f\u7528\u5fc5\u987b\u83b7\u5f97\u76d1\u7ba1\u673a\u6784\u7684\u6279\u51c6\u3002\u76ee\u524d\uff0c\u53ea\u6709\u4e09\u79cd\u68c0\u6d4b\u65b9\u6cd5\u5df2\u901a\u8fc7\u5ba1\u6279\uff0c\u8fd9\u4e9b\u65b9\u6cd5\u5747\u7528\u4e8e\u91cf\u5316PD-L1\u8868\u8fbe\uff08\u8be6\u89c1\u4e0b\u6587\uff09\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
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\u8d28\u91cf\u6807\u51c6\u9002\u7528\u4e8e\u6bcf\u4e00\u4e2a\u6b65\u9aa4\uff0c\u4ece\u63d0\u53d6\u5230\u5904\u7406\u8840\u6db2\u548c\u7ec4\u7ec7\u6837\u672c\u3002\u4f8b\u5982\uff0c\u65f6\u95f4\u5ef6\u8fdf\u548c\u4e0d\u5229\u7684\u5b58\u50a8\u6761\u4ef6\u53ef\u80fd\u4f1a\u5f71\u54cd\u6837\u672c\u7684\u8d28\u91cf\u3002\u6b64\u5916\uff0c\u73b0\u4ee3\u5b9e\u9a8c\u5ba4\u65b9\u6cd5\u6d89\u53ca\u5927\u91cf\u53d8\u91cf\uff0c\u8fd9\u4e9b\u53d8\u91cf\u90fd\u9700\u8981\u5b9a\u4e49\u548c\u6807\u51c6\u5316\uff0c\u4ee5\u786e\u4fdd\u5728\u4e0d\u540c\u673a\u6784\u4e4b\u95f4\u80fd\u591f\u83b7\u5f97\u9ad8\u5ea6\u91cd\u590d\u6027\u7684\u7ed3\u679c\u3002\u540c\u65f6\uff0c\u5206\u5e03\u53c2\u8003\u6837\u54c1\u5bf9\u65b9\u6cd5\u5f00\u53d1\u548c\u540e\u7eed\u7684\u5b9a\u671f\u6d4b\u8bd5\u540c\u6837\u91cd\u8981\u3002\u6700\u540e\uff0c\u5fc5\u987b\u901a\u8fc7\u4e34\u5e8a\u7814\u7a76\u786e\u5b9a\u4e34\u5e8a\u76f8\u5173\u6027\uff0c\u6700\u597d\u662f\u5728\u968f\u673a\u524d\u77bb\u6027\u8bd5\u9a8c\u4e2d\uff0c\u800c\u4e0d\u4ec5\u4ec5\u662f\u56de\u987e\u6027\u7814\u7a76\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
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\n

\u5df2\u7ecf\u5f00\u5c55\u4e86\u4e00\u4e9b\u524d\u77bb\u6027\u7814\u7a76\uff0c\u5c24\u5176\u662f\u8bc4\u4f30PD-L1\u5728\u60a3\u8005\u80bf\u7624\u4e2d\u7684\u8868\u8fbe\uff0c\u76ee\u7684\u662f\u9884\u6d4b\u6297PD-1\u6216\u6297PD-L1\u6297\u4f53\u8fdb\u884c\u201c\u68c0\u67e5\u70b9\u963b\u65ad\u201d\u6cbb\u7597\u7684\u6548\u679c\u3002\u6b64\u5916\uff0c\u514d\u75ab\u7ec4\u5316\uff08IHC\uff09\u6b63\u5728\u4e3a\u7ed3\u80a0\u764c\u60a3\u8005\u8fdb\u884cTIL\u91cf\u5316\u7684\u56fd\u9645\u591a\u4e2d\u5fc3\u6807\u51c6\u5316\u5de5\u4f5c\uff0c\u8fd9\u53ef\u80fd\u6210\u4e3a\u672a\u6765\u5bf9\u66f4\u591a\u764c\u75c7\u7c7b\u578b\u8fdb\u884c\u5e38\u89c4\u7ec4\u7ec7\u5b66\u8bc4\u4f30\u7684\u57fa\u7840\u3002\u8fd9\u6709\u671b\u5728\u4e0d\u4e45\u7684\u5c06\u6765\u5c06\u514d\u75ab\u53c2\u6570\u6574\u5408\u5230\u75be\u75c5\u5206\u671f\u548c\u6cbb\u7597\u65b9\u6848\u4e2d\u3002<\/p>\n

\u7136\u800c\uff0c\u6210\u529f\u5b9e\u73b0\u8fd9\u4e00\u76ee\u6807\u7684\u5173\u952e\u662f\u7ee7\u7eed\u52aa\u529b\u6807\u51c6\u5316\u8bc4\u4f30\u65b9\u6cd5\uff0c\u4ee5\u4fbf\u5728\u5404\u79cd\u4e34\u5e8a\u60c5\u5883\u4e2d\u51c6\u786e\u5e94\u7528\u8fd9\u4e9b\u514d\u75ab\u53c2\u6570\uff0c\u800c\u4e0d\u4ec5\u4ec5\u505c\u7559\u5728\u91cf\u5316TIL\u548cPD-L1\u8868\u8fbe\u7684\u521d\u6b65\u6b65\u9aa4\u4e0a\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
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\n

\u9664\u4e86\u5206\u6790\u4ea7\u751f\u5927\u91cf\u6570\u636e\u7684\u5b9e\u9a8c\u7684\u590d\u6742\u6027\u4e4b\u5916\uff0c\u53e6\u4e00\u4e2a\u5de8\u5927\u7684\u6311\u6218\u662f\u5c06\u6240\u6709\u5b9e\u9a8c\u5ba4\u7ed3\u679c\u4e0e\u6bcf\u4e2a\u60a3\u8005\u7684\u4e34\u5e8a\u4fe1\u606f\u76f8\u7ed3\u5408\uff0c\u4ee5\u786e\u4fdd\u505a\u51fa\u6700\u4f73\u7684\u4e34\u5e8a\u51b3\u7b56\u3002\u4e3a\u5b9e\u73b0\u8fd9\u4e00\u5927\u6570\u636e\u96c6\u6210\u7684\u76ee\u6807\uff0c\u8ba1\u7b97\u6280\u672f\u6b63\u5728\u5feb\u901f\u53d1\u5c55\uff0c\u4f8b\u5982IBM Watson\u7cfb\u7edf\u3002\u76ee\u524d\uff0c\u4e00\u4e2a\u4e13\u95e8\u4e3a\u764c\u75c7\u836f\u7269\u5b9a\u5236\u7684\u7248\u672c\uff08Watson\u80bf\u7624\u5b66\uff09\u6b63\u5728\u5f00\u53d1\u4e2d\u3002\u8fd9\u7c7b\u7cfb\u7edf\u6709\u5de8\u5927\u7684\u6f5c\u529b\uff0c\u4f46\u5176\u5b9e\u65bd\u4f9d\u8d56\u4e8e\u7d27\u5bc6\u7684\u591a\u5b66\u79d1\u5408\u4f5c\uff0c\u4ee5\u786e\u4fdd\u4e0d\u4ec5\u91c7\u7528\u6700\u4f73\u7684\u65b0\u65b9\u6cd5\u7ba1\u7406\u60a3\u8005\uff0c\u8fd8\u8981\u8003\u8651\u5230\u6240\u6709\u5f53\u524d\u7684\u77e5\u8bc6\u548c\u8d28\u91cf\u6807\u51c6\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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<\/p>\n<\/section>\n<\/section>\n

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41.7  \u7ed3\u8bba<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u514d\u75ab\u76d1\u6d4b\u5728\u8bb8\u591a\u5b9e\u9a8c\u5ba4\u4e2d\u90fd\u53ef\u4ee5\u8fdb\u884c\uff0c\u4f46\u5176\u6311\u6218\u5728\u4e8e\u5f00\u53d1\u548c\u5e94\u7528\u6807\u51c6\u5316\u7684\u6837\u672c\u5206\u6790\u65b9\u6cd5\u3002\u5904\u7406\u7ec6\u80de\u6750\u6599\u7684\u8fc7\u7a0b\u975e\u5e38\u7cbe\u7ec6\uff0c\u8981\u6c42\u64cd\u4f5c\u4eba\u5458\u7ecf\u8fc7\u4e13\u95e8\u57f9\u8bad\u3002\u4efb\u4f55\u5bf9\u6807\u51c6\u5de5\u4f5c\u6d41\u7a0b\u7684\u8f7b\u5fae\u504f\u5dee\u90fd\u4f1a\u663e\u8457\u5f71\u54cd\u6837\u672c\u7684\u8d28\u91cf\uff0c\u8fdb\u800c\u5f71\u54cd\u4e0d\u540c\u6280\u672f\u6240\u5f97\u7ed3\u679c\u7684\u51c6\u786e\u6027\u3002<\/p>\n

\u4e3a\u4e86\u89e3\u51b3\u8fd9\u4e00\u95ee\u9898\uff0c\u6807\u51c6\u5316\u7684\u65b9\u6cd5\u5b66\u548c\u7ed3\u679c\u62a5\u544a\u6307\u5357\u81f3\u5173\u91cd\u8981\uff0c\u8fd9\u4e9b\u6307\u5357\u6709\u52a9\u4e8e\u5728\u4e0d\u540c\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u66f4\u597d\u5730\u8868\u5f81\u548c\u6bd4\u8f83\u514d\u75ab\u53cd\u5e94\u3002\u4f8b\u5982\uff0c\u751f\u7269\u548c\u751f\u7269\u533b\u5b66\u8c03\u67e5\u7684\u6700\u4f4e\u4fe1\u606f\uff08MIBBI\uff09\u8ba1\u5212\u4e3a\u5b9e\u9a8c\u63d0\u4f9b\u4e86\u4e00\u4e2a\u6846\u67b6\uff0c\u5305\u542b\u4e86\u591a\u4e2a\u9879\u76ee\uff0c\u5982\u5173\u4e8e\u6d41\u5f0f\u7ec6\u80de\u672f\uff08Flow Cytometry\uff0c\u5229\u7528\u6fc0\u5149\u5206\u6790\u7ec6\u80de\u6027\u8d28\u7684\u6280\u672f\uff09\u7684\u6700\u4f4e\u4fe1\u606f\uff08MIFlowCyt\uff09\u3001\u5173\u4e8e\u7ec6\u80de\u68c0\u6d4b\u7684\u6700\u4f4e\u4fe1\u606f\uff08MIACA\uff09\u4ee5\u53ca\u5173\u4e8eT\u7ec6\u80de\u68c0\u6d4b\u7684\u6700\u4f4e\u4fe1\u606f\uff08MIA TA\uff09\u3002\u8fd9\u4e9b\u5efa\u8bae\u57fa\u4e8eNCI\uff08\u7f8e\u56fd\u56fd\u5bb6\u764c\u75c7\u7814\u7a76\u6240\uff09\u7684REMARK\u6807\u51c6\uff0c\u5373\u80bf\u7624\u6807\u8bb0\u7269\u9884\u540e\u7814\u7a76\u7684\u62a5\u544a\u5efa\u8bae\u3002<\/p>\n

\u4e3a\u4e86\u786e\u4fdd\u9ad8\u8d28\u91cf\u7684\u514d\u75ab\u76d1\u6d4b\uff0c\u591a\u673a\u6784\u8bd5\u9a8c\u901a\u5e38\u4f9d\u8d56\u4e8e\u4e00\u4e2a\u4e2d\u5fc3\u5b9e\u9a8c\u5ba4\u4ee5\u53ca\u5927\u89c4\u6a21\u7684\u4e34\u5e8a\u6807\u672c\u5e93\uff08\u6837\u672c\u50a8\u5b58\u8bbe\u65bd\uff09\uff0c\u4ee5\u4fbf\u672a\u6765\u80fd\u591f\u5bf9\u8840\u6e05\uff08\u8840\u6db2\u4e2d\u7684\u6db2\u4f53\u90e8\u5206\uff09\u3001\u6d3b\u7ec6\u80de\u3001RNA\uff08\u6838\u7cd6\u6838\u9178\uff0c\u9057\u4f20\u4fe1\u606f\u7684\u4f20\u9012\u8005\uff09\u548cDNA\u8fdb\u884c\u8fdb\u4e00\u6b65\u5206\u6790\u3002<\/p>\n

\u4e34\u5e8a\u548c\u5b9e\u9a8c\u5ba4\u4eba\u5458\u5fc5\u987b\u5171\u540c\u52aa\u529b\uff0c\u4e25\u683c\u6267\u884c\u73b0\u6709\u7684\u6807\u51c6\uff0c\u5e76\u5236\u5b9a\u66f4\u4f18\u7684\u539f\u5219\uff0c\u6700\u5927\u9650\u5ea6\u5730\u5229\u7528\u4e34\u5e8a\u8bd5\u9a8c\u7684\u6210\u679c\uff0c\u540c\u65f6\u652f\u6301\u66f4\u6709\u6548\u6cbb\u7597\u65b9\u6cd5\u7684\u5f00\u53d1\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u672c\u6587\u7531Oncolab\u5fae\u4fe1\u516c\u4f17\u53f7\u7ffb\u8bd1\u6574\u7406\u81eaOncoimmunology: A Practical Guide for Cancer Immunotherapy\uff0c\u4ec5\u7528\u4e8e\u5b66\u4e60\u4ea4\u6d41\u4f7f\u7528\uff0c\u5982\u9700\u8d2d\u4e70\u539f\u7248\u4e66\u7c4d\u53ef\u70b9\u51fb\u9605\u8bfb\u539f\u6587\u8d2d\u4e70\u3002<\/span>
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\u2014 THE  END \u2014<\/span><\/p>\n


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\u6765\u6e90 | Oncoimmunology: A Practical Guide <\/span><\/p>\n

for Cancer Immunotherapy<\/span><\/p>\n

\u521d\u7a3f\u7ffb\u8bd1 | \u5218\u7389\u5a07<\/span><\/p>\n

\u56fe\u6587\u6392\u7248 | \u8521\u5029\u8587 \u90d1\u5bb6\u6021<\/span><\/span><\/p>\n

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\uff08\u8f6c\u8f7d\u8bf7\u4fdd\u7559\u6b64\u90e8\u5206\u5185\u5bb9\uff09<\/span><\/strong><\/p>\n


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