{"id":5845,"date":"2024-08-29T11:41:04","date_gmt":"2024-08-29T03:41:04","guid":{"rendered":"http:\/\/dh.oncolab.cn\/index.php\/2024\/08\/29\/%e7%a5%9e%e7%bb%8f%e7%a7%91%e5%ad%a6%e5%8e%9f%e7%90%86-%e7%ac%ac2%e7%ab%a0-%e5%9f%ba%e5%9b%a0%e5%92%8c%e8%a1%8c%e4%b8%ba%ef%bc%88%e4%b8%8a%ef%bc%89\/"},"modified":"2024-08-29T11:41:04","modified_gmt":"2024-08-29T03:41:04","slug":"%e7%a5%9e%e7%bb%8f%e7%a7%91%e5%ad%a6%e5%8e%9f%e7%90%86-%e7%ac%ac2%e7%ab%a0-%e5%9f%ba%e5%9b%a0%e5%92%8c%e8%a1%8c%e4%b8%ba%ef%bc%88%e4%b8%8a%ef%bc%89","status":"publish","type":"post","link":"http:\/\/dh.oncolab.cn\/index.php\/2024\/08\/29\/%e7%a5%9e%e7%bb%8f%e7%a7%91%e5%ad%a6%e5%8e%9f%e7%90%86-%e7%ac%ac2%e7%ab%a0-%e5%9f%ba%e5%9b%a0%e5%92%8c%e8%a1%8c%e4%b8%ba%ef%bc%88%e4%b8%8a%ef%bc%89\/","title":{"rendered":"\u795e\u7ecf\u79d1\u5b66\u539f\u7406-\u7b2c2\u7ae0 \u57fa\u56e0\u548c\u884c\u4e3a\uff08\u4e0a\uff09"},"content":{"rendered":"<div class='wxsyncmain'>\n<section>\n<section>\n<section>\n<section>\n<section style=\"font-size: 16px;\">\n<section style=\"margin-top: 10px;margin-bottom: 10px;\">\n<section style=\"display: inline-block;width: 100%;border-width: 2px;border-style: dashed;border-color: rgb(164, 172, 181);padding: 10px;background-color: rgb(238, 249, 255);border-radius: 11.2px;overflow: hidden;\">\n<section style=\"color: rgb(0, 0, 0);\">\n<p style=\"text-wrap: wrap;\">\u4e0a\u671f\u5185\u5bb9\uff1a<a target=\"_blank\" href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzAwMDUzNTIxNA==&amp;mid=2456257662&amp;idx=1&amp;sn=e8ea33d7e81ea8120e70ed4d2dd6d05c&amp;chksm=8d745bbfba03d2a9abea40ae73764adf80873b3ac6a1aa66999012def5b831fba7e9d4087415&amp;scene=21#wechat_redirect\" textvalue=\"\u795e\u7ecf\u79d1\u5b66\u539f\u7406-\u7b2c1\u7ae0 \u5927\u8111\u548c\u884c\u4e3a\uff08\u4e0b\uff09\" linktype=\"text\" imgurl=\"\" imgdata=\"null\" data-itemshowtype=\"0\" tab=\"innerlink\" data-linktype=\"2\" rel=\"noopener\"><span style=\"color: rgb(21, 6, 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style=\"display: flex;flex-flow: row;margin: 20px 0% 10px;text-align: left;justify-content: flex-start;\">\n<section style=\"display: inline-block;vertical-align: middle;width: 15%;align-self: center;background-color: rgb(49, 116, 161);flex: 0 0 auto;height: auto;border-width: 0px;line-height: 1.4;\">\n<section style=\"text-align: justify;\">\n<p style=\"text-wrap: wrap;\"><br  \/><\/p>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: middle;width: auto;align-self: center;border-style: none;border-width: 0px;border-color: rgb(49, 116, 161) rgb(49, 116, 161) rgb(49, 116, 161) rgb(0, 137, 123);flex: 100 100 0%;height: auto;\">\n<section style=\"padding-right: 10px;padding-left: 10px;line-height: 1.5;letter-spacing: 0px;color: rgb(0, 0, 0);font-size: 18px;text-align: justify;\">\n<p style=\"text-wrap: wrap;\"><strong>2.1 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style=\"display: flex;flex-flow: row;margin: 20px 0% 10px;text-align: left;justify-content: flex-start;\">\n<section style=\"display: inline-block;vertical-align: middle;width: 15%;align-self: center;background-color: rgb(49, 116, 161);flex: 0 0 auto;height: auto;border-width: 0px;line-height: 1.4;\">\n<section style=\"text-align: justify;\">\n<p style=\"text-wrap: wrap;\"><br  \/><\/p>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: middle;width: auto;align-self: center;border-style: none;border-width: 0px;border-color: rgb(49, 116, 161) rgb(49, 116, 161) rgb(49, 116, 161) rgb(0, 137, 123);flex: 100 100 0%;height: auto;\">\n<section style=\"padding-right: 10px;padding-left: 10px;line-height: 1.5;letter-spacing: 0px;color: rgb(0, 0, 0);font-size: 18px;text-align: justify;\">\n<p style=\"text-wrap: wrap;\"><strong>2.2 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style=\"display: inline-block;width: 100%;border-width: 2px;border-style: dashed;border-color: rgb(164, 172, 181);padding: 10px;background-color: rgb(238, 249, 255);border-radius: 11.2px;overflow: hidden;\">\n<section style=\"color: rgb(0, 0, 0);\">\n<p style=\"text-wrap: 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style=\"text-wrap: wrap;\">\u4e0eDNA\u4e0d\u540c\uff0cRNA\u901a\u5e38\u662f\u5355\u94fe\u7684\uff0c\u5177\u6709\u6838\u7cd6\u800c\u975e\u8131\u6c27\u6838\u7cd6\u9aa8\u67b6\uff0c\u5e76\u4e14\u4f7f\u7528\u5c3f\u82f7\uff08U\uff09\u4ee3\u66ff\u80f8\u817a\u5627\u5576\uff08T\uff09\u4f5c\u4e3a\u78b1\u57fa\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin-top: 10px;margin-bottom: 10px;\">\n<section style=\"display: inline-block;width: 100%;border-width: 2px;border-style: dashed;border-color: rgb(164, 172, 181);padding: 10px;background-color: rgb(238, 249, 255);border-radius: 11.2px;overflow: hidden;\">\n<section style=\"color: rgb(0, 0, 0);\">\n<p style=\"text-wrap: 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style=\"margin-top: 10px;margin-bottom: 10px;\">\n<section style=\"display: inline-block;width: 100%;border-width: 2px;border-style: dashed;border-color: rgb(164, 172, 181);padding: 10px;background-color: rgb(238, 249, 255);border-radius: 11.2px;overflow: hidden;\">\n<section style=\"color: rgb(0, 0, 0);\">\n<p style=\"text-wrap: wrap;\">\u5c3d\u7ba1\u6bcf\u4e2a\u7ec6\u80de\u4e2d\u90fd\u5305\u542b\u6574\u4e2a\u57fa\u56e0\u7ec4\u7684DNA\uff0c\u4f46\u53ea\u6709\u7279\u5b9a\u57fa\u56e0\u7684\u5b50\u96c6\u4f1a\u88ab\u8868\u8fbe\u4e3aRNA\u3002\u8fd9\u4e9b\u88ab\u8f6c\u5f55\u6210RNA\u7684\u57fa\u56e0\u901a\u5e38\u7531\u975e\u7f16\u7801DNA\u533a\u57df\u6240\u8c03\u63a7\uff0c\u8fd9\u4e9b\u533a\u57df\u53ef\u4ee5\u4e0e\u5176\u4ed6\u86cb\u767d\u8d28\uff08\u5982\u8f6c\u5f55\u56e0\u5b50\uff09\u7ed3\u5408\uff0c\u4ee5\u8c03\u8282\u57fa\u56e0\u7684\u8868\u8fbe\u3002\u8fd9\u4e9b\u8c03\u63a7\u5e8f\u5217\u5305\u62ec\u542f\u52a8\u5b50\u3001\u589e\u5f3a\u5b50\u3001\u6c89\u9ed8\u5b50\u548c\u7edd\u7f18\u5b50\uff0c\u5b83\u4eec\u5171\u540c\u786e\u4fddRNA\u5728\u6b63\u786e\u7684\u65f6\u95f4\u548c\u7ec6\u80de\u4e2d\u5f97\u5230\u7cbe\u786e\u8868\u8fbe\u3002\u542f\u52a8\u5b50\u901a\u5e38\u4f4d\u4e8e\u5f85\u8f6c\u5f55\u533a\u57df\u7684\u8d77\u59cb\u4f4d\u7f6e\u9644\u8fd1\uff0c\u800c\u589e\u5f3a\u5b50\u3001\u6c89\u9ed8\u5b50\u548c\u7edd\u7f18\u5b50\u5219\u53ef\u80fd\u8fdc\u79bb\u88ab\u8c03\u63a7\u7684\u57fa\u56e0\uff0c\u4f46\u4ecd\u80fd\u6709\u6548\u5f71\u54cd\u5176\u8868\u8fbe\u3002\u6bcf\u79cd\u7ec6\u80de\u7c7b\u578b\u90fd\u6709\u81ea\u5df1\u7279\u5b9a\u7684\u4e00\u7ec4DNA\u7ed3\u5408\u86cb\u767d\uff0c\u8fd9\u4e9b\u86cb\u767d\u4e0e\u542f\u52a8\u5b50\u548c\u5176\u4ed6\u8c03\u63a7\u5e8f\u5217\u76f8\u4e92\u4f5c\u7528\uff0c\u8c03\u8282\u57fa\u56e0\u8868\u8fbe\u5e76\u51b3\u5b9a\u7ec6\u80de\u7279\u6027\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin-top: 10px;margin-bottom: 10px;\">\n<section style=\"display: inline-block;width: 100%;border-width: 2px;border-style: dashed;border-color: rgb(164, 172, 181);padding: 10px;background-color: rgb(238, 249, 255);border-radius: 11.2px;overflow: hidden;\">\n<section style=\"color: rgb(0, 0, 0);\">\n<p style=\"text-wrap: wrap;\">\u5927\u8111\u8868\u8fbe\u7684\u57fa\u56e0\u6570\u91cf\u6bd4\u8eab\u4f53\u5176\u4ed6\u4efb\u4f55\u5668\u5b98\u90fd\u591a\uff0c\u5e76\u4e14\u5728\u5927\u8111\u5185\u90e8\uff0c\u4e0d\u540c\u7684\u795e\u7ecf\u5143\u7fa4\u4f53\u8868\u8fbe\u7740\u4e0d\u540c\u7684\u57fa\u56e0\u7ec4\u5408\u3002\u7531\u542f\u52a8\u5b50\u3001\u5176\u4ed6\u8c03\u63a7\u5e8f\u5217\u53ca\u5176\u76f8\u4e92\u4f5c\u7528\u7684DNA\u7ed3\u5408\u86cb\u767d\u63a7\u5236\u7684\u9009\u62e9\u6027\u57fa\u56e0\u8868\u8fbe\uff0c\u4f7f\u5f97\u6709\u9650\u6570\u91cf\u7684\u57fa\u56e0\u80fd\u591f\u5728\u5927\u8111\u4e2d\u751f\u6210\u5927\u91cf\u4e0d\u540c\u7684\u795e\u7ecf\u5143\u7ec6\u80de\u7c7b\u578b\u548c\u590d\u6742\u7684\u795e\u7ecf\u8fde\u63a5\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin-top: 10px;margin-bottom: 10px;\">\n<section style=\"display: inline-block;width: 100%;border-width: 2px;border-style: dashed;border-color: rgb(164, 172, 181);padding: 10px;background-color: rgb(238, 249, 255);border-radius: 11.2px;overflow: hidden;\">\n<section style=\"color: rgb(0, 0, 0);\">\n<p style=\"text-wrap: wrap;\">\u867d\u7136\u57fa\u56e0\u51b3\u5b9a\u4e86\u795e\u7ecf\u7cfb\u7edf\u7684\u521d\u59cb\u53d1\u80b2\u548c\u57fa\u672c\u7279\u6027\uff0c\u4f46\u4e2a\u4f53\u7684\u7ecf\u5386\u548c\u7279\u5b9a\u795e\u7ecf\u56de\u8def\u4e2d\u7684\u6d3b\u52a8\u4e5f\u4f1a\u6539\u53d8\u57fa\u56e0\u8868\u8fbe\u3002\u901a\u8fc7\u8fd9\u79cd\u65b9\u5f0f\uff0c\u73af\u5883\u56e0\u7d20\u88ab\u6574\u5408\u5230\u795e\u7ecf\u56de\u8def\u7684\u7ed3\u6784\u548c\u529f\u80fd\u4e2d\u3002\u9057\u4f20\u5b66\u7814\u7a76\u7684\u4e3b\u8981\u76ee\u6807\u4e4b\u4e00\u662f\u9610\u660e\u5355\u4e2a\u57fa\u56e0\u5982\u4f55\u5f71\u54cd\u751f\u7269\u8fc7\u7a0b\uff0c\u57fa\u56e0\u7f51\u7edc\u5982\u4f55\u76f8\u4e92\u4f5c\u7528\uff0c\u4ee5\u53ca\u57fa\u56e0\u5982\u4f55\u4e0e\u73af\u5883\u4e92\u52a8\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-imgfileid=\"308774066\" data-ratio=\"0.6419047619047619\" data-s=\"300,640\"  data-type=\"png\" data-w=\"1050\" style=\"vertical-align: middle;width: 100%;\" src=\"http:\/\/dh.oncolab.cn\/wp-content\/uploads\/2025\/01\/wxsync-2025-01-17b2682fd9e22908466d96a1a0a3a72e.png\"  \/><\/section>\n<\/section>\n<section style=\"text-align: right;justify-content: flex-end;margin-right: 0%;margin-bottom: 10px;margin-left: 0%;display: flex;flex-flow: row;\">\n<section style=\"display: inline-block;vertical-align: top;width: 30px;border-left: 2px solid rgb(51, 122, 183);border-bottom-left-radius: 0px;border-bottom: 2px solid rgb(51, 122, 183);border-bottom-right-radius: 0px;flex: 0 0 auto;height: auto;line-height: 1;align-self: flex-start;\">\n<section style=\"text-align: justify;\">\n<p style=\"text-wrap: wrap;\"><br  \/><\/p>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: top;width: 90%;flex: 0 0 auto;height: auto;padding-left: 8px;align-self: flex-start;\">\n<section style=\"color: rgb(106, 106, 106);font-size: 15px;text-align: left;\">\n<p style=\"text-align: justify;text-wrap: wrap;\"><span style=\"color: rgb(203, 47, 21);\">\u56fe 2.2.1\uff1a<\/span><span style=\"text-align: left;\">DNA\u7684\u7ed3\u6784\u3002DNA\u7531\u53cc\u87ba\u65cb\u7ed3\u6784\u7ec4\u6210\uff0c\u56db\u79cd\u6838\u82f7\u9178\u78b1\u57fa\u2014\u2014\u817a\u560c\u5464\u3001\u80f8\u817a\u5627\u5576\u3001\u80de\u5627\u5576\u548c\u9e1f\u560c\u5464\u2014\u2014\u6cbf\u7740\u7cd6\u78f7\u9178\u9aa8\u67b6\u6392\u5217\u5728\u53cc\u94fe\u7684DNA\u87ba\u65cb\u4e0a\u3002<\/span><span style=\"text-align: left;\">&nbsp;<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-imgfileid=\"308774063\" data-ratio=\"0.7974193548387096\" data-s=\"300,640\"  data-type=\"png\" data-w=\"775\" style=\"vertical-align: middle;width: 100%;\" src=\"http:\/\/dh.oncolab.cn\/wp-content\/uploads\/2025\/01\/wxsync-2025-01-8bfa1d3552cb543ec0671168572ba913.png\"  \/><\/section>\n<\/section>\n<section style=\"text-align: right;justify-content: flex-end;margin-right: 0%;margin-bottom: 10px;margin-left: 0%;display: flex;flex-flow: row;\">\n<section style=\"display: inline-block;vertical-align: top;width: 30px;border-left: 2px solid rgb(51, 122, 183);border-bottom-left-radius: 0px;border-bottom: 2px solid rgb(51, 122, 183);border-bottom-right-radius: 0px;flex: 0 0 auto;height: auto;line-height: 1;align-self: flex-start;\">\n<section style=\"text-align: justify;\">\n<p style=\"text-wrap: wrap;\"><br  \/><\/p>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: top;width: 90%;flex: 0 0 auto;height: auto;padding-left: 8px;align-self: flex-start;\">\n<section style=\"color: rgb(106, 106, 106);font-size: 15px;text-align: left;\">\n<p style=\"text-align: justify;text-wrap: wrap;\"><span style=\"color: rgb(203, 47, 21);\">\u56fe 2.2.2\uff1a<\/span><span style=\"text-align: left;\">\u57fa\u56e0\u7ed3\u6784\u4e0e\u8868\u8fbe\u3002A. \u57fa\u56e0\u7531\u7f16\u7801\u533a\uff08\u5916\u663e\u5b50\uff09\u548c\u975e\u7f16\u7801\u533a\uff08\u5185\u542b\u5b50\uff09\u7ec4\u6210\uff0c\u5185\u542b\u5b50\u5c06\u5916\u663e\u5b50\u5206\u9694\u5f00\u3002\u57fa\u56e0\u7684\u8f6c\u5f55\u53d7\u975e\u7f16\u7801\u533a\u7684\u8c03\u63a7\uff0c\u4f8b\u5982\u542f\u52a8\u5b50\u548c\u589e\u5f3a\u5b50\uff0c\u8fd9\u4e9b\u901a\u5e38\u4f4d\u4e8e\u57fa\u56e0\u7684\u8d77\u59cb\u4f4d\u7f6e\u9644\u8fd1\u3002B. \u8f6c\u5f55\u8fc7\u7a0b\u751f\u6210\u5305\u542b\u5916\u663e\u5b50\u548c\u5185\u542b\u5b50\u7684\u521d\u7ea7\u5355\u94feRNA\u8f6c\u5f55\u672c\u3002C. \u526a\u63a5\u8fc7\u7a0b\u5c06\u5185\u542b\u5b50\u4ece\u672a\u6210\u719f\u7684\u8f6c\u5f55\u672c\u4e2d\u79fb\u9664\uff0c\u5e76\u5c06\u5916\u663e\u5b50\u8fde\u63a5\u5f62\u6210\u6210\u719f\u7684mRNA\uff0c\u540e\u8005\u968f\u540e\u4ece\u7ec6\u80de\u6838\u4e2d\u8f93\u51fa\u3002D. \u6210\u719f\u7684mRNA\u5728\u7ffb\u8bd1\u8fc7\u7a0b\u4e2d\u751f\u6210\u86cb\u767d\u8d28\u4ea7\u7269\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"color: rgb(203, 47, 21);line-height: 1.5;\">\n<p style=\"text-wrap: wrap;\"><strong>2.2.1&nbsp;<\/strong><strong>\u57fa\u56e0\u5728\u67d3\u8272\u4f53\u4e0a\u7684\u6392\u5217<\/strong><\/p>\n<\/section>\n<section style=\"margin-top: 10px;margin-bottom: 10px;\">\n<section style=\"display: inline-block;width: 100%;border-width: 2px;border-style: dashed;border-color: rgb(164, 172, 181);padding: 10px;background-color: rgb(238, 249, 255);border-radius: 11.2px;overflow: hidden;\">\n<section style=\"color: rgb(0, 0, 0);\">\n<p style=\"text-wrap: wrap;\">\u7ec6\u80de\u4e2d\u7684\u57fa\u56e0\u6709\u5e8f\u5730\u6392\u5217\u5728\u79f0\u4e3a\u67d3\u8272\u4f53\u7684\u957f\u800c\u7ebf\u6027\u7684DNA\u94fe\u4e0a\u3002\u4eba\u7c7b\u57fa\u56e0\u7ec4\u4e2d\u7684\u6bcf\u4e2a\u57fa\u56e0\u90fd\u4f4d\u4e8e\u7279\u5b9a\u67d3\u8272\u4f53\u4e0a\u7684\u56fa\u5b9a\u4f4d\u7f6e\uff0c\u79f0\u4e3a\u57fa\u56e0\u5ea7\uff08locus\uff09\u3002\u8fd9\u4e2a\u9057\u4f20\u201c\u5730\u5740\u201d\u6709\u52a9\u4e8e\u5c06\u751f\u7269\u5b66\u7279\u5f81\u4e0e\u57fa\u56e0\u7684\u4f5c\u7528\u8054\u7cfb\u8d77\u6765\u3002\u5927\u591a\u6570\u591a\u7ec6\u80de\u52a8\u7269\uff08\u5305\u62ec\u8815\u866b\u3001\u679c\u8747\u3001\u5c0f\u9f20\u548c\u4eba\u7c7b\uff09\u90fd\u662f\u4e8c\u500d\u4f53\uff0c\u8fd9\u610f\u5473\u7740\u6bcf\u4e2a\u4f53\u7ec6\u80de\u643a\u5e26\u4e24\u5957\u5b8c\u6574\u7684\u67d3\u8272\u4f53\uff0c\u4e00\u5957\u6765\u81ea\u6bcd\u4eb2\uff0c\u53e6\u4e00\u5957\u6765\u81ea\u7236\u4eb2\u3002\u4eba\u7c7b\u57fa\u56e0\u7ec4\u5927\u7ea6\u5305\u542b2\u4e07\u4e2a\u57fa\u56e0\uff0c\u4f46\u8fd9\u4e9b\u57fa\u56e0\u5206\u5e03\u572846\u6761\u67d3\u8272\u4f53\u4e0a\uff1a22\u5bf9\u5e38\u67d3\u8272\u4f53\uff08\u5728\u7537\u6027\u548c\u5973\u6027\u4e2d\u90fd\u5b58\u5728\uff09\u548c\u4e24\u6761\u6027\u67d3\u8272\u4f53\uff08\u5973\u6027\u6709\u4e24\u6761X\u67d3\u8272\u4f53\uff0c\u7537\u6027\u6709\u4e00\u6761X\u67d3\u8272\u4f53\u548c\u4e00\u6761Y\u67d3\u8272\u4f53\uff0c\u89c1<span style=\"color: rgb(203, 47, 21);\">\u56fe2.2.3<\/span>\uff09\u3002\u6bcf\u4f4d\u7236\u6bcd\u90fd\u4e3a\u4e8c\u500d\u4f53\u540e\u4ee3\u63d0\u4f9b\u6bcf\u5bf9\u5e38\u67d3\u8272\u4f53\u4e2d\u7684\u4e00\u6761\u3002\u6b64\u5916\uff0c\u6bcf\u4f4d\u7236\u6bcd\u8fd8\u4e3a\u5973\u6027\uff08XX\uff09\u540e\u4ee3\u63d0\u4f9b\u4e00\u6761X\u67d3\u8272\u4f53\uff0c\u800cXY\u67d3\u8272\u4f53\u7684\u7537\u6027\u4ece\u6bcd\u4eb2\u7ee7\u627f\u4e00\u6761X\u67d3\u8272\u4f53\uff0c\u4ece\u7236\u4eb2\u7ee7\u627f\u4e00\u6761Y\u67d3\u8272\u4f53\u3002<\/p>\n<p style=\"text-wrap: wrap;\">\u4f34\u6027\u9057\u4f20\u7531\u6258\u9a6c\u65af\u00b7\u6469\u5c14\u6839\u4e8e1910\u5e74\u901a\u8fc7\u5bf9\u679c\u8747\u7684\u7814\u7a76\u9996\u6b21\u53d1\u73b0\u3002\u8fd9\u79cd\u4e0eX\u67d3\u8272\u4f53\u76f8\u5173\u7684\u4f34\u6027\u9057\u4f20\u6a21\u5f0f\u5728\u4eba\u7c7b\u9057\u4f20\u5b66\u4e2d\u5177\u6709\u91cd\u8981\u610f\u4e49\u3002\u4f8b\u5982\uff0c\u4e00\u4e9bX\u8fde\u9501\u9057\u4f20\u75c5\u901a\u5e38\u4ec5\u5728\u7537\u6027\u4e2d\u8868\u73b0\u51fa\u6765\uff0c\u5c3d\u7ba1\u8fd9\u4e9b\u75be\u75c5\u662f\u4ece\u6bcd\u4eb2\u90a3\u91cc\u9057\u4f20\u7684\uff0c\u5e76\u901a\u8fc7\u513f\u5b50\u4f20\u9012\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-imgfileid=\"308774065\" data-ratio=\"0.72920892494929\" data-s=\"300,640\"  data-type=\"png\" data-w=\"986\" style=\"vertical-align: middle;width: 100%;\" src=\"http:\/\/dh.oncolab.cn\/wp-content\/uploads\/2025\/01\/wxsync-2025-01-06a61d7d0f4232d05156db9d73d54319.png\"  \/><\/section>\n<\/section>\n<section style=\"text-align: right;justify-content: flex-end;margin-right: 0%;margin-bottom: 10px;margin-left: 0%;display: flex;flex-flow: row;\">\n<section style=\"display: inline-block;vertical-align: top;width: 30px;border-left: 2px solid rgb(51, 122, 183);border-bottom-left-radius: 0px;border-bottom: 2px solid rgb(51, 122, 183);border-bottom-right-radius: 0px;flex: 0 0 auto;height: auto;line-height: 1;align-self: flex-start;\">\n<section style=\"text-align: justify;\">\n<p style=\"text-wrap: wrap;\"><br  \/><\/p>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: top;width: 90%;flex: 0 0 auto;height: auto;padding-left: 8px;align-self: flex-start;\">\n<section style=\"color: rgb(106, 106, 106);font-size: 15px;text-align: left;\">\n<p style=\"text-align: justify;text-wrap: wrap;\"><span style=\"color: rgb(203, 47, 21);\">\u56fe 2.2.3\uff1a<\/span><span style=\"text-align: left;\">\u4e2d\u671f\u9636\u6bb5\u7684\u4eba\u7c7b\u67d3\u8272\u4f53\u56fe\u89e3\uff0c\u5c55\u793a\u4e86\u6bcf\u6761\u67d3\u8272\u4f53\u7684\u72ec\u7279\u5f62\u6001\u3002\u67d3\u8272\u4f53\u7684\u7279\u5b9a\u5927\u5c0f\u4ee5\u53ca\u5176\u4e0a\u7684\u660e\u6697\u6761\u5e26\u56fe\u6848\uff0c\u4f7f\u5f97\u6bcf\u6761\u67d3\u8272\u4f53\u53ef\u4ee5\u5f7c\u6b64\u533a\u5206\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin-top: 10px;margin-bottom: 10px;\">\n<section style=\"display: inline-block;width: 100%;border-width: 2px;border-style: dashed;border-color: rgb(164, 172, 181);padding: 10px;background-color: rgb(238, 249, 255);border-radius: 11.2px;overflow: hidden;\">\n<section style=\"color: rgb(0, 0, 0);\">\n<p style=\"text-wrap: wrap;\">\u9664\u4e86\u67d3\u8272\u4f53\u4e0a\u7684\u57fa\u56e0\u5916\uff0c\u751f\u7269\u4f53\u8fd8\u6709\u5c11\u91cf\u57fa\u56e0\u901a\u8fc7\u7ebf\u7c92\u4f53\u9057\u4f20\u3002\u7ebf\u7c92\u4f53\u662f\u8d1f\u8d23\u7ec6\u80de\u4ee3\u8c22\u8fc7\u7a0b\u7684\u7ec6\u80de\u5668\uff0c\u5b58\u5728\u4e8e\u7ec6\u80de\u8d28\u4e2d\u3002\u6240\u6709\u5b69\u5b50\u7684\u7ebf\u7c92\u4f53\u90fd\u6765\u81ea\u6bcd\u4eb2\u7684\u5375\u7ec6\u80de\uff0c\u56e0\u6b64\u7ebf\u7c92\u4f53DNA\u662f\u7531\u6bcd\u4eb2\u4f20\u7ed9\u540e\u4ee3\u7684\u3002\u4e00\u4e9b\u4eba\u7c7b\u75be\u75c5\uff0c\u5305\u62ec\u67d0\u4e9b\u795e\u7ecf\u808c\u8089\u9000\u884c\u6027\u75be\u75c5\u3001\u667a\u529b\u969c\u788d\u7684\u67d0\u4e9b\u7c7b\u578b\u4ee5\u53ca\u67d0\u4e9b\u8033\u804b\u7684\u5f62\u5f0f\uff0c\u662f\u7531\u7ebf\u7c92\u4f53DNA\u4e2d\u7684\u7a81\u53d8\u5f15\u8d77\u7684\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"display: flex;flex-flow: row;margin: 20px 0% 10px;text-align: left;justify-content: flex-start;\">\n<section style=\"display: inline-block;vertical-align: middle;width: 15%;align-self: center;background-color: rgb(49, 116, 161);flex: 0 0 auto;height: auto;border-width: 0px;line-height: 1.4;\">\n<section style=\"text-align: justify;\">\n<p style=\"text-wrap: wrap;\"><br  \/><\/p>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: middle;width: auto;align-self: center;border-style: none;border-width: 0px;border-color: rgb(49, 116, 161) rgb(49, 116, 161) rgb(49, 116, 161) rgb(0, 137, 123);flex: 100 100 0%;height: auto;\">\n<section style=\"padding-right: 10px;padding-left: 10px;line-height: 1.5;letter-spacing: 0px;color: rgb(0, 0, 0);font-size: 18px;text-align: justify;\">\n<p style=\"text-wrap: wrap;\"><strong>2.3 \u57fa\u56e0\u578b\u4e0e\u8868\u578b\u4e4b\u95f4\u7684\u5173\u7cfb\u901a\u5e38\u975e\u5e38\u590d\u6742<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin-top: 10px;margin-bottom: 10px;\">\n<section style=\"display: inline-block;width: 100%;border-width: 2px;border-style: dashed;border-color: rgb(164, 172, 181);padding: 10px;background-color: rgb(238, 249, 255);border-radius: 11.2px;overflow: hidden;\">\n<section style=\"color: rgb(0, 0, 0);\">\n<p style=\"text-wrap: wrap;\">\u4e2a\u4f53\u4e2d\u67d0\u4e2a\u5e38\u67d3\u8272\u4f53\u57fa\u56e0\u7684\u4e24\u4e2a\u526f\u672c\u79f0\u4e3a\u7b49\u4f4d\u57fa\u56e0\u3002\u5982\u679c\u8fd9\u4e24\u4e2a\u7b49\u4f4d\u57fa\u56e0\u76f8\u540c\uff0c\u4e2a\u4f53\u5728\u8be5\u57fa\u56e0\u4f4d\u70b9\u4e0a\u88ab\u79f0\u4e3a\u7eaf\u5408\u5b50\uff1b\u5982\u679c\u4e24\u4e2a\u7b49\u4f4d\u57fa\u56e0\u7531\u4e8e\u7a81\u53d8\u800c\u4e0d\u540c\uff0c\u5219\u79f0\u4e3a\u6742\u5408\u5b50\u3002\u7537\u6027\u5728X\u67d3\u8272\u4f53\u4e0a\u7684\u57fa\u56e0\u662f\u534a\u5408\u5b50\uff0c\u56e0\u4e3a\u4ed6\u4eec\u53ea\u6709\u4e00\u6761X\u67d3\u8272\u4f53\u3002\u4e00\u4e2a\u7fa4\u4f53\u4e2d\u53ef\u4ee5\u5b58\u5728\u591a\u4e2a\u7b49\u4f4d\u57fa\u56e0\uff1b\u4f8b\u5982\uff0c\u63a7\u5236\u4eba\u7c7b\u773c\u775b\u989c\u8272\u7684OCA2\u57fa\u56e0\uff0c\u53ef\u80fd\u6709\u4e0d\u540c\u7684\u7b49\u4f4d\u57fa\u56e0\uff0c\u7f16\u7801\u84dd\u8272\u3001\u7eff\u8272\u3001\u6d45\u8910\u8272\u6216\u68d5\u8272\u7684\u773c\u775b\u989c\u8272\u3002\u56e0\u6b64\uff0c\u533a\u5206\u751f\u7269\u4f53\u7684\u57fa\u56e0\u578b\uff08\u9057\u4f20\u6784\u6210\uff09\u548c\u8868\u578b\uff08\u5916\u5728\u8868\u73b0\uff09\u662f\u975e\u5e38\u91cd\u8981\u7684\u3002\u5e7f\u4e49\u4e0a\uff0c\u57fa\u56e0\u578b\u6307\u4e2a\u4f53\u57fa\u56e0\u7ec4\u4e2d\u6240\u6709\u7b49\u4f4d\u57fa\u56e0\u7684\u7ec4\u5408\uff1b\u72ed\u4e49\u4e0a\uff0c\u5b83\u6307\u7684\u662f\u67d0\u4e2a\u7279\u5b9a\u57fa\u56e0\u7684\u7b49\u4f4d\u57fa\u56e0\u3002\u800c\u8868\u578b\u662f\u6574\u4e2a\u751f\u7269\u4f53\u7684\u8868\u73b0\uff0c\u662f\u57fa\u56e0\u578b\u5728\u7279\u5b9a\u73af\u5883\u4e0b\u8868\u8fbe\u7684\u7ed3\u679c\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin-top: 10px;margin-bottom: 10px;\">\n<section style=\"display: inline-block;width: 100%;border-width: 2px;border-style: dashed;border-color: rgb(164, 172, 181);padding: 10px;background-color: rgb(238, 249, 255);border-radius: 11.2px;overflow: hidden;\">\n<section style=\"color: rgb(0, 0, 0);\">\n<p style=\"text-wrap: wrap;\">\u5982\u679c\u4e00\u4e2a\u7a81\u53d8\u7684\u8868\u578b\u53ea\u6709\u5728\u8be5\u57fa\u56e0\u7684\u4e24\u4e2a\u7b49\u4f4d\u57fa\u56e0\u90fd\u53d1\u751f\u7a81\u53d8\u65f6\u624d\u8868\u73b0\u51fa\u6765\uff0c\u90a3\u4e48\u8fd9\u79cd\u8868\u578b\u88ab\u79f0\u4e3a\u9690\u6027\u8868\u578b\u3002\u8fd9\u901a\u5e38\u53d1\u751f\u5728\u4e2a\u4f53\u662f\u7a81\u53d8\u7b49\u4f4d\u57fa\u56e0\u7684\u7eaf\u5408\u5b50\uff0c\u6216\u662f\u6240\u8c13\u7684\u590d\u5408\u6742\u5408\u5b50\uff0c\u5373\u5728\u4e24\u6761\u67d3\u8272\u4f53\u7684\u76f8\u5e94\u57fa\u56e0\u4e2d\u5404\u643a\u5e26\u4e00\u4e2a\u4e0d\u540c\u7684\u6709\u5bb3\u7b49\u4f4d\u57fa\u56e0\u3002\u9690\u6027\u7a81\u53d8\u901a\u5e38\u662f\u7531\u529f\u80fd\u6027\u86cb\u767d\u7684\u4e27\u5931\u6216\u51cf\u5c11\u5f15\u8d77\u7684\u3002\u5728\u4eba\u7c7b\u548c\u5b9e\u9a8c\u52a8\u7269\u4e2d\uff0c\u7a81\u53d8\u6027\u72b6\u7684\u9690\u6027\u9057\u4f20\u73b0\u8c61\u975e\u5e38\u5e38\u89c1\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin-top: 10px;margin-bottom: 10px;\">\n<section style=\"display: inline-block;width: 100%;border-width: 2px;border-style: dashed;border-color: rgb(164, 172, 181);padding: 10px;background-color: rgb(238, 249, 255);border-radius: 11.2px;overflow: hidden;\">\n<section style=\"color: rgb(0, 0, 0);\">\n<p style=\"text-wrap: wrap;\">\u5982\u679c\u7a81\u53d8\u7684\u8868\u578b\u7531\u4e00\u4e2a\u7a81\u53d8\u7b49\u4f4d\u57fa\u56e0\u548c\u4e00\u4e2a\u91ce\u751f\u578b\u7b49\u4f4d\u57fa\u56e0\u7684\u7ec4\u5408\u4ea7\u751f\uff0c\u90a3\u4e48\u8fd9\u79cd\u8868\u578b\u548c\u7a81\u53d8\u7b49\u4f4d\u57fa\u56e0\u5c31\u88ab\u8ba4\u4e3a\u662f\u663e\u6027\u8868\u578b\u548c\u663e\u6027\u7a81\u53d8\u3002\u4e00\u4e9b\u663e\u6027\u7a81\u53d8\u662f\u56e0\u4e3a50%\u7684\u57fa\u56e0\u4ea7\u7269\u4e0d\u8db3\u4ee5\u7ef4\u6301\u6b63\u5e38\u7684\u8868\u578b\uff08\u5355\u500d\u4f53\u4e0d\u8db3\uff09\u3002\u5176\u4ed6\u663e\u6027\u7a81\u53d8\u53ef\u80fd\u5bfc\u81f4\u5f02\u5e38\u86cb\u767d\u7684\u4ea7\u751f\uff0c\u6216\u8005\u5f15\u8d77\u91ce\u751f\u578b\u57fa\u56e0\u4ea7\u7269\u5728\u4e0d\u9002\u5f53\u7684\u65f6\u95f4\u6216\u5730\u70b9\u8868\u8fbe\uff1b\u5982\u679c\u8fd9\u79cd\u5f02\u5e38\u8868\u8fbe\u5bf9\u6297\u6b63\u5e38\u86cb\u767d\u7684\u529f\u80fd\uff0c\u5b83\u5c31\u88ab\u79f0\u4e3a\u663e\u6027\u8d1f\u6548\u5e94\u7a81\u53d8\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin-top: 10px;margin-bottom: 10px;\">\n<section style=\"display: inline-block;width: 100%;border-width: 2px;border-style: dashed;border-color: rgb(164, 172, 181);padding: 10px;background-color: rgb(238, 249, 255);border-radius: 11.2px;overflow: hidden;\">\n<section style=\"color: rgb(0, 0, 0);\">\n<p style=\"text-wrap: wrap;\">\u5f53\u8003\u8651\u4e00\u4e2a\u57fa\u56e0\u7684\u6b63\u5e38\uff08\u91ce\u751f\u578b\uff09\u7b49\u4f4d\u57fa\u56e0\u4e0e\u7a81\u53d8\u7b49\u4f4d\u57fa\u56e0\u5171\u5b58\u7684\u540e\u679c\u65f6\uff0c\u57fa\u56e0\u578b\u4e0e\u8868\u578b\u4e4b\u95f4\u7684\u533a\u522b\u53d8\u5f97\u5c24\u4e3a\u91cd\u8981\u3002\u8fd1\u5e74\u6765\uff0c\u5728\u81ea\u95ed\u75c7\u548c\u766b\u75eb\u7b49\u795e\u7ecf\u53d1\u80b2\u969c\u788d\u7684\u57fa\u56e0\u7814\u7a76\u4e2d\uff0c\u53d1\u73b0\u4eba\u7c7b\u57fa\u56e0\u7ec4\u5bf9\u5355\u500d\u4f53\u4e0d\u8db3\u7684\u654f\u611f\u6027\u6bd4\u4e4b\u524d\u8ba4\u4e3a\u7684\u66f4\u9ad8\u3002\u7136\u800c\uff0c\u5c3d\u7ba1\u4e00\u4e2a\u57fa\u56e0\u7684\u4e24\u4e2a\u526f\u672c\u5b8c\u5168\u5931\u6d3b\u901a\u5e38\u4f1a\u4ea7\u751f\u53ef\u9884\u6d4b\u7684\u6548\u679c\uff0c\u5355\u500d\u4f53\u4e0d\u8db3\u7684\u4e25\u91cd\u7a0b\u5ea6\u548c\u8868\u73b0\u5f62\u5f0f\u5728\u4e0d\u540c\u4e2a\u4f53\u4e4b\u95f4\u53ef\u80fd\u6709\u5f88\u5927\u5dee\u5f02\uff0c\u8fd9\u79cd\u73b0\u8c61\u88ab\u79f0\u4e3a\u53ef\u53d8\u5916\u663e\u7387\u6216\u90e8\u5206\u3001\u4e0d\u5b8c\u5168\u5916\u663e\u7387\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin-top: 10px;margin-bottom: 10px;\">\n<section style=\"display: inline-block;width: 100%;border-width: 2px;border-style: dashed;border-color: rgb(164, 172, 181);padding: 10px;background-color: rgb(238, 249, 255);border-radius: 11.2px;overflow: hidden;\">\n<section style=\"color: rgb(0, 0, 0);\">\n<p style=\"text-wrap: wrap;\">\u9057\u4f20\u53d8\u5f02\u5bf9\u4eba\u7c7b\u53d1\u80b2\u3001\u7ec6\u80de\u529f\u80fd\u6216\u884c\u4e3a\u7684\u5f71\u54cd\u662f\u4e00\u4e2a\u4ece\u5e38\u89c1\u7b49\u4f4d\u57fa\u56e0\uff08\u4e5f\u79f0\u4e3a\u591a\u6001\u6027\uff09\u5230\u7f55\u89c1\u53d8\u5f02\u7684\u8fde\u7eed\u4f53\u3002\u901a\u5e38\uff0c\u5e38\u89c1\u7684\u7b49\u4f4d\u57fa\u56e0\u5bf9\u751f\u7269\u5b66\u548c\u884c\u4e3a\u7684\u4e2a\u4f53\u5f71\u54cd\u8f83\u5c0f\uff0c\u800c\u7f55\u89c1\u53d8\u5f02\u53ef\u80fd\u5177\u6709\u8f83\u5927\u7684\u751f\u7269\u5b66\u6548\u5e94\uff08\u89c1<span style=\"color: rgb(82, 120, 56);\">Box 2.1<\/span>\uff09\u3002\u5c3d\u7ba1\u8fd9\u4e9b\u5206\u7c7b\u5177\u6709\u6982\u62ec\u6027\uff0c\u4f46\u5728\u4e00\u4e9b\u91cd\u8981\u6848\u4f8b\u4e2d\uff0c\u5e38\u89c1\u7684\u591a\u6001\u6027\u4e5f\u53ef\u80fd\u663e\u8457\u589e\u52a0\u75be\u75c5\u98ce\u9669\u3002\u4f8b\u5982\uff0cAPOE\u57fa\u56e0\u7684\u4e00\u79cd\u5e38\u89c1\u53d8\u5f02\u572816%\u7684\u4eba\u7fa4\u4e2d\u5b58\u5728\uff0c\u53ef\u5c06\u665a\u53d1\u6027\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u7684\u98ce\u9669\u589e\u52a0\u56db\u500d\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"transform-origin: left top;\">\n<section style=\"text-align: center;justify-content: center;display: flex;flex-flow: row;margin-top: 10px;margin-bottom: 4px;\">\n<section style=\"display: inline-block;vertical-align: middle;width: auto;min-width: 5%;flex: 0 0 auto;height: auto;align-self: center;\">\n<section style=\"display: flex;width: 100%;flex-flow: column;\">\n<section style=\"transform: rotateZ(19deg) rotateX(31deg) rotateY(326deg);transform-origin: center center;z-index: 1;\">\n<section style=\"justify-content: center;display: flex;flex-flow: row;\">\n<section style=\"display: inline-block;width: auto;vertical-align: top;align-self: flex-start;flex: 0 0 auto;min-width: 5%;height: auto;\">\n<section style=\"z-index: auto;\">\n<section style=\"text-align: left;justify-content: flex-start;display: flex;flex-flow: row;\">\n<section style=\"display: inline-block;width: auto;vertical-align: middle;align-self: center;flex: 0 0 auto;min-width: 5%;height: auto;padding-right: 5px;padding-left: 5px;border-radius: 6px;overflow: hidden;background-color: rgb(214, 238, 214);\">\n<section style=\"text-align: center;\">\n<section style=\"font-size: 20px;color: rgb(0, 0, 0);\">\n<p>Box 2.1 (\u7a81\u53d8\uff1a\u9057\u4f20\u591a\u6837\u6027\u7684\u8d77\u6e90)<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: middle;width: auto;align-self: center;flex: 100 100 0%;height: auto;\">\n<section style=\"margin-top: 10px;margin-bottom: 10px;\">\n<section style=\"background-color: rgb(214, 238, 214);height: 2px;\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"transform-origin: left top;\">\n<section style=\"text-align: center;justify-content: center;display: flex;flex-flow: row;margin-top: 10px;margin-bottom: 4px;\">\n<section style=\"display: inline-block;vertical-align: middle;width: auto;min-width: 5%;flex: 0 0 auto;height: auto;align-self: center;\">\n<section style=\"justify-content: center;display: flex;flex-flow: row;margin-bottom: 10px;\">\n<section style=\"display: inline-block;width: 100%;vertical-align: top;align-self: flex-start;flex: 0 0 auto;height: auto;background-color: rgb(241, 248, 240);padding: 21px;line-height: 1.5;\">\n<section style=\"text-align: justify;\">\n<p style=\"text-wrap: wrap;\">\u5c3d\u7ba1DNA\u590d\u5236\u901a\u5e38\u5177\u6709\u5f88\u9ad8\u7684\u51c6\u786e\u6027\uff0c\u4f46\u81ea\u53d1\u7684\u9519\u8bef\u2014\u2014\u79f0\u4e3a\u7a81\u53d8\u2014\u2014\u4ecd\u7136\u4f1a\u53d1\u751f\u3002\u7a81\u53d8\u53ef\u80fd\u7531\u4e8e\u560c\u5464\u548c\u5627\u5576\u78b1\u57fa\u7684\u635f\u4f24\u3001DNA\u590d\u5236\u8fc7\u7a0b\u4e2d\u7684\u9519\u8bef\u6216\u51cf\u6570\u5206\u88c2\u4e2d\u7684\u91cd\u7ec4\u6240\u5f15\u53d1\u3002<\/p>\n<p style=\"text-wrap: wrap;\">\u5728\u7f16\u7801\u533a\u5185\uff0c\u5355\u4e2aDNA\u78b1\u57fa\u7684\u53d8\u5316\uff08\u4e5f\u79f0\u4e3a\u70b9\u7a81\u53d8\uff09\u53ef\u5206\u4e3a\u4e94\u5927\u7c7b\uff1a<\/p>\n<p style=\"text-wrap: wrap;\">1.<strong>\u65e0\u58f0\u7a81\u53d8<\/strong>(silent mutation)\uff1a\u6539\u53d8\u4e86\u78b1\u57fa\uff0c\u4f46\u4e0d\u4f1a\u5bfc\u81f4\u86cb\u767d\u8d28\u7684\u529f\u80fd\u53d1\u751f\u660e\u663e\u53d8\u5316\u3002<\/p>\n<p style=\"text-wrap: wrap;\">2.<strong>\u9519\u4e49\u7a81\u53d8<\/strong>(missense mutation)\uff1a\u5bfc\u81f4\u86cb\u767d\u8d28\u4e2d\u7684\u4e00\u4e2a\u6c28\u57fa\u9178\u88ab\u53e6\u4e00\u4e2a\u53d6\u4ee3\u3002\u968f\u7740\u4fe1\u606f\u5b66\u6280\u672f\u548c\u5b9e\u9a8c\u624b\u6bb5\u7684\u53d1\u5c55\uff0c\u8fd9\u4e9b\u7a81\u53d8\u53ef\u4ee5\u8fdb\u4e00\u6b65\u7ec6\u5206\u4e3a\u4e24\u7c7b\uff1a\u635f\u5bb3\u86cb\u767d\u8d28\u529f\u80fd\u7684\u7a81\u53d8\u548c\u5bf9\u529f\u80fd\u65e0\u660e\u663e\u5f71\u54cd\u7684\u7a81\u53d8\u3002<\/p>\n<p style=\"text-wrap: wrap;\">3.<strong>\u65e0\u4e49\u7a81\u53d8<\/strong>(nonsense mutation)\uff1a\u5c06\u7f16\u7801\u7279\u5b9a\u6c28\u57fa\u9178\u7684\u5bc6\u7801\u5b50\uff08\u4e09\u8054\u6838\u82f7\u9178\uff09\u8f6c\u53d8\u4e3a\u7ec8\u6b62\u5bc6\u7801\u5b50\uff0c\u5bfc\u81f4\u86cb\u767d\u8d28\u4ea7\u7269\u7f29\u77ed\uff08\u622a\u77ed\uff09\u3002<\/p>\n<p style=\"text-wrap: wrap;\">4.<strong>\u526a\u63a5\u4f4d\u70b9\u7a81\u53d8<\/strong>(canonical splice site mutation)\uff1a\u6539\u53d8\u4e86\u5916\u663e\u5b50\/\u5185\u542b\u5b50\u8fb9\u754c\u7684\u6838\u82f7\u9178\uff0c\u5f71\u54cdRNA\u526a\u63a5\u3002<\/p>\n<p style=\"text-wrap: wrap;\">5.<strong>\u6846\u79fb\u7a81\u53d8<\/strong>(frameshift mutation)\uff1a\u7531\u4e8e\u63d2\u5165\u6216\u7f3a\u5931\u5c0f\u7247\u6bb5\u6838\u82f7\u9178\uff0c\u5bfc\u81f4\u9605\u8bfb\u6846\u7684\u6539\u53d8\uff0c\u4ece\u800c\u4ea7\u751f\u622a\u77ed\u6216\u5f02\u5e38\u7684\u86cb\u767d\u8d28\u3002\u73b0\u6709\u6587\u732e\u4e2d\uff0c\u540e\u56db\u7c7b\u7a81\u53d8\uff08\u5305\u62ec\u7834\u574f\u6027\u9519\u4e49\u7a81\u53d8\uff09\u901a\u5e38\u88ab\u79f0\u4e3a\u53ef\u80fd\u7834\u574f\u57fa\u56e0\u7684\u7a81\u53d8\u3002<\/p>\n<p style=\"text-wrap: wrap;\">\u5728\u5b9e\u9a8c\u9057\u4f20\u5b66\u7814\u7a76\u4e2d\uff0c\u5316\u5b66\u8bf1\u53d8\u5242\u6216\u7535\u79bb\u8f90\u5c04\u7684\u66b4\u9732\u4f1a\u663e\u8457\u589e\u52a0\u7a81\u53d8\u9891\u7387\u3002\u5316\u5b66\u8bf1\u53d8\u5242\u503e\u5411\u4e8e\u8bf1\u5bfc\u70b9\u7a81\u53d8\uff0c\u6d89\u53ca\u5355\u4e2aDNA\u78b1\u57fa\u5bf9\u7684\u53d8\u5316\u6216\u51e0\u4e2a\u78b1\u57fa\u5bf9\u7684\u7f3a\u5931\u3002\u7535\u79bb\u8f90\u5c04\u5219\u53ef\u80fd\u5bfc\u81f4\u5927\u8303\u56f4\u7684\u63d2\u5165\u3001\u7f3a\u5931\u6216\u6613\u4f4d\u3002<\/p>\n<p style=\"text-wrap: wrap;\">\u5728\u4eba\u7c7b\u4e2d\uff0c\u70b9\u7a81\u53d8\u4ee5\u8f83\u4f4e\u7684\u81ea\u53d1\u7387\u53d1\u751f\u4e8e\u5375\u5b50\u548c\u7cbe\u5b50\u4e2d\uff0c\u5bfc\u81f4\u5b50\u4ee3\u51fa\u73b0\u7a81\u53d8\uff0c\u800c\u7236\u6bcd\u5219\u6ca1\u6709\uff0c\u8fd9\u79cd\u7a81\u53d8\u88ab\u79f0\u4e3a\u65b0\u751f\u7a81\u53d8\u3002\u6bcf\u4ee3\u4eba\u4e2d\uff0c\u6574\u4e2a\u57fa\u56e0\u7ec4\uff08\u7ea630\u4ebf\u78b1\u57fa\u5bf9\uff09\u4f1a\u53d1\u751f70\u81f390\u4e2a\u5355\u78b1\u57fa\u53d8\u5316\uff0c\u5176\u4e2d\u4e00\u4e2a\u78b1\u57fa\u5bf9\u5e73\u5747\u4f1a\u5bfc\u81f4\u4e00\u4e2a\u7f16\u7801\u86cb\u767d\u8d28\u7684\u57fa\u56e0\u53d1\u751f\u9519\u4e49\u7a81\u53d8\u6216\u65e0\u4e49\u7a81\u53d8\u3002\u7236\u4eb2\u5e74\u9f84\u8d8a\u5927\uff0c\u5b50\u4ee3\u65b0\u751f\u7a81\u53d8\u7684\u6570\u91cf\u8d8a\u591a\uff0c\u800c\u6bcd\u4eb2\u5e74\u9f84\u8f83\u5927\u65f6\uff0c\u5b50\u4ee3\u51fa\u73b0\u67d3\u8272\u4f53\u5f02\u5e38\u7684\u6982\u7387\u66f4\u9ad8\u3002<\/p>\n<p style=\"text-wrap: wrap;\">\u81ea2001\u5e74\u4eba\u7c7b\u57fa\u56e0\u7ec4\u6d4b\u5e8f\u4ee5\u6765\uff0c\u968f\u7740\u68c0\u6d4b\u57fa\u56e0\u53d8\u5f02\u7684\u9ad8\u5206\u8fa8\u7387\u65b9\u6cd5\u4e0d\u65ad\u63d0\u5347\uff0c\u73b0\u5728\u6211\u4eec\u77e5\u9053\uff0c\u70b9\u7a81\u53d8\u5e76\u4e0d\u662f\u4eba\u7c7b\u4e4b\u95f4\u552f\u4e00\u7684\u5e8f\u5217\u5dee\u5f02\u3002\u67d0\u4e9b\u5e8f\u5217\u53ef\u80fd\u5728\u67d3\u8272\u4f53\u4e0a\u7f3a\u5931\u6216\u591a\u6b21\u91cd\u590d\uff0c\u56e0\u6b64\u4e0d\u540c\u4e2a\u4f53\u53ef\u80fd\u5177\u6709\u4e0d\u540c\u6570\u91cf\u7684\u57fa\u56e0\u62f7\u8d1d\u3002\u8d85\u8fc7\u4e00\u4e2a\u78b1\u57fa\u4f46\u5c11\u4e8e1000\u4e2a\u78b1\u57fa\u5bf9\u7684\u53d8\u5316\u88ab\u79f0\u4e3a\u63d2\u5165\u7f3a\u5931\u7a81\u53d8\u3002\u5f53\u8fd9\u79cd\u53d8\u5f02\u8d85\u8fc71000\u4e2a\u78b1\u57fa\u5bf9\u65f6\uff0c\u5b83\u4eec\u88ab\u79f0\u4e3a\u62f7\u8d1d\u6570\u53d8\u5f02\u3002<\/p>\n<p style=\"text-wrap: wrap;\">\u4efb\u4f55\u57fa\u56e0\u53d8\u5f02\u5bf9\u75be\u75c5\u6216\u7efc\u5408\u5f81\u7684\u8d21\u732e\u53ef\u5206\u4e3a\u7b80\u5355\uff08\u6216\u5b5f\u5fb7\u5c14\uff09\u9057\u4f20\u548c\u590d\u6742\u9057\u4f20\u3002\u901a\u5e38\uff0c\u7b80\u5355\u6216\u5b5f\u5fb7\u5c14\u7a81\u53d8\u8db3\u4ee5\u5f15\u8d77\u7279\u5b9a\u7684\u8868\u578b\uff0c\u800c\u4e0d\u9700\u8981\u989d\u5916\u7684\u9057\u4f20\u98ce\u9669\u56e0\u7d20\u3002\u8fd9\u5e76\u4e0d\u610f\u5473\u7740\u6240\u6709\u643a\u5e26\u7a81\u53d8\u7684\u4eba\u90fd\u4f1a\u8868\u73b0\u51fa\u5b8c\u5168\u76f8\u540c\u7684\u8868\u578b\uff0c\u4f46\u901a\u5e38\u7279\u5b9a\u75be\u75c5\u7b49\u4f4d\u57fa\u56e0\u4e0e\u8868\u578b\u4e4b\u95f4\u7684\u5173\u7cfb\u9ad8\u5ea6\u4e00\u81f4\uff0c\u63a5\u8fd1\u4e00\u5bf9\u4e00\u7684\u5173\u7cfb\uff08\u4f8b\u5982\u9570\u72b6\u7ec6\u80de\u6027\u8d2b\u8840\u6216\u4ea8\u5ef7\u987f\u821e\u8e48\u75c7\uff09\u3002<\/p>\n<p style=\"text-wrap: wrap;\">\u76f8\u53cd\uff0c\u590d\u6742\u9057\u4f20\u75be\u75c5\u6d89\u53ca\u591a\u4e2a\u9057\u4f20\u98ce\u9669\u56e0\u7d20\uff0c\u5b83\u4eec\u6539\u53d8\u4e86\u75be\u75c5\u53d1\u751f\u7684\u6982\u7387\uff0c\u4f46\u5e76\u975e\u5b8c\u5168\u51b3\u5b9a\u75be\u75c5\u53d1\u751f\u3002\u8fd9\u79cd\u9057\u4f20\u8d21\u732e\u53ef\u80fd\u5305\u62ec\u7f55\u89c1\u7a81\u53d8\u3001\u5e38\u89c1\u591a\u6001\u6027\u6216\u4e24\u8005\u517c\u6709\uff0c\u5e76\u4e14\u901a\u5e38\u5177\u6709\u9ad8\u5ea6\u5f02\u8d28\u6027\uff0c\u591a\u4e2a\u4e0d\u540c\u7684\u57fa\u56e0\u548c\u7b49\u4f4d\u57fa\u56e0\u53ef\u80fd\u589e\u52a0\u98ce\u9669\u6216\u63d0\u4f9b\u4fdd\u62a4\u3002\u5927\u591a\u6570\u590d\u6742\u75be\u75c5\u4e5f\u4e0e\u73af\u5883\u56e0\u7d20\u5bc6\u5207\u76f8\u5173\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"display: flex;flex-flow: row;margin: 20px 0% 10px;text-align: left;justify-content: flex-start;\">\n<section style=\"display: inline-block;vertical-align: middle;width: 15%;align-self: center;background-color: rgb(49, 116, 161);flex: 0 0 auto;height: auto;border-width: 0px;line-height: 1.4;\">\n<section style=\"text-align: justify;\">\n<p style=\"text-wrap: wrap;\"><br  \/><\/p>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: middle;width: auto;align-self: center;border-style: none;border-width: 0px;border-color: rgb(49, 116, 161) rgb(49, 116, 161) rgb(49, 116, 161) rgb(0, 137, 123);flex: 100 100 0%;height: auto;\">\n<section style=\"padding-right: 10px;padding-left: 10px;line-height: 1.5;letter-spacing: 0px;color: rgb(0, 0, 0);font-size: 18px;text-align: justify;\">\n<p style=\"text-wrap: wrap;\"><strong>2.4 \u57fa\u56e0\u5728\u8fdb\u5316\u4e2d\u7684\u4fdd\u5b88\u6027<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: middle;width: auto;align-self: center;flex: 100 100 0%;height: auto;\">\n<section style=\"margin-top: 10px;margin-bottom: 10px;\">\n<section style=\"background-color: rgb(214, 238, 214);height: 2px;\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin-top: 10px;margin-bottom: 10px;\">\n<section style=\"display: inline-block;width: 100%;border-width: 2px;border-style: dashed;border-color: rgb(164, 172, 181);padding: 10px;background-color: rgb(238, 249, 255);border-radius: 11.2px;overflow: hidden;\">\n<section style=\"color: rgb(0, 0, 0);\">\n<p style=\"text-wrap: wrap;\">2001\u5e74\uff0c\u4eba\u7c7b\u57fa\u56e0\u7ec4\u7684\u51e0\u4e4e\u5b8c\u6574\u7684\u6838\u82f7\u9178\u5e8f\u5217\u88ab\u516c\u5e03\uff0c\u540c\u65f6\u4e5f\u89e3\u7801\u4e86\u8bb8\u591a\u52a8\u7269\u7684\u57fa\u56e0\u7ec4\u3002\u901a\u8fc7\u6bd4\u8f83\u8fd9\u4e9b\u57fa\u56e0\u7ec4\uff0c\u5f97\u51fa\u4e86\u4e00\u4e2a\u4ee4\u4eba\u60ca\u8bb6\u7684\u7ed3\u8bba\uff1a\u4eba\u7c7b\u8fd9\u4e2a\u72ec\u7279\u7269\u79cd\u5e76\u4e0d\u662f\u56e0\u4e3a\u72ec\u7279\u7684\u65b0\u57fa\u56e0\u7684\u53d1\u660e\u800c\u4ea7\u751f\u7684\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin-top: 10px;margin-bottom: 10px;\">\n<section style=\"display: inline-block;width: 100%;border-width: 2px;border-style: dashed;border-color: rgb(164, 172, 181);padding: 10px;background-color: rgb(238, 249, 255);border-radius: 11.2px;overflow: hidden;\">\n<section style=\"color: rgb(0, 0, 0);\">\n<p style=\"text-wrap: wrap;\">\u867d\u7136\u4eba\u7c7b\u548c\u9ed1\u7329\u7329\u5728\u751f\u7269\u5b66\u548c\u884c\u4e3a\u4e0a\u6709\u663e\u8457\u5dee\u5f02\uff0c\u4f46\u5b83\u4eec\u5171\u4eab99%\u7684\u86cb\u767d\u8d28\u7f16\u7801\u57fa\u56e0\u3002\u6b64\u5916\uff0c\u4eba\u7c7b\u5927\u7ea620,000\u4e2a\u57fa\u56e0\u4e2d\u7684\u5927\u591a\u6570\u4e5f\u5b58\u5728\u4e8e\u5176\u4ed6\u54fa\u4e73\u52a8\u7269\u4e2d\uff0c\u5982\u5c0f\u9f20\uff0c\u800c\u4e14\u8d85\u8fc7\u4e00\u534a\u7684\u4eba\u7c7b\u57fa\u56e0\u4e0e\u65e0\u810a\u690e\u52a8\u7269\uff08\u5982\u8815\u866b\u548c\u679c\u8747\uff09\u4e2d\u7684\u57fa\u56e0\u975e\u5e38\u76f8\u4f3c\uff08\u89c1<span style=\"color: rgb(203, 47, 21);\">\u56fe2.4.1<\/span>\uff09\u3002\u8fd9\u4e00\u53d1\u73b0\u8868\u660e\uff0c\u53e4\u8001\u7684\u57fa\u56e0\u5728\u4eba\u7c7b\u4e0e\u5176\u4ed6\u52a8\u7269\u4e4b\u95f4\u662f\u5171\u4eab\u7684\uff0c\u53ea\u662f\u5b83\u4eec\u5728\u4e0d\u540c\u7269\u79cd\u4e2d\u88ab\u4ee5\u65b0\u7684\u65b9\u5f0f\u8c03\u63a7\uff0c\u624d\u4ea7\u751f\u4e86\u4eba\u7c7b\u72ec\u7279\u7684\u7279\u6027\uff0c\u5982\u590d\u6742\u601d\u7ef4\u548c\u8bed\u8a00\u7684\u80fd\u529b\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-imgfileid=\"308774064\" data-ratio=\"0.7793696275071633\" data-s=\"300,640\"  data-type=\"png\" data-w=\"698\" style=\"vertical-align: middle;width: 100%;\" src=\"http:\/\/dh.oncolab.cn\/wp-content\/uploads\/2025\/01\/wxsync-2025-01-c08777d7384b7f870585debac728fe7c.png\"  \/><\/section>\n<\/section>\n<section style=\"text-align: right;justify-content: flex-end;margin-right: 0%;margin-bottom: 10px;margin-left: 0%;display: flex;flex-flow: row;\">\n<section style=\"display: inline-block;vertical-align: top;width: 30px;border-left: 2px solid rgb(51, 122, 183);border-bottom-left-radius: 0px;border-bottom: 2px solid rgb(51, 122, 183);border-bottom-right-radius: 0px;flex: 0 0 auto;height: auto;line-height: 1;align-self: flex-start;\">\n<section style=\"text-align: justify;\">\n<p style=\"text-wrap: wrap;\"><br  \/><\/p>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: top;width: 90%;flex: 0 0 auto;height: auto;padding-left: 8px;align-self: flex-start;\">\n<section style=\"color: rgb(106, 106, 106);font-size: 15px;text-align: left;\">\n<p style=\"text-align: justify;text-wrap: wrap;\"><span style=\"text-align: left;color: rgb(203, 47, 21);\">\u56fe 2.4.1:<\/span><span style=\"text-align: left;\"> \u5927\u591a\u6570\u4eba\u7c7b\u57fa\u56e0\u4e0e\u5176\u4ed6\u7269\u79cd\u7684\u57fa\u56e0\u5b58\u5728\u5173\u8054\u3002\u53ea\u6709\u4e0d\u52301%\u7684\u4eba\u7c7b\u57fa\u56e0\u662f\u4eba\u7c7b\u6240\u7279\u6709\u7684\uff1b\u5176\u4f59\u57fa\u56e0\u5219\u53ef\u80fd\u5728\u6240\u6709\u751f\u7269\u3001\u6240\u6709\u771f\u6838\u751f\u7269\u3001\u52a8\u7269\u6216\u4ec5\u810a\u690e\u52a8\u7269\u4e2d\u5171\u4eab\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin-top: 10px;margin-bottom: 10px;\">\n<section style=\"display: inline-block;width: 100%;border-width: 2px;border-style: dashed;border-color: rgb(164, 172, 181);padding: 10px;background-color: rgb(238, 249, 255);border-radius: 11.2px;overflow: hidden;\">\n<section style=\"color: rgb(0, 0, 0);\">\n<p style=\"text-wrap: wrap;\">\u7531\u4e8e\u57fa\u56e0\u5728\u8fdb\u5316\u8fc7\u7a0b\u4e2d\u9ad8\u5ea6\u4fdd\u5b88\uff0c\u7814\u7a76\u4e00\u79cd\u52a8\u7269\u6240\u5f97\u51fa\u7684\u7ed3\u679c\u901a\u5e38\u53ef\u4ee5\u5e94\u7528\u4e8e\u5176\u4ed6\u5177\u6709\u76f8\u5e94\u57fa\u56e0\u7684\u52a8\u7269\uff0c\u8fd9\u5728\u65e0\u6cd5\u8fdb\u884c\u4eba\u7c7b\u5b9e\u9a8c\u65f6\u5c24\u4e3a\u91cd\u8981\u3002\u4f8b\u5982\uff0c\u4e0e\u4eba\u7c7b\u57fa\u56e0\u6709\u76f8\u4f3c\u6c28\u57fa\u9178\u5e8f\u5217\u7684\u5c0f\u9f20\u57fa\u56e0\uff0c\u901a\u5e38\u5728\u529f\u80fd\u4e0a\u4e0e\u76f8\u5e94\u7684\u4eba\u7c7b\u76f4\u7cfb\u540c\u6e90\u57fa\u56e0\u76f8\u4f3c\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin-top: 10px;margin-bottom: 10px;\">\n<section style=\"display: inline-block;width: 100%;border-width: 2px;border-style: dashed;border-color: rgb(164, 172, 181);padding: 10px;background-color: rgb(238, 249, 255);border-radius: 11.2px;overflow: hidden;\">\n<section style=\"color: rgb(0, 0, 0);\">\n<p style=\"text-wrap: wrap;\">\u5927\u7ea6\u4e00\u534a\u7684\u4eba\u7c7b\u57fa\u56e0\u529f\u80fd\u5df2\u901a\u8fc7\u5176\u4ed6\u751f\u7269\u4f53\u7684\u76f4\u7cfb\u540c\u6e90\u57fa\u56e0\u5f97\u5230\u8bc1\u5b9e\u6216\u63a8\u65ad\uff08\u89c1<span style=\"color: rgb(203, 47, 21);\">\u56fe2.4.2<\/span>\uff09\u3002\u4eba\u7c7b\u3001\u679c\u8747\uff0c\u751a\u81f3\u5355\u7ec6\u80de\u9175\u6bcd\u4e2d\u5171\u6709\u7684\u4e00\u7ec4\u57fa\u56e0\uff0c\u7f16\u7801\u4e86\u53c2\u4e0e\u4e2d\u95f4\u4ee3\u8c22\u3001DNA\u3001RNA\u548c\u86cb\u767d\u8d28\u5408\u6210\u3001\u7ec6\u80de\u5206\u88c2\u3001\u7ec6\u80de\u9aa8\u67b6\u7ed3\u6784\u3001\u86cb\u767d\u8d28\u8fd0\u8f93\u548c\u5206\u6ccc\u7684\u86cb\u767d\u8d28\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-imgfileid=\"308774067\" data-ratio=\"0.7681528662420383\" data-s=\"300,640\"  data-type=\"png\" data-w=\"785\" style=\"vertical-align: middle;width: 100%;\" src=\"http:\/\/dh.oncolab.cn\/wp-content\/uploads\/2025\/01\/wxsync-2025-01-bf1fd16b04944cc865a54a78c6f8828b.png\"  \/><\/section>\n<\/section>\n<section style=\"text-align: right;justify-content: flex-end;margin-right: 0%;margin-bottom: 10px;margin-left: 0%;display: flex;flex-flow: row;\">\n<section style=\"display: inline-block;vertical-align: top;width: 30px;border-left: 2px solid rgb(51, 122, 183);border-bottom-left-radius: 0px;border-bottom: 2px solid rgb(51, 122, 183);border-bottom-right-radius: 0px;flex: 0 0 auto;height: auto;line-height: 1;align-self: flex-start;\">\n<section style=\"text-align: justify;\">\n<p style=\"text-wrap: wrap;\"><br  \/><\/p>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: top;width: 90%;flex: 0 0 auto;height: auto;padding-left: 8px;align-self: flex-start;\">\n<section style=\"color: rgb(106, 106, 106);font-size: 15px;text-align: left;\">\n<p style=\"text-align: justify;text-wrap: wrap;\"><span style=\"text-align: left;color: rgb(203, 47, 21);\">\u56fe 2.4.2:&nbsp;<\/span><span style=\"text-align: left;\">26,383\u4e2a\u4eba\u7c7b\u57fa\u56e0\u7684\u9884\u6d4b\u5206\u5b50\u529f\u80fd\u5206\u7c7b\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"display: flex;flex-flow: row;margin: 20px 0% 10px;text-align: left;justify-content: flex-start;\">\n<section style=\"display: inline-block;vertical-align: middle;width: 15%;align-self: center;background-color: rgb(49, 116, 161);flex: 0 0 auto;height: auto;border-width: 0px;line-height: 1.4;\">\n<section style=\"text-align: justify;\">\n<p style=\"text-wrap: wrap;\"><br  \/><\/p>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: middle;width: auto;align-self: center;border-style: none;border-width: 0px;border-color: rgb(49, 116, 161) rgb(49, 116, 161) rgb(49, 116, 161) rgb(0, 137, 123);flex: 100 100 0%;height: auto;\">\n<section style=\"padding-right: 10px;padding-left: 10px;line-height: 1.5;letter-spacing: 0px;color: rgb(0, 0, 0);font-size: 18px;text-align: justify;\">\n<p style=\"text-wrap: wrap;\"><strong>2.5 \u5728\u52a8\u7269\u6a21\u578b\u4e2d\u7814\u7a76\u884c\u4e3a\u7684\u9057\u4f20\u8c03\u63a7<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin-top: 10px;margin-bottom: 10px;\">\n<section style=\"display: inline-block;width: 100%;border-width: 2px;border-style: dashed;border-color: rgb(164, 172, 181);padding: 10px;background-color: rgb(238, 249, 255);border-radius: 11.2px;overflow: hidden;\">\n<section style=\"color: rgb(0, 0, 0);\">\n<p style=\"text-wrap: wrap;\">\u7531\u4e8e\u4eba\u7c7b\u4e0e\u52a8\u7269\u57fa\u56e0\u5728\u8fdb\u5316\u4e0a\u9ad8\u5ea6\u4fdd\u5b88\uff0c\u5229\u7528\u52a8\u7269\u6a21\u578b\u7814\u7a76\u57fa\u56e0\u3001\u86cb\u767d\u8d28\u548c\u795e\u7ecf\u56de\u8def\u4e4b\u95f4\u7684\u5173\u7cfb\u2014\u2014\u8fd9\u4e9b\u5173\u7cfb\u6784\u6210\u4e86\u884c\u4e3a\u7684\u57fa\u7840\u2014\u2014\u53ef\u4ee5\u4e3a\u6211\u4eec\u7406\u89e3\u8fd9\u4e9b\u673a\u5236\u5728\u4eba\u7c7b\u4e2d\u7684\u4f5c\u7528\u63d0\u4f9b\u6df1\u523b\u89c1\u89e3\u3002\u5728\u57fa\u56e0\u529f\u80fd\u7814\u7a76\u4e2d\uff0c\u5df2\u6709\u4e24\u79cd\u91cd\u8981\u7b56\u7565\u88ab\u5e7f\u6cdb\u5e94\u7528\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin-top: 10px;margin-bottom: 10px;\">\n<section style=\"display: inline-block;width: 100%;border-width: 2px;border-style: dashed;border-color: rgb(164, 172, 181);padding: 10px;background-color: rgb(238, 249, 255);border-radius: 11.2px;overflow: hidden;\">\n<section style=\"color: rgb(0, 0, 0);\">\n<p style=\"text-wrap: wrap;\">\u5728\u7ecf\u5178\u9057\u4f20\u5206\u6790\u4e2d\uff0c\u9996\u5148\u901a\u8fc7\u5316\u5b66\u6216\u8f90\u5c04\u8bf1\u53d8\u5bf9\u751f\u7269\u4f53\u8fdb\u884c\u968f\u673a\u7a81\u53d8\u5904\u7406\uff0c\u7136\u540e\u7b5b\u9009\u51fa\u90a3\u4e9b\u5f71\u54cd\u7279\u5b9a\u884c\u4e3a\uff08\u5982\u7761\u7720\uff09\u7684\u53ef\u9057\u4f20\u53d8\u5316\u3002\u8fd9\u79cd\u65b9\u6cd5\u4e0d\u504f\u5411\u4efb\u4f55\u7279\u5b9a\u57fa\u56e0\uff0c\u800c\u662f\u5bf9\u6240\u6709\u53ef\u80fd\u5bfc\u81f4\u53ef\u68c0\u6d4b\u53d8\u5316\u7684\u7a81\u53d8\u8fdb\u884c\u968f\u673a\u641c\u7d22\u3002\u901a\u8fc7\u8ffd\u8e2a\u8fd9\u4e9b\u53ef\u9057\u4f20\u7684\u53d8\u5316\uff0c\u53ef\u4ee5\u8bc6\u522b\u51fa\u5728\u7a81\u53d8\u4f53\u4e2d\u88ab\u6539\u53d8\u7684\u5177\u4f53\u57fa\u56e0\u3002\u56e0\u6b64\uff0c\u7ecf\u5178\u9057\u4f20\u5b66\u7684\u53d1\u73b0\u8def\u5f84\u662f\u4ece\u8868\u578b\u5230\u57fa\u56e0\u578b\uff0c\u4ece\u751f\u7269\u4f53\u5230\u57fa\u56e0\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin-top: 10px;margin-bottom: 10px;\">\n<section style=\"display: inline-block;width: 100%;border-width: 2px;border-style: dashed;border-color: rgb(164, 172, 181);padding: 10px;background-color: rgb(238, 249, 255);border-radius: 11.2px;overflow: hidden;\">\n<section style=\"color: rgb(0, 0, 0);\">\n<p style=\"text-wrap: wrap;\">\u76f8\u53cd\uff0c\u5728\u53cd\u5411\u9057\u4f20\u5b66\u4e2d\uff0c\u7814\u7a76\u8005\u9488\u5bf9\u7279\u5b9a\u611f\u5174\u8da3\u7684\u57fa\u56e0\u8fdb\u884c\u64cd\u63a7\uff0c\u521b\u5efa\u8f6c\u57fa\u56e0\u52a8\u7269\uff0c\u5e76\u7814\u7a76\u8fd9\u4e9b\u57fa\u56e0\u53d8\u5316\u5bf9\u52a8\u7269\u7684\u5f71\u54cd\u3002\u8fd9\u79cd\u7b56\u7565\u5177\u6709\u9488\u5bf9\u6027\u548c\u65b9\u5411\u6027\u2014\u2014\u4ece\u7279\u5b9a\u57fa\u56e0\u5165\u624b\uff0c\u53d1\u73b0\u8def\u5f84\u662f\u4ece\u57fa\u56e0\u578b\u5230\u8868\u578b\uff0c\u4ece\u57fa\u56e0\u5230\u751f\u7269\u4f53\u3002\u8fd9\u4e24\u79cd\u5b9e\u9a8c\u7b56\u7565\u53ca\u5176\u5404\u79cd\u53d8\u4f53\u6784\u6210\u4e86\u5b9e\u9a8c\u9057\u4f20\u5b66\u7684\u57fa\u7840\u3002\u57fa\u56e0\u64cd\u4f5c\u901a\u5e38\u5728\u5b9e\u9a8c\u52a8\u7269\u4e2d\u8fdb\u884c\uff0c\u800c\u4e0d\u662f\u5728\u4eba\u7c7b\u8eab\u4e0a\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"color: rgb(203, 47, 21);line-height: 1.5;\">\n<p style=\"text-wrap: wrap;\"><strong>2.5.1 \u8f6c\u5f55\u632f\u8361\u5668\u8c03\u8282\u82cd\u8747\u3001\u5c0f\u9f20\u548c\u4eba\u7c7b\u7684\u663c\u591c\u8282\u5f8b<\/strong><\/p>\n<\/section>\n<section style=\"margin-top: 10px;margin-bottom: 10px;\">\n<section style=\"display: inline-block;width: 100%;border-width: 2px;border-style: dashed;border-color: rgb(164, 172, 181);padding: 10px;background-color: rgb(238, 249, 255);border-radius: 11.2px;overflow: hidden;\">\n<section style=\"color: rgb(0, 0, 0);\">\n<p style=\"text-wrap: wrap;\">20\u4e16\u7eaa70\u5e74\u4ee3\uff0c\u897f\u6469\u00b7\u672c\u6cfd\u53ca\u5176\u56e2\u961f\u542f\u52a8\u4e86\u9996\u6b21\u5927\u89c4\u6a21\u7814\u7a76\uff0c\u63a2\u7d22\u57fa\u56e0\u5982\u4f55\u5f71\u54cd\u884c\u4e3a\u3002\u4ed6\u4eec\u91c7\u7528\u968f\u673a\u8bf1\u53d8\u548c\u7ecf\u5178\u9057\u4f20\u5206\u6790\u7684\u65b9\u6cd5\uff0c\u8bc6\u522b\u51fa\u4e86\u5f71\u54cd\u9ed1\u8179\u679c\u8747\uff08Drosophila melanogaster\uff09\u5b66\u4e60\u884c\u4e3a\u548c\u5148\u5929\u884c\u4e3a\u7684\u7a81\u53d8\uff0c\u5305\u62ec\u663c\u591c\u8282\u5f8b\uff0824\u5c0f\u65f6\uff09\u8282\u594f\u3001\u6c42\u5076\u884c\u4e3a\u3001\u8fd0\u52a8\u3001\u89c6\u89c9\u611f\u77e5\u548c\u8bb0\u5fc6\uff08\u89c1<span style=\"color: rgb(82, 120, 56);\">Box 2.2<\/span>\u548c<span style=\"color: rgb(82, 120, 56);\">Box 2.3<\/span>\uff09\u3002\u8fd9\u4e9b\u8bf1\u5bfc\u7a81\u53d8\u6781\u5927\u5730\u63a8\u52a8\u4e86\u6211\u4eec\u5bf9\u57fa\u56e0\u5728\u884c\u4e3a\u4e2d\u4f5c\u7528\u7684\u7406\u89e3\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"transform-origin: left top;\">\n<section style=\"text-align: center;justify-content: center;display: flex;flex-flow: row;margin-top: 10px;margin-bottom: 4px;\">\n<section style=\"display: inline-block;vertical-align: middle;width: auto;min-width: 5%;flex: 0 0 auto;height: auto;align-self: center;\">\n<section style=\"display: flex;width: 100%;flex-flow: column;\">\n<section style=\"transform: rotateZ(19deg) rotateX(31deg) rotateY(326deg);transform-origin: center center;z-index: 1;\">\n<section style=\"justify-content: center;display: flex;flex-flow: row;\">\n<section style=\"display: inline-block;width: auto;vertical-align: top;align-self: flex-start;flex: 0 0 auto;min-width: 5%;height: auto;\">\n<section style=\"z-index: auto;\">\n<section style=\"text-align: left;justify-content: flex-start;display: flex;flex-flow: row;\">\n<section style=\"display: inline-block;width: auto;vertical-align: middle;align-self: center;flex: 0 0 auto;min-width: 5%;height: auto;padding-right: 5px;padding-left: 5px;border-radius: 6px;overflow: hidden;background-color: rgb(214, 238, 214);\">\n<section style=\"text-align: center;\">\n<section style=\"font-size: 20px;color: rgb(0, 0, 0);\">\n<p>Box 2.2 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style=\"text-wrap: wrap;\">\u5f53\u8fd9\u4e24\u79cd\u5c0f\u9f20\u4ea4\u914d\u65f6\uff0c\u4e00\u4e9b\u540e\u4ee3\u5c06\u540c\u65f6\u643a\u5e26\u8fd9\u4e24\u79cd\u8f6c\u57fa\u56e0\u3002\u5728\u8fd9\u4e9b\u5c0f\u9f20\u4e2d\uff0ctTA\u4e0e\u56db\u73af\u7d20\u53cd\u5e94\u5143\u4ef6\u542f\u52a8\u5b50\u7ed3\u5408\u5e76\u6fc0\u6d3b\u4e0b\u6e38\u7684\u8f6c\u57fa\u56e0\u8868\u8fbe\u3002tTA\u7279\u522b\u6709\u7528\uff0c\u56e0\u4e3a\u5b83\u5728\u4e0e\u56db\u73af\u7d20\u7c7b\u6297\u751f\u7d20\u7ed3\u5408\u65f6\u4f1a\u5931\u6d3b\uff0c\u4ece\u800c\u901a\u8fc7\u7ed9\u5c0f\u9f20\u670d\u7528\u6297\u751f\u7d20\u6765\u8c03\u8282\u8f6c\u57fa\u56e0\u7684\u8868\u8fbe\u3002\u8fd8\u53ef\u4ee5\u521b\u5efa\u8868\u8fbe\u4e00\u79cd\u79f0\u4e3a\u53cd\u5411\u56db\u73af\u7d20\u6fc0\u6d3b\u56e0\u5b50\uff08rtTA\uff09\u7684\u7a81\u53d8\u5f62\u5f0f\u7684\u5c0f\u9f20\u3002\u5728\u8fd9\u79cd\u60c5\u51b5\u4e0b\uff0c\u8f6c\u57fa\u56e0\u901a\u5e38\u662f\u5173\u95ed\u7684\uff0c\u9664\u975e\u7ed9\u5c0f\u9f20\u5582\u98df\u6297\u751f\u7d20\u591a\u897f\u73af\u7d20\uff08\u89c1<span style=\"color: rgb(203, 47, 21);\">\u56fe2.5.3<\/span>\uff09\u3002<\/p>\n<p style=\"text-wrap: wrap;\"><br  \/><\/p>\n<p style=\"text-wrap: wrap;\"><strong>\u6838\u7cd6\u6838\u9178\u5e72\u6270\u548cCRISPR\u6539\u53d8\u57fa\u56e0\u529f\u80fd<\/strong><\/p>\n<p style=\"text-wrap: wrap;\">\u6700\u540e\uff0c\u7814\u7a76\u4eba\u5458\u8fd8\u53ef\u4ee5\u4f7f\u7528\u73b0\u4ee3\u5206\u5b50\u5de5\u5177\u9776\u5411\u5e76\u706d\u6d3b\u57fa\u56e0\u3002\u4e00\u79cd\u65b9\u6cd5\u662f\u6838\u7cd6\u6838\u9178\u5e72\u6270\uff08RNAi\uff09\uff0c\u8be5\u65b9\u6cd5\u5229\u7528\u4e86\u771f\u6838\u7ec6\u80de\u4e2d\u5927\u591a\u6570\u53cc\u94feRNA\u88ab\u5e38\u89c4\u964d\u89e3\u7684\u673a\u5236\u3002\u5373\u4f7fRNA\u53ea\u6709\u4e00\u90e8\u5206\u662f\u53cc\u94fe\u7684\uff0c\u6574\u4e2aRNA\u4e5f\u4f1a\u88ab\u964d\u89e3\u3002\u901a\u8fc7\u5f15\u5165\u4e00\u4e2a\u77ed\u7684RNA\u5e8f\u5217\uff0c\u4eba\u4e3a\u5730\u4f7f\u9009\u5b9a\u7684mRNA\u5f62\u6210\u53cc\u94fe\uff0c\u7814\u7a76\u4eba\u5458\u53ef\u4ee5\u6fc0\u6d3b\u8fd9\u4e00\u8fc7\u7a0b\uff0c\u4ece\u800c\u964d\u4f4e\u7279\u5b9a\u57fa\u56e0\u7684mRNA\u6c34\u5e73\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"transform-origin: left top;\">\n<section style=\"text-align: center;justify-content: center;display: flex;flex-flow: row;margin-top: 10px;margin-bottom: 4px;\">\n<section style=\"display: inline-block;vertical-align: middle;width: auto;min-width: 5%;flex: 0 0 auto;height: auto;align-self: center;\">\n<section style=\"display: flex;width: 100%;flex-flow: column;\">\n<section style=\"transform: rotateZ(19deg) rotateX(31deg) rotateY(326deg);transform-origin: center center;z-index: 1;\">\n<section style=\"justify-content: center;display: flex;flex-flow: row;\">\n<section style=\"display: inline-block;width: auto;vertical-align: top;align-self: flex-start;flex: 0 0 auto;min-width: 5%;height: auto;\">\n<section style=\"z-index: auto;\">\n<section style=\"text-align: left;justify-content: flex-start;display: flex;flex-flow: row;\">\n<section style=\"display: inline-block;width: auto;vertical-align: middle;align-self: center;flex: 0 0 auto;min-width: 5%;height: auto;padding-right: 5px;padding-left: 5px;border-radius: 6px;overflow: hidden;background-color: rgb(214, 238, 214);\">\n<section style=\"text-align: center;\">\n<section style=\"font-size: 20px;color: rgb(0, 0, 0);\">\n<p>Box 2.3 (\u8f6c\u57fa\u56e0\u5728\u679c\u8747\u548c\u5c0f\u9f20\u4e2d\u7684\u5f15\u5165)<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: middle;width: auto;align-self: center;flex: 100 100 0%;height: auto;\">\n<section style=\"margin-top: 10px;margin-bottom: 10px;\">\n<section style=\"background-color: rgb(214, 238, 214);height: 2px;\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"text-align: center;justify-content: center;display: flex;flex-flow: row;margin-bottom: 10px;\">\n<section style=\"display: inline-block;width: 100%;vertical-align: top;align-self: flex-start;flex: 0 0 auto;height: auto;background-color: rgb(241, 248, 240);padding: 21px;line-height: 1.5;\">\n<section style=\"text-align: justify;\">\n<p style=\"text-wrap: wrap;\">\u901a\u8fc7\u5c06DNA\u6ce8\u5c04\u5230\u65b0\u53d7\u7cbe\u5375\u7684\u7ec6\u80de\u6838\u4e2d\uff0c\u53ef\u4ee5\u5728\u5c0f\u9f20\u4f53\u5185\u5b9e\u9a8c\u6027\u5730\u5f15\u5165\u57fa\u56e0\uff08\u89c1<span style=\"color: rgb(203, 47, 21);\">\u56fe2.5.4<\/span>\uff09\u3002\u5728\u4e00\u4e9b\u6ce8\u5c04\u7684\u5375\u5b50\u4e2d\uff0c\u65b0\u7684\u57fa\u56e0\u6216\u8f6c\u57fa\u56e0\u4f1a\u968f\u673a\u6574\u5408\u5230\u67d3\u8272\u4f53\u4e0a\u7684\u67d0\u4e2a\u4f4d\u7f6e\u3002\u7531\u4e8e\u80da\u80ce\u5904\u4e8e\u5355\u7ec6\u80de\u9636\u6bb5\uff0c\u8fd9\u4e2a\u6574\u5408\u7684\u57fa\u56e0\u4f1a\u5728\u7ec6\u80de\u5206\u88c2\u8fc7\u7a0b\u4e2d\u88ab\u590d\u5236\uff0c\u6700\u7ec8\u8fdb\u5165\u52a8\u7269\u7684\u6240\u6709\uff08\u6216\u51e0\u4e4e\u6240\u6709\uff09\u7ec6\u80de\uff0c\u5305\u62ec\u751f\u6b96\u7ec6\u80de\u3002<br  \/><\/p>\n<p style=\"text-wrap: wrap;\">\u4f8b\u5982\uff0c\u901a\u8fc7\u5c06\u7528\u4e8e\u4ea7\u751f\u8272\u7d20\u7684\u57fa\u56e0\u6ce8\u5c04\u5230\u6765\u81ea\u767d\u5316\u75c5\u83cc\u682a\u7684\u53d7\u7cbe\u5375\u4e2d\uff0c\u53ef\u4ee5\u6062\u590d\u5c0f\u9f20\u7684\u5916\u89c2\u989c\u8272\u3002\u6709\u8272\u7d20\u6591\u5757\u7684\u5c0f\u9f20\u8868\u660eDNA\u6210\u529f\u6574\u5408\u5e76\u8868\u8fbe\u3002\u901a\u8fc7\u6d4b\u8bd5\u6ce8\u5c04\u540e\u52a8\u7269\u7684DNA\u6837\u672c\uff0c\u53ef\u4ee5\u786e\u8ba4\u8f6c\u57fa\u56e0\u7684\u5b58\u5728\u3002<\/p>\n<p style=\"text-wrap: wrap;\">\u5728\u679c\u8747\u4e2d\u4e5f\u4f7f\u7528\u4e86\u7c7b\u4f3c\u7684\u65b9\u6cd5\u3002\u7814\u7a76\u4eba\u5458\u5c06\u5f85\u6ce8\u5c04\u7684DNA\u514b\u9686\u5230\u53ef\u8f6c\u5ea7\u5143\u4ef6\uff08P\u5143\u4ef6\uff09\u4e2d\u3002\u5f53\u6ce8\u5c04\u5230\u80da\u80ce\u4e2d\u65f6\uff0c\u8fd9\u4e9bDNA\u88ab\u63d2\u5165\u5230\u751f\u6b96\u7ec6\u80de\u6838\u7684DNA\u4e2d\u3002P\u5143\u4ef6\u53ef\u4ee5\u88ab\u8bbe\u8ba1\u4e3a\u5728\u7279\u5b9a\u65f6\u95f4\u548c\u7279\u5b9a\u7ec6\u80de\u4e2d\u8868\u8fbe\u57fa\u56e0\u3002\u8f6c\u57fa\u56e0\u53ef\u4ee5\u662f\u6062\u590d\u7a81\u53d8\u4f53\u529f\u80fd\u7684\u91ce\u751f\u578b\u57fa\u56e0\uff0c\u6216\u8005\u662f\u8bbe\u8ba1\u7528\u6765\u6539\u53d8\u5176\u4ed6\u57fa\u56e0\u8868\u8fbe\u6216\u7f16\u7801\u7279\u5b9a\u53d8\u5f02\u86cb\u767d\u8d28\u7684\u57fa\u56e0\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin-top: 10px;margin-bottom: 10px;\">\n<section style=\"display: inline-block;width: 100%;border-width: 2px;border-style: dashed;border-color: rgb(164, 172, 181);padding: 10px;background-color: rgb(238, 249, 255);border-radius: 11.2px;overflow: hidden;\">\n<section style=\"color: rgb(0, 0, 0);\">\n<p style=\"text-wrap: wrap;\">\u6211\u4eec\u5bf9\u663c\u591c\u8282\u5f8b\u884c\u4e3a\u8c03\u63a7\u7684\u9057\u4f20\u57fa\u7840\u6709\u4e86\u7279\u522b\u6df1\u5165\u7684\u8ba4\u8bc6\u3002\u52a8\u7269\u7684\u663c\u591c\u8282\u5f8b\u5c06\u67d0\u4e9b\u884c\u4e3a\u4e0e\u5927\u7ea624\u5c0f\u65f6\u7684\u5468\u671f\u540c\u6b65\uff0c\u8fd9\u4e2a\u5468\u671f\u4e0e\u592a\u9633\u7684\u5347\u8d77\u548c\u843d\u4e0b\u76f8\u534f\u8c03\u3002\u663c\u591c\u8282\u5f8b\u7684\u6838\u5fc3\u662f\u4e00\u4e2a\u5185\u5728\u7684\u751f\u7269\u949f\uff0c\u5b83\u4ee524\u5c0f\u65f6\u4e3a\u5468\u671f\u632f\u8361\u3002\u7531\u4e8e\u8fd9\u4e2a\u751f\u7269\u949f\u5177\u6709\u5185\u5728\u7684\u5468\u671f\u6027\uff0c\u5373\u4f7f\u5728\u6ca1\u6709\u5149\u7167\u6216\u5176\u4ed6\u73af\u5883\u5f71\u54cd\u7684\u60c5\u51b5\u4e0b\uff0c\u663c\u591c\u8282\u5f8b\u884c\u4e3a\u4e5f\u80fd\u6301\u7eed\u5b58\u5728\u3002<\/p>\n<p style=\"text-wrap: wrap;\">\u751f\u7269\u949f\u53ef\u4ee5\u88ab\u91cd\u7f6e\uff0c\u56e0\u6b64\u5f53\u663c\u591c\u5faa\u73af\u53d1\u751f\u53d8\u5316\u65f6\uff0c\u5185\u5728\u632f\u8361\u5668\u4e5f\u4f1a\u76f8\u5e94\u8c03\u6574\uff0c\u8fd9\u5c31\u662f\u65c5\u884c\u8005\u65f6\u5dee\u53cd\u5e94\u7684\u751f\u7269\u5b66\u57fa\u7840\u3002\u5149\u4fe1\u53f7\u901a\u8fc7\u773c\u775b\u4f20\u9012\u5230\u5927\u8111\uff0c\u91cd\u65b0\u8bbe\u5b9a\u751f\u7269\u949f\uff0c\u6700\u7ec8\u9a71\u52a8\u7279\u5b9a\u7684\u884c\u4e3a\u6a21\u5f0f\uff0c\u5982\u7761\u7720\u548c\u8fd0\u52a8\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-imgfileid=\"308774069\" data-ratio=\"1.2942122186495177\" data-s=\"300,640\"  data-type=\"png\" data-w=\"622\" style=\"vertical-align: middle;width: 100%;\" src=\"http:\/\/dh.oncolab.cn\/wp-content\/uploads\/2025\/01\/wxsync-2025-01-9084c29743a48315059c315fbafa601a.png\"  \/><\/section>\n<\/section>\n<section style=\"text-align: right;justify-content: flex-end;margin-right: 0%;margin-bottom: 10px;margin-left: 0%;display: flex;flex-flow: row;\">\n<section style=\"display: inline-block;vertical-align: top;width: 30px;border-left: 2px solid rgb(51, 122, 183);border-bottom-left-radius: 0px;border-bottom: 2px solid rgb(51, 122, 183);border-bottom-right-radius: 0px;flex: 0 0 auto;height: auto;line-height: 1;align-self: flex-start;\">\n<section style=\"text-align: justify;\">\n<p style=\"text-wrap: wrap;\"><br  \/><\/p>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: top;width: 90%;flex: 0 0 auto;height: auto;padding-left: 8px;align-self: flex-start;\">\n<section style=\"color: rgb(106, 106, 106);font-size: 15px;text-align: left;\">\n<p style=\"text-align: justify;text-wrap: wrap;\"><span style=\"text-align: left;color: rgb(203, 47, 21);\">\u56fe 2.5.1:&nbsp;<\/span><span style=\"text-align: left;\">\u7a81\u53d8\u5c0f\u9f20\u83cc\u682a\u7684\u751f\u6210\u8fc7\u7a0b\u3002<\/span><\/p>\n<p>A. \u751f\u6210\u5177\u6709\u7279\u5b9a\u9776\u5411\u7a81\u53d8\u7684\u5c0f\u9f20\u80da\u80ce\u5e72\u7ec6\u80de\u3002<\/p>\n<p>B. \u5229\u7528\u7ecf\u8fc7\u57fa\u56e0\u4fee\u6539\u7684\u80da\u80ce\u5e72\u7ec6\u80de\u6765\u521b\u9020\u8f6c\u57fa\u56e0\u5c0f\u9f20\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;width: 100%;height: auto;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-imgfileid=\"308774068\" data-ratio=\"0.9609375\" data-s=\"300,640\"  data-type=\"png\" data-w=\"768\" style=\"vertical-align: middle;width: 100%;\" src=\"http:\/\/dh.oncolab.cn\/wp-content\/uploads\/2025\/01\/wxsync-2025-01-c6a38727e788fbfe1893eee72e16c99f.png\"  \/><\/section>\n<\/section>\n<section style=\"text-align: right;justify-content: flex-end;margin-right: 0%;margin-bottom: 10px;margin-left: 0%;display: flex;flex-flow: row;\">\n<section style=\"display: inline-block;vertical-align: top;width: 30px;border-left: 2px solid rgb(51, 122, 183);border-bottom-left-radius: 0px;border-bottom: 2px solid rgb(51, 122, 183);border-bottom-right-radius: 0px;flex: 0 0 auto;height: auto;line-height: 1;align-self: flex-start;\">\n<section style=\"text-align: justify;\">\n<p style=\"text-wrap: wrap;\"><br  \/><\/p>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: top;width: 90%;flex: 0 0 auto;height: auto;padding-left: 8px;align-self: flex-start;\">\n<section style=\"color: rgb(106, 106, 106);font-size: 15px;text-align: left;\">\n<p style=\"text-align: justify;text-wrap: wrap;\"><span style=\"color: rgb(203, 47, 21);\">\u56fe 2.5.2:&nbsp;<\/span><span style=\"text-align: left;\">Cre\/loxP \u7cfb\u7edf\u7528\u4e8e\u9009\u62e9\u6027\u533a\u57df\u57fa\u56e0\u6572\u9664\u3002<\/span><\/p>\n<p>A. \u57f9\u80b2\u4e86\u4e00\u79cd\u5c0f\u9f20\u54c1\u7cfb\uff0c\u5176\u4e2d\u7f16\u7801 N-\u7532\u57fa-D-\u5929\u51ac\u6c28\u9178\u53d7\u4f53 NR1 \u4e9a\u57fa\u7684\u57fa\u56e0\u88ab loxP \u5143\u4ef6\u5305\u56f4\uff08\u8f6c\u57fa\u56e0\u5c0f\u9f20\u54c1\u7cfb 1\uff09\u3002\u8fd9\u4e9b\u201cfloxed NR1\u201d\u5c0f\u9f20\u968f\u540e\u4e0e\u7b2c\u4e8c\u79cd\u5c0f\u9f20\u54c1\u7cfb\u6742\u4ea4\uff0c\u8be5\u54c1\u7cfb\u5728\u7279\u5b9a\u7ec6\u80de\u6216\u7ec4\u7ec7\u7c7b\u578b\u4e2d\u8868\u8fbe Cre \u91cd\u7ec4\u9176\uff08\u8f6c\u57fa\u56e0\u5c0f\u9f20\u54c1\u7cfb 2\uff09\u3002\u5728\u8fd9\u4e2a\u4f8b\u5b50\u4e2d\uff0cCre \u57fa\u56e0\u7684\u8868\u8fbe\u7531\u9499\/\u9499\u8c03\u86cb\u767d\u4f9d\u8d56\u6027\u86cb\u767d\u6fc0\u9176 2a \u542f\u52a8\u5b50\u9a71\u52a8\u3002\u5728\u643a\u5e26 Cre \u91cd\u7ec4\u9176\u8f6c\u57fa\u56e0\u4e14\u4e3a Floxy \u57fa\u56e0\u7eaf\u5408\u7684\u540e\u4ee3\u4e2d\uff0cCre \u4ecb\u5bfc\u7684 loxP \u91cd\u7ec4\u5c06\u5220\u9664 Floxy \u57fa\u56e0\uff0c\u4e14\u8fd9\u4e00\u8fc7\u7a0b\u4ec5\u53d1\u751f\u5728\u8868\u8fbe Cre \u7684\u7ec6\u80de\u7c7b\u578b\u4e2d\u3002<\/p>\n<p>B. \u901a\u8fc7\u539f\u4f4d\u6742\u4ea4\u68c0\u6d4b\u91ce\u751f\u578b\u548c\u7a81\u53d8\u5c0f\u9f20\u6d77\u9a6c\u5207\u7247\u4e2d NR1 \u4e9a\u57fa\u7684 mRNA \u8868\u8fbe\u60c5\u51b5\u3002\u7ed3\u679c\u663e\u793a\uff0c\u7a81\u53d8\u5c0f\u9f20\u7684\u6d77\u9a6c\u963f\u8499\u89d2 1 \u533a\u4e2d NR1 \u7684 mRNA \u8868\u8fbe\uff08\u6697\u67d3\u8272\uff09\u663e\u8457\u51cf\u5c11\uff0c\u800c\u5728\u963f\u8499\u89d2 3 \u548c\u9f7f\u72b6\u56de\u533a\u5219\u4fdd\u6301\u6b63\u5e38\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"text-wrap: wrap;\"><br  \/><\/p>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-imgfileid=\"308774070\" data-ratio=\"1.062700964630225\" data-s=\"300,640\"  data-type=\"png\" data-w=\"622\" style=\"vertical-align: middle;width: 100%;\" src=\"http:\/\/dh.oncolab.cn\/wp-content\/uploads\/2025\/01\/wxsync-2025-01-e6fc47ecb42d0b2ee42f0a6abe85be74.png\"  \/><\/section>\n<\/section>\n<section style=\"text-align: right;justify-content: flex-end;margin-right: 0%;margin-bottom: 10px;margin-left: 0%;display: flex;flex-flow: row;\">\n<section style=\"display: inline-block;vertical-align: top;width: 30px;border-left: 2px solid rgb(51, 122, 183);border-bottom-left-radius: 0px;border-bottom: 2px solid rgb(51, 122, 183);border-bottom-right-radius: 0px;flex: 0 0 auto;height: auto;line-height: 1;align-self: flex-start;\">\n<section style=\"text-align: justify;\">\n<p style=\"text-wrap: wrap;\"><br  \/><\/p>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: top;width: 90%;flex: 0 0 auto;height: auto;padding-left: 8px;align-self: flex-start;\">\n<section style=\"color: rgb(106, 106, 106);font-size: 15px;text-align: justify;\">\n<p style=\"text-wrap: wrap;\"><span style=\"color: rgb(203, 47, 21);\">\u56fe 2.5.3:&nbsp;<\/span>\u56db\u73af\u7d20\u7cfb\u7edf\u7528\u4e8e\u8f6c\u57fa\u56e0\u8868\u8fbe\u7684\u65f6\u95f4\u548c\u7a7a\u95f4\u8c03\u63a7\u3002<\/p>\n<p style=\"text-wrap: wrap;\">\u57f9\u80b2\u4e86\u4e24\u4e2a\u72ec\u7acb\u7684\u8f6c\u57fa\u56e0\u5c0f\u9f20\u54c1\u7cfb\u3002\u4e00\u4e2a\u54c1\u7cfb\u5728\u9499\/\u9499\u8c03\u86cb\u767d\u4f9d\u8d56\u6027\u86cb\u767d\u6fc0\u9176 2a \u542f\u52a8\u5b50\u7684\u63a7\u5236\u4e0b\u8868\u8fbe\u56db\u73af\u7d20\u6fc0\u6d3b\u56e0\u5b50\uff0c\u8fd9\u662f\u4e00\u79cd\u7ecf\u8fc7\u5de5\u7a0b\u6539\u9020\u7684\u86cb\u767d\u8d28\uff0c\u80fd\u591f\u7ed3\u5408\u5e76\u8bc6\u522b\u7ec6\u83cc\u56db\u73af\u7d20\u53cd\u5e94\u5143\u4ef6\u3002\u7b2c\u4e8c\u4e2a\u54c1\u7cfb\u643a\u5e26\u4e00\u4e2a\u53d7\u56db\u73af\u7d20\u53cd\u5e94\u5143\u4ef6\u63a7\u5236\u7684\u611f\u5174\u8da3\u7684\u8f6c\u57fa\u56e0\uff08\u5728\u6b64\u4f8b\u4e2d\u4e3a\u4e00\u79cd\u7ec4\u6210\u578b\u6d3b\u6027\u7684\u9499\/\u9499\u8c03\u86cb\u767d\u4f9d\u8d56\u6027\u86cb\u767d\u6fc0\u9176 2\uff09\uff0c\u8fd9\u79cd\u6fc0\u9176\u5728\u6ca1\u6709 Ca<sup>2+ <\/sup>\u7684\u60c5\u51b5\u4e0b\u4ecd\u80fd\u4fdd\u6301\u6d3b\u6027\u3002\u5f53\u8fd9\u4e24\u4e2a\u54c1\u7cfb\u4ea4\u914d\u540e\uff0c\u540e\u4ee3\u7684\u5c0f\u9f20\u5728\u524d\u8111\u4e2d\u4ee5\u7279\u5b9a\u6a21\u5f0f\u8868\u8fbe\u56db\u73af\u7d20\u6fc0\u6d3b\u56e0\u5b50\u86cb\u767d\u3002\u5f53\u56db\u73af\u7d20\u6fc0\u6d3b\u56e0\u5b50\u86cb\u767d\u4e0e\u56db\u73af\u7d20\u53cd\u5e94\u5143\u4ef6\u7ed3\u5408\u65f6\uff0c\u4fbf\u4f1a\u6fc0\u6d3b\u4e0b\u6e38\u8f6c\u57fa\u56e0\u7684\u8868\u8fbe\u3002\u901a\u8fc7\u7ed9\u8fd9\u4e9b\u5c0f\u9f20\u670d\u7528\u56db\u73af\u7d20\uff08\u6216\u591a\u897f\u73af\u7d20\uff09\uff0c\u53ef\u4ee5\u4f7f\u56db\u73af\u7d20\u6fc0\u6d3b\u56e0\u5b50\u86cb\u767d\u53d1\u751f\u6784\u8c61\u53d8\u5316\uff0c\u89e3\u9664\u4e0e\u56db\u73af\u7d20\u53cd\u5e94\u5143\u4ef6\u7684\u7ed3\u5408\uff0c\u4ece\u800c\u963b\u65ad\u8f6c\u57fa\u56e0\u7684\u8868\u8fbe\u3002\u901a\u8fc7\u8fd9\u79cd\u65b9\u5f0f\uff0c\u5c0f\u9f20\u53ef\u4ee5\u5728\u524d\u8111\u4e2d\u8868\u8fbe\u9499\/\u9499\u8c03\u86cb\u767d\u4f9d\u8d56\u6027\u86cb\u767d\u6fc0\u9176 2\u2013Asp286\uff0c\u5e76\u901a\u8fc7\u65bd\u7528\u591a\u897f\u73af\u7d20\u6765\u63a7\u5236\u8fd9\u79cd\u8868\u8fbe\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-imgfileid=\"308774071\" data-ratio=\"1.346938775510204\" data-s=\"300,640\"  data-type=\"png\" data-w=\"588\" style=\"vertical-align: middle;width: 100%;\" src=\"http:\/\/dh.oncolab.cn\/wp-content\/uploads\/2025\/01\/wxsync-2025-01-60f7507d40314e897d6d4f7b37488ce8.png\"  \/><\/section>\n<\/section>\n<section style=\"text-align: right;justify-content: flex-end;margin-right: 0%;margin-bottom: 10px;margin-left: 0%;display: flex;flex-flow: row;\">\n<section style=\"display: inline-block;vertical-align: top;width: 30px;border-left: 2px solid rgb(51, 122, 183);border-bottom-left-radius: 0px;border-bottom: 2px solid rgb(51, 122, 183);border-bottom-right-radius: 0px;flex: 0 0 auto;height: auto;line-height: 1;align-self: flex-start;\">\n<section style=\"text-align: justify;\">\n<p style=\"text-wrap: wrap;\"><br  \/><\/p>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: top;width: 90%;flex: 0 0 auto;height: auto;padding-left: 8px;align-self: flex-start;\">\n<section style=\"color: rgb(106, 106, 106);font-size: 15px;text-align: left;\">\n<p style=\"text-align: justify;text-wrap: wrap;\"><span style=\"color: rgb(203, 47, 21);\">\u56fe 2.5.4:&nbsp;<\/span><span style=\"text-align: left;\">\u8f6c\u57fa\u56e0\u5c0f\u9f20\u548c\u679c\u8747\u7684\u751f\u6210\u3002<\/span><\/p>\n<p>\u5728\u6b64\uff0c\u6ce8\u5c04\u5230\u5c0f\u9f20\u4f53\u5185\u7684\u57fa\u56e0\u4f1a\u5f15\u8d77\u6bdb\u8272\u7684\u53d8\u5316\uff0c\u800c\u6ce8\u5c04\u5230\u679c\u8747\u4f53\u5185\u7684\u57fa\u56e0\u5219\u4f1a\u5f15\u8d77\u773c\u775b\u989c\u8272\u7684\u53d8\u5316\u3002\u5728\u8fd9\u4e24\u79cd\u7269\u79cd\u7684\u4e00\u4e9b\u8f6c\u57fa\u56e0\u52a8\u7269\u4e2d\uff0cDNA \u88ab\u63d2\u5165\u5230\u4e0d\u540c\u7ec6\u80de\u7684\u4e0d\u540c\u67d3\u8272\u4f53\u4f4d\u70b9\uff08\u89c1\u5e95\u90e8\u63d2\u56fe\uff09<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin-top: 10px;margin-bottom: 10px;\">\n<section style=\"display: inline-block;width: 100%;border-width: 2px;border-style: dashed;border-color: rgb(164, 172, 181);padding: 10px;background-color: rgb(238, 249, 255);border-radius: 11.2px;overflow: hidden;\">\n<section style=\"color: rgb(0, 0, 0);\">\n<p style=\"text-wrap: wrap;\">\u672c\u6cfd\u7684\u56e2\u961f\u7b5b\u9009\u4e86\u6570\u5343\u53ea\u7a81\u53d8\u679c\u8747\uff0c\u5bfb\u627e\u90a3\u4e9b\u7531\u4e8e\u57fa\u56e0\u7a81\u53d8\u800c\u65e0\u6cd5\u9075\u5faa\u663c\u591c\u8282\u5f8b\u7684\u7f55\u89c1\u4e2a\u4f53\u3002\u8fd9\u9879\u7814\u7a76\u9996\u6b21\u63ed\u793a\u4e86\u751f\u7269\u949f\u7684\u5206\u5b50\u673a\u5236\u3002\u5468\u671f\uff08<em>per<\/em>\uff09\u57fa\u56e0\u7684\u7a81\u53d8\u5f71\u54cd\u4e86\u679c\u8747\u5185\u90e8\u65f6\u949f\u7684\u6240\u6709\u663c\u591c\u8282\u5f8b\u884c\u4e3a\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin-top: 10px;margin-bottom: 10px;\">\n<section style=\"display: inline-block;width: 100%;border-width: 2px;border-style: dashed;border-color: rgb(164, 172, 181);padding: 10px;background-color: rgb(238, 249, 255);border-radius: 11.2px;overflow: hidden;\">\n<section style=\"color: rgb(0, 0, 0);\">\n<p style=\"text-wrap: wrap;\">\u6709\u8da3\u7684\u662f\uff0cper\u57fa\u56e0\u7a81\u53d8\u53ef\u4ee5\u901a\u8fc7\u591a\u79cd\u65b9\u5f0f\u6539\u53d8\u751f\u7269\u949f\uff08\u89c1<span style=\"color: rgb(203, 47, 21);\">\u56fe2.5.5<\/span>\uff09\u3002\u65e0\u8282\u5f8b\u7a81\u53d8\u7684\u679c\u8747\u5728\u4efb\u4f55\u884c\u4e3a\u4e2d\u90fd\u6ca1\u6709\u8868\u73b0\u51fa\u660e\u663e\u7684\u5185\u5728\u8282\u5f8b\uff0c\u8fd9\u8868\u660eper\u57fa\u56e0\u5bf9\u8282\u5f8b\u884c\u4e3a\u81f3\u5173\u91cd\u8981\u3002\u90a3\u4e9b\u4ecd\u4fdd\u7559\u90e8\u5206\u57fa\u56e0\u529f\u80fd\u7684\u7a81\u53d8\u4f1a\u5bfc\u81f4\u5f02\u5e38\u7684\u8282\u5f8b\uff0c\u4f8b\u5982\u957f\u65e5\u7b49\u4f4d\u57fa\u56e0\u5bfc\u81f428\u5c0f\u65f6\u7684\u5468\u671f\uff0c\u800c\u77ed\u65e5\u7b49\u4f4d\u57fa\u56e0\u5219\u4ea7\u751f19\u5c0f\u65f6\u7684\u5468\u671f\u3002\u56e0\u6b64\uff0cper\u57fa\u56e0\u4e0d\u4ec5\u662f\u65f6\u949f\u7684\u5173\u952e\u7ec4\u6210\u90e8\u5206\uff0c\u5b83\u8fd8\u50cf\u4e00\u4e2a\u8ba1\u65f6\u5668\uff0c\u8c03\u63a7\u7740\u65f6\u949f\u7684\u8fd0\u884c\u901f\u5ea6\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin-top: 10px;margin-bottom: 10px;\">\n<section style=\"display: inline-block;width: 100%;border-width: 2px;border-style: dashed;border-color: rgb(164, 172, 181);padding: 10px;background-color: rgb(238, 249, 255);border-radius: 11.2px;overflow: hidden;\">\n<section style=\"color: rgb(0, 0, 0);\">\n<p style=\"text-wrap: wrap;\">\u66f4\u4e3a\u91cd\u8981\u7684\u662f\uff0cper\u57fa\u56e0\u7a81\u53d8\u4f53\u9664\u4e86\u663c\u591c\u8282\u5f8b\u884c\u4e3a\u7684\u6539\u53d8\u5916\uff0c\u5e76\u6ca1\u6709\u8868\u73b0\u51fa\u5176\u4ed6\u663e\u8457\u7684\u4e0d\u5229\u5f71\u54cd\u3002\u8fd9\u4e00\u53d1\u73b0\u975e\u5e38\u91cd\u8981\uff0c\u56e0\u4e3a\u5728\u6b64\u4e4b\u524d\uff0c\u8bb8\u591a\u4eba\u8d28\u7591\u662f\u5426\u5b58\u5728\u4ec5\u5f71\u54cd\u884c\u4e3a\u800c\u4e0d\u5f71\u54cd\u52a8\u7269\u751f\u7406\u7684\u201c\u884c\u4e3a\u57fa\u56e0\u201d\u3002per\u57fa\u56e0\u663e\u7136\u5c31\u662f\u8fd9\u6837\u4e00\u79cd\u201c\u884c\u4e3a\u57fa\u56e0\u201d\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin-top: 10px;margin-bottom: 10px;\">\n<section style=\"display: inline-block;width: 100%;border-width: 2px;border-style: dashed;border-color: rgb(164, 172, 181);padding: 10px;background-color: rgb(238, 249, 255);border-radius: 11.2px;overflow: hidden;\">\n<section style=\"color: rgb(0, 0, 0);\">\n<p style=\"text-wrap: 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style=\"text-wrap: wrap;\">\u5728\u679c\u8747\u548c\u5c0f\u9f20\u4e2d\uff0c\u65f6\u949f\u86cb\u767d\u90fd\u5145\u5f53\u8f6c\u5f55\u6fc0\u6d3b\u56e0\u5b50\u3002\u5b83\u4e0e\u4e00\u4e2a\u4f34\u4fa3\u86cb\u767d\u4e00\u8d77\u63a7\u5236\u7740\u51b3\u5b9a\u884c\u4e3a\uff08\u5982\u6d3b\u52a8\u6c34\u5e73\uff09\u7684\u57fa\u56e0\u8f6c\u5f55\u3002\u65f6\u949f\u86cb\u767d\u53ca\u5176\u4f19\u4f34\u8fd8\u523a\u6fc0\u8282\u5f8b\u57fa\u56e0\u7684\u8f6c\u5f55\u3002\u7136\u800c\uff0c\u5468\u671f\u86cb\u767d\u4f1a\u6291\u5236\u65f6\u949f\u86cb\u767d\u5bf9\u8282\u5f8b\u57fa\u56e0\u8868\u8fbe\u7684\u6fc0\u6d3b\u4f5c\u7528\uff0c\u56e0\u6b64\u968f\u7740\u5468\u671f\u86cb\u767d\u7684\u79ef\u7d2f\uff0c\u8282\u5f8b\u57fa\u56e0\u7684\u8f6c\u5f55\u9010\u6e10\u51cf\u5c11\uff08\u89c1<span style=\"color: rgb(203, 47, 21);\">\u56fe2.5.7<\/span>\uff09\u300224\u5c0f\u65f6\u5468\u671f\u7684\u5f62\u6210\u662f\u56e0\u4e3a\u5468\u671f\u86cb\u767d\u7684\u79ef\u7d2f\u548c\u6fc0\u6d3b\u5728\u8282\u5f8b\u57fa\u56e0\u8f6c\u5f55\u540e\u5ef6\u8fdf\u4e86\u6570\u5c0f\u65f6\uff0c\u8fd9\u4e00\u8fc7\u7a0b\u53d7\u5468\u671f\u86cb\u767d\u7684\u78f7\u9178\u5316\u3001\u4e0d\u7a33\u5b9a\u6027\u53ca\u5176\u4e0e\u5176\u4ed6\u5faa\u73af\u86cb\u767d\u7684\u76f8\u4e92\u4f5c\u7528\u6240\u8c03\u63a7\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin-top: 10px;margin-bottom: 10px;\">\n<section style=\"display: inline-block;width: 100%;border-width: 2px;border-style: dashed;border-color: rgb(164, 172, 181);padding: 10px;background-color: rgb(238, 249, 255);border-radius: 11.2px;overflow: hidden;\">\n<section style=\"color: rgb(0, 0, 0);\">\n<p style=\"text-wrap: wrap;\">\u8282\u5f8b\u57fa\u56e0\u3001\u65f6\u949f\u57fa\u56e0\u53ca\u5176\u76f8\u5173\u57fa\u56e0\u7684\u5206\u5b50\u7279\u6027\u4e3a\u663c\u591c\u8282\u5f8b\u63d0\u4f9b\u4e86\u6240\u6709\u5fc5\u8981\u7684\u529f\u80fd\uff1a<\/p>\n<p style=\"text-wrap: wrap;\">1. \u663c\u591c\u8282\u5f8b\u57fa\u56e0\u7684\u8f6c\u5f55\u968f\u774024\u5c0f\u65f6\u7684\u5468\u671f\u800c\u53d8\u5316\uff1a\u591c\u95f4\u5468\u671f\u86cb\u767d\u6d3b\u6027\u8f83\u9ad8\uff0c\u800c\u65f6\u949f\u86cb\u767d\u5728\u767d\u5929\u7684\u6d3b\u6027\u8f83\u9ad8\u3002<\/p>\n<p style=\"text-wrap: wrap;\">2. \u663c\u591c\u8282\u5f8b\u57fa\u56e0\u662f\u76f8\u4e92\u4f5c\u7528\u7684\u8f6c\u5f55\u56e0\u5b50\uff0c\u5b83\u4eec\u901a\u8fc7\u8c03\u8282\u4fe1\u4f7fRNA\u6c34\u5e73\u4ea7\u751f\u632f\u8361\u3002\u65f6\u949f\u86cb\u767d\u6fc0\u6d3b\u8f6c\u5f55\uff0c\u800c\u5468\u671f\u86cb\u767d\u5219\u6291\u5236\u65f6\u949f\u86cb\u767d\u7684\u529f\u80fd\u3002<\/p>\n<p style=\"text-wrap: wrap;\">3. \u663c\u591c\u8282\u5f8b\u57fa\u56e0\u8fd8\u8c03\u63a7\u5176\u4ed6\u57fa\u56e0\u7684\u8f6c\u5f55\uff0c\u8fd9\u4e9b\u57fa\u56e0\u968f\u540e\u5f71\u54cd\u591a\u79cd\u4e0b\u6e38\u53cd\u5e94\u3002\u4f8b\u5982\uff0c\u5728\u679c\u8747\u4e2d\uff0c\u795e\u7ecf\u80bd\u57fa\u56e0\u63a7\u5236\u7740\u8fd0\u52a8\u6d3b\u52a8\u6c34\u5e73\u3002<\/p>\n<p style=\"text-wrap: wrap;\">4. \u8fd9\u4e9b\u57fa\u56e0\u7684\u632f\u8361\u53ef\u4ee5\u901a\u8fc7\u5149\u7167\u6765\u91cd\u7f6e\u3002<\/p>\n<p style=\"text-wrap: wrap;\">2017\u5e74\uff0c\u6770\u5f17\u91cc\u00b7\u970d\u5c14\u3001\u8fc8\u514b\u5c14\u00b7\u7f57\u65af\u5df4\u4ec0\u548c\u8fc8\u514b\u5c14\u00b7\u6768\u56e0\u5bf9\u8fd9\u4e00\u5206\u5b50\u65f6\u949f\u673a\u5236\u7684\u8be6\u7ec6\u9610\u91ca\u800c\u83b7\u5f97\u8bfa\u8d1d\u5c14\u751f\u7406\u5b66\u6216\u533b\u5b66\u5956\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-imgfileid=\"308774072\" data-ratio=\"1.3042671614100185\" data-s=\"300,640\"  data-type=\"png\" data-w=\"539\" style=\"vertical-align: middle;width: 100%;\" src=\"http:\/\/dh.oncolab.cn\/wp-content\/uploads\/2025\/01\/wxsync-2025-01-47065328cc688db88cebbf5bf8dc696b.png\"  \/><\/section>\n<\/section>\n<section style=\"text-align: right;justify-content: flex-end;margin-right: 0%;margin-bottom: 10px;margin-left: 0%;display: flex;flex-flow: row;\">\n<section style=\"display: inline-block;vertical-align: top;width: 30px;border-left: 2px solid rgb(51, 122, 183);border-bottom-left-radius: 0px;border-bottom: 2px solid rgb(51, 122, 183);border-bottom-right-radius: 0px;flex: 0 0 auto;height: auto;line-height: 1;align-self: flex-start;\">\n<section style=\"text-align: justify;\">\n<p style=\"text-wrap: wrap;\"><br  \/><\/p>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: top;width: 90%;flex: 0 0 auto;height: auto;padding-left: 8px;align-self: flex-start;\">\n<section style=\"color: rgb(106, 106, 106);font-size: 15px;text-align: left;\">\n<p style=\"text-align: justify;text-wrap: wrap;\"><span style=\"color: rgb(203, 47, 21);\">\u56fe 2.5.5\uff1a<\/span><span style=\"text-align: left;\">\u5355\u4e2a\u57fa\u56e0\u63a7\u5236\u679c\u8747\u884c\u4e3a\u7684\u663c\u591c\u8282\u5f8b\u3002per \u57fa\u56e0\u7684\u7a81\u53d8\u4f1a\u5f71\u54cd\u679c\u8747\u5185\u90e8\u751f\u7269\u949f\u8c03\u8282\u7684\u6240\u6709\u663c\u591c\u8282\u5f8b\u884c\u4e3a\u3002<\/span><\/p>\n<p>A. \u6b63\u5e38\u679c\u8747\u548cper \u57fa\u56e0\u7a81\u53d8\u4f53\uff08\u77ed\u65e5\u7167\u3001\u957f\u65e5\u7167\u548c\u65e0\u8282\u5f8b\uff09\u4e09\u79cd\u54c1\u7cfb\u7684\u6d3b\u52a8\u8282\u5f8b\u3002\u5728\u5c06\u679c\u8747\u4ece12\u5c0f\u65f6\u5149\u7167\u548c12\u5c0f\u65f6\u9ed1\u6697\u7684\u5faa\u73af\u73af\u5883\u8f6c\u79fb\u5230\u6301\u7eed\u9ed1\u6697\u540e\uff0c\u901a\u8fc7\u7ea2\u5916\u5149\u76d1\u6d4b\u5b83\u4eec\u7684\u6d3b\u52a8\u3002\u8bb0\u5f55\u4e2d\u7684\u7c97\u7ebf\u6bb5\u8868\u793a\u6d3b\u52a8\u3002<\/p>\n<p>B. \u6b63\u5e38\u6210\u5e74\u679c\u8747\u7fa4\u4f53\u4ee5\u5468\u671f\u6027\u7684\u65b9\u5f0f\u4ece\u86f9\u58f3\u4e2d\u51fa\u73b0\uff0c\u5373\u4f7f\u5728\u6301\u7eed\u9ed1\u6697\u4e2d\u4e5f\u662f\u5982\u6b64\u3002\u56fe\u4e2d\u663e\u793a\u4e86\u5728\u6301\u7eed\u9ed1\u6697\u76844\u5929\u671f\u95f4\uff0c\u6bcf\u5c0f\u65f6\u51fa\u73b0\u7684\u679c\u8747\u6570\u91cf\uff08\u6765\u81ea\u56db\u4e2a\u4e0d\u540c\u7fa4\u4f53\uff09\u3002\u65e0\u8282\u5f8b\u7a81\u53d8\u4f53\u7fa4\u4f53\u5728\u9ed1\u6697\u4e2d\u6ca1\u6709\u8868\u73b0\u51fa\u53ef\u8fa8\u522b\u7684\u8282\u5f8b\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-imgfileid=\"308774074\" data-ratio=\"1.1813880126182965\" data-s=\"300,640\"  data-type=\"png\" data-w=\"634\" style=\"vertical-align: middle;width: 100%;\" src=\"http:\/\/dh.oncolab.cn\/wp-content\/uploads\/2025\/01\/wxsync-2025-01-2911f5035d4216592cbd1e900d1fa210.png\"  \/><\/section>\n<\/section>\n<section style=\"text-align: right;justify-content: flex-end;margin-right: 0%;margin-bottom: 10px;margin-left: 0%;display: flex;flex-flow: row;\">\n<section style=\"display: inline-block;vertical-align: top;width: 30px;border-left: 2px solid rgb(51, 122, 183);border-bottom-left-radius: 0px;border-bottom: 2px solid rgb(51, 122, 183);border-bottom-right-radius: 0px;flex: 0 0 auto;height: auto;line-height: 1;align-self: flex-start;\">\n<section style=\"text-align: justify;\">\n<p style=\"text-wrap: wrap;\"><br  \/><\/p>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: top;width: 90%;flex: 0 0 auto;height: auto;padding-left: 8px;align-self: flex-start;\">\n<section style=\"color: rgb(106, 106, 106);font-size: 15px;text-align: left;\">\n<p style=\"text-align: justify;text-wrap: wrap;\"><span style=\"color: rgb(203, 47, 21);\">\u56fe 2.5.6\uff1a<\/span><span style=\"text-align: left;\">\u65f6\u949f\u57fa\u56e0\u5bf9\u5c0f\u9f20\u663c\u591c\u8282\u5f8b\u7684\u8c03\u63a7\u3002\u8bb0\u5f55\u663e\u793a\u4e86\u4e09\u79cd\u7c7b\u578b\u5c0f\u9f20\u7684\u6d3b\u52a8\u5468\u671f\uff1a\u91ce\u751f\u578b\u3001\u6742\u5408\u578b\u548c\u7eaf\u5408\u578b\u3002\u6240\u6709\u5c0f\u9f20\u5728\u524d7\u5929\u7ecf\u538612\u5c0f\u65f6\u7684\u5149\u6697\u5faa\u73af\uff0c\u7136\u540e\u8f6c\u79fb\u5230\u6301\u7eed\u9ed1\u6697\u7684\u73af\u5883\u4e2d\u3002\u4e4b\u540e\uff0c\u5b83\u4eec\u88ab\u66b4\u9732\u57286\u5c0f\u65f6\u7684\u5149\u7167\u5468\u671f\u4e2d\uff0c\u4ee5\u91cd\u7f6e\u5176\u8282\u5f8b\u3002\u91ce\u751f\u578b\u5c0f\u9f20\u7684\u663c\u591c\u8282\u5f8b\u5468\u671f\u4e3a23.1\u5c0f\u65f6\u3002\u6742\u5408\u578b\u65f6\u949f\u57fa\u56e0\u5c0f\u9f20\u7684\u5468\u671f\u4e3a24.9\u5c0f\u65f6\uff0c\u800c\u7eaf\u5408\u578b\u65f6\u949f\u57fa\u56e0\u5c0f\u9f20\u5728\u8f6c\u79fb\u5230\u6301\u7eed\u9ed1\u6697\u65f6\u5b8c\u5168\u4e27\u5931\u4e86\u663c\u591c\u8282\u5f8b\uff0c\u5e76\u5728\u5149\u7167\u671f\u540e\u77ed\u6682\u8868\u73b0\u51fa28.4\u5c0f\u65f6\u7684\u8282\u5f8b\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-imgfileid=\"308774073\" data-ratio=\"1.023842917251052\" data-s=\"300,640\"  data-type=\"png\" data-w=\"713\" style=\"vertical-align: middle;width: 100%;\" src=\"http:\/\/dh.oncolab.cn\/wp-content\/uploads\/2025\/01\/wxsync-2025-01-70d0663ed0a102edf8d8db1a4e79db13.png\"  \/><\/section>\n<\/section>\n<section style=\"text-align: right;justify-content: flex-end;margin-right: 0%;margin-bottom: 10px;margin-left: 0%;display: flex;flex-flow: row;\">\n<section style=\"display: inline-block;vertical-align: top;width: 30px;border-left: 2px solid rgb(51, 122, 183);border-bottom-left-radius: 0px;border-bottom: 2px solid rgb(51, 122, 183);border-bottom-right-radius: 0px;flex: 0 0 auto;height: auto;line-height: 1;align-self: flex-start;\">\n<section style=\"text-align: justify;\">\n<p style=\"text-wrap: wrap;\"><br  \/><\/p>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: top;width: 90%;flex: 0 0 auto;height: auto;padding-left: 8px;align-self: flex-start;\">\n<section style=\"color: rgb(106, 106, 106);font-size: 15px;text-align: left;\">\n<p style=\"text-align: justify;text-wrap: wrap;\"><span style=\"color: rgb(203, 47, 21);\">\u56fe 2.5.7\uff1a<\/span><span style=\"text-align: left;\">\u9a71\u52a8\u663c\u591c\u8282\u5f8b\u7684\u5206\u5b50\u673a\u5236\u3002\u751f\u7269\u949f\u57fa\u56e0\u53d7\u4e24\u79cd\u6838\u86cb\u767d\u2014\u2014\u5468\u671f\u86cb\u767d\uff08PER\uff09\u548c\u65e0\u8282\u5f8b\u86cb\u767d\uff08TIM\uff09\u7684\u8c03\u8282\u3002\u8fd9\u4e9b\u86cb\u767d\u8d28\u9010\u6e10\u79ef\u7d2f\uff0c\u5e76\u76f8\u4e92\u7ed3\u5408\u5f62\u6210\u4e8c\u805a\u4f53\u3002\u4e00\u65e6\u5f62\u6210\u4e8c\u805a\u4f53\uff0c\u5b83\u4eec\u4fbf\u8fdb\u5165\u7ec6\u80de\u6838\u5e76\u5173\u95ed\u5305\u62ec\u5b83\u4eec\u81ea\u8eab\u5728\u5185\u7684\u663c\u591c\u8282\u5f8b\u57fa\u56e0\u7684\u8868\u8fbe\u3002\u8fd9\u4e00\u8fc7\u7a0b\u901a\u8fc7\u6291\u5236\u65f6\u949f\u86cb\u767d\uff08CLOCK\uff09\u548cCYCLE\u86cb\u767d\u7684\u4f5c\u7528\u6765\u5b9e\u73b0\uff0c\u5b83\u4eec\u662f\u9a71\u52a8\u8282\u5f8b\u57fa\u56e0\u548c\u65e0\u8282\u5f8b\u57fa\u56e0\u8f6c\u5f55\u7684\u5173\u952e\u56e0\u5b50\u3002\u5468\u671f\u86cb\u767d\u975e\u5e38\u4e0d\u7a33\u5b9a\uff0c\u5927\u90e8\u5206\u5728\u964d\u89e3\u524d\u672a\u80fd\u6291\u5236\u7531\u65f6\u949f\u86cb\u767d\u4ecb\u5bfc\u7684\u57fa\u56e0\u8f6c\u5f55\u3002\u5468\u671f\u86cb\u767d\u7684\u964d\u89e3\u7531\u591a\u79cd\u86cb\u767d\u6fc0\u9176\u901a\u8fc7\u78f7\u9178\u5316\u4e8b\u4ef6\u8c03\u63a7\u3002\u5f53\u5468\u671f\u86cb\u767d\u4e0e\u65e0\u8282\u5f8b\u86cb\u767d\u7ed3\u5408\u65f6\uff0c\u5b83\u4eec\u76f8\u4e92\u4fdd\u62a4\uff0c\u907f\u514d\u964d\u89e3\u3002\u968f\u7740\u65f6\u949f\u86cb\u767d\u9a71\u52a8\u66f4\u591a\u8282\u5f8b\u57fa\u56e0\u548c\u65e0\u8282\u5f8b\u57fa\u56e0\u7684\u8868\u8fbe\uff0c\u8db3\u591f\u7684\u5468\u671f\u86cb\u767d\u548c\u65e0\u8282\u5f8b\u86cb\u767d\u6700\u7ec8\u79ef\u7d2f\u5e76\u5f62\u6210\u7a33\u5b9a\u7684\u4e8c\u805a\u4f53\uff0c\u8fdb\u5165\u7ec6\u80de\u6838\u6291\u5236\u5b83\u4eec\u81ea\u8eab\u7684\u8f6c\u5f55\u3002\u7ed3\u679c\uff0c\u8282\u5f8b\u57fa\u56e0\u548c\u65e0\u8282\u5f8b\u57fa\u56e0\u7684mRNA\u6c34\u5e73\u4e0b\u964d\uff1b\u968f\u540e\uff0c\u5468\u671f\u86cb\u767d\u548c\u65e0\u8282\u5f8b\u86cb\u767d\u7684\u6c34\u5e73\u4e5f\u4e0b\u964d\uff0c\u65f6\u949f\u86cb\u767d\u53ef\u4ee5\u518d\u6b21\u9a71\u52a8\u8282\u5f8b\u57fa\u56e0\u548c\u65e0\u8282\u5f8b\u57fa\u56e0\u7684\u8868\u8fbe\u3002\u5728\u767d\u5929\uff0c\u65e0\u8282\u5f8b\u86cb\u767d\u901a\u8fc7\u5149\u8c03\u8282\u4fe1\u53f7\u901a\u8def\uff08\u5305\u62ec\u9690\u82b1\u8272\u7d20\uff09\u964d\u89e3\uff0c\u56e0\u6b64\u5468\u671f\u86cb\u767d\/\u65e0\u8282\u5f8b\u86cb\u767d\u590d\u5408\u7269\u53ea\u5728\u591c\u95f4\u5f62\u6210\u3002\u65f6\u949f\u86cb\u767d\u8bf1\u5bfc\u5468\u671f\u86cb\u767d\u548c\u65e0\u8282\u5f8b\u86cb\u767d\u7684\u8868\u8fbe\uff0c\u4f46\u8fd9\u4e9b\u86cb\u767d\u8d28\u968f\u540e\u4f1a\u6291\u5236\u65f6\u949f\u86cb\u767d\u7684\u529f\u80fd\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin-top: 10px;margin-bottom: 10px;\">\n<section style=\"display: inline-block;width: 100%;border-width: 2px;border-style: dashed;border-color: rgb(164, 172, 181);padding: 10px;background-color: rgb(238, 249, 255);border-radius: 11.2px;overflow: hidden;\">\n<section style=\"color: rgb(0, 0, 0);\">\n<p style=\"text-wrap: wrap;\">\u76f8\u540c\u7684\u9057\u4f20\u7f51\u7edc\u4e5f\u63a7\u5236\u7740\u4eba\u7c7b\u7684\u663c\u591c\u8282\u5f8b\u3002\u60a3\u6709\u665a\u671f\u7761\u7720\u76f8\u4f4d\u7efc\u5408\u75c7\u7684\u4eba\u901a\u5e38\u6709\u8f83\u77ed\u768420\u5c0f\u65f6\u5468\u671f\uff0c\u5e76\u8868\u73b0\u51fa\u6781\u7aef\u65e9\u7761\u65e9\u8d77\u7684\u201c\u6668\u578b\u4eba\u201d\u7279\u5f81\u3002\u8def\u6613\u65af\u00b7\u666e\u5854\u5207\u514b\u548c\u5085\u9896\u6167\u53d1\u73b0\uff0c\u8fd9\u4e9b\u4e2a\u4f53\u5728\u4eba\u7c7bper\u57fa\u56e0\u4e0a\u5b58\u5728\u7a81\u53d8\u3002\u8fd9\u4e9b\u7814\u7a76\u7ed3\u679c\u8868\u660e\uff0c\u4ece\u6606\u866b\u5230\u4eba\u7c7b\uff0c\u884c\u4e3a\u57fa\u56e0\u5728\u8fdb\u5316\u4e0a\u662f\u4fdd\u5b88\u7684\u3002\u665a\u671f\u7761\u7720\u76f8\u4f4d\u7efc\u5408\u75c7\u5728\u7b2c44\u7ae0\u7684\u7761\u7720\u90e8\u5206\u8fdb\u884c\u4e86\u8be6\u7ec6\u8ba8\u8bba\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"color: rgb(203, 47, 21);line-height: 1.5;\">\n<p style=\"text-wrap: wrap;\"><strong>2.5.2 \u86cb\u767d\u6fc0\u9176\u7684\u81ea\u7136\u53d8\u5f02\u8c03\u8282\u679c\u8747\u548c\u871c\u8702\u7684\u6d3b\u52a8<\/strong><\/p>\n<\/section>\n<section style=\"margin-top: 10px;margin-bottom: 10px;\">\n<section style=\"display: inline-block;width: 100%;border-width: 2px;border-style: dashed;border-color: rgb(164, 172, 181);padding: 10px;background-color: rgb(238, 249, 255);border-radius: 11.2px;overflow: hidden;\">\n<section style=\"color: rgb(0, 0, 0);\">\n<p style=\"text-wrap: wrap;\">\u5728\u524d\u9762\u63cf\u8ff0\u7684\u663c\u591c\u8282\u5f8b\u7814\u7a76\u4e2d\uff0c\u79d1\u5b66\u5bb6\u4eec\u901a\u8fc7\u968f\u673a\u8bf1\u53d8\u6765\u8bc6\u522b\u4e0e\u751f\u7269\u8fc7\u7a0b\u76f8\u5173\u7684\u57fa\u56e0\u3002\u6240\u6709\u6b63\u5e38\u4e2a\u4f53\u90fd\u5177\u6709\u529f\u80fd\u6027\u7684\u8282\u5f8b\u57fa\u56e0\u3001\u65f6\u949f\u57fa\u56e0\u548c\u76f8\u5173\u57fa\u56e0\uff1b\u800c\u53ea\u6709\u5728\u8bf1\u53d8\u5904\u7406\u540e\uff0c\u624d\u4f1a\u4ea7\u751f\u4e0d\u540c\u7684\u7b49\u4f4d\u57fa\u56e0\u3002\u7136\u800c\uff0c\u53e6\u4e00\u4e2a\u66f4\u5fae\u5999\u7684\u95ee\u9898\u662f\uff0c\u54ea\u4e9b\u9057\u4f20\u53d8\u5316\u53ef\u80fd\u5bfc\u81f4\u6b63\u5e38\u4e2a\u4f53\u95f4\u7684\u884c\u4e3a\u5dee\u5f02\u3002\u739b\u5c14\u62c9\u00b7\u7d22\u79d1\u6d1b\u592b\u65af\u57fa\u53ca\u5176\u540c\u4e8b\u7684\u7814\u7a76\u9996\u6b21\u9274\u5b9a\u51fa\u4e86\u4e0e\u81ea\u7136\u4e2a\u4f53\u884c\u4e3a\u5dee\u5f02\u76f8\u5173\u7684\u57fa\u56e0\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin-top: 10px;margin-bottom: 10px;\">\n<section style=\"display: inline-block;width: 100%;border-width: 2px;border-style: dashed;border-color: rgb(164, 172, 181);padding: 10px;background-color: rgb(238, 249, 255);border-radius: 11.2px;overflow: hidden;\">\n<section style=\"color: rgb(0, 0, 0);\">\n<p style=\"text-wrap: wrap;\">\u679c\u8747\u5e7c\u866b\u5728\u6d3b\u52a8\u6c34\u5e73\u548c\u8fd0\u52a8\u65b9\u5f0f\u4e0a\u5b58\u5728\u5dee\u5f02\u3002\u4e00\u4e9b\u5e7c\u866b\u88ab\u79f0\u4e3a\u201c\u6f2b\u6e38\u8005\u201d\uff0c\u5b83\u4eec\u4f1a\u957f\u8ddd\u79bb\u79fb\u52a8\uff08\u89c1<span style=\"color: rgb(203, 47, 21);\">\u56fe2.5.8<\/span>\uff09\uff0c\u800c\u53e6\u4e00\u4e9b\u5e7c\u866b\u5219\u88ab\u79f0\u4e3a\u201c\u5b88\u5bb6\u8005\u201d\uff0c\u5b83\u4eec\u76f8\u5bf9\u9759\u6b62\u3002\u91ce\u5916\u5206\u79bb\u7684\u679c\u8747\u5e7c\u866b\u53ef\u80fd\u662f\u201c\u6f2b\u6e38\u8005\u201d\u6216\u201c\u5b88\u5bb6\u8005\u201d\uff0c\u8fd9\u8868\u660e\u8fd9\u4e9b\u5dee\u5f02\u662f\u81ea\u7136\u53d8\u5f02\u7684\u7ed3\u679c\uff0c\u800c\u975e\u5b9e\u9a8c\u5ba4\u8bf1\u5bfc\u7684\u7a81\u53d8\u3002\u8fd9\u4e9b\u7279\u5f81\u662f\u53ef\u9057\u4f20\u7684\uff1b\u201c\u6f2b\u6e38\u8005\u201d\u7236\u6bcd\u7684\u540e\u4ee3\u5927\u591a\u662f\u201c\u6f2b\u6e38\u8005\u201d\uff0c\u201c\u5b88\u5bb6\u8005\u201d\u7236\u6bcd\u7684\u540e\u4ee3\u5927\u591a\u662f\u201c\u5b88\u5bb6\u8005\u201d\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-imgfileid=\"308774076\" data-ratio=\"0.5324074074074074\" data-s=\"300,640\"  data-type=\"png\" data-w=\"1080\" style=\"vertical-align: middle;width: 100%;\" src=\"http:\/\/dh.oncolab.cn\/wp-content\/uploads\/2025\/01\/wxsync-2025-01-cfc85383f8b4677c284aedc9ba64ce1f.png\"  \/><\/section>\n<\/section>\n<section style=\"text-align: right;justify-content: flex-end;margin-right: 0%;margin-bottom: 10px;margin-left: 0%;display: flex;flex-flow: row;\">\n<section style=\"display: inline-block;vertical-align: top;width: 30px;border-left: 2px solid rgb(51, 122, 183);border-bottom-left-radius: 0px;border-bottom: 2px solid rgb(51, 122, 183);border-bottom-right-radius: 0px;flex: 0 0 auto;height: auto;line-height: 1;align-self: flex-start;\">\n<section style=\"text-align: justify;\">\n<p style=\"text-wrap: wrap;\"><br  \/><\/p>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: top;width: 90%;flex: 0 0 auto;height: auto;padding-left: 8px;align-self: flex-start;\">\n<section style=\"color: rgb(106, 106, 106);font-size: 15px;text-align: left;\">\n<p style=\"text-align: justify;text-wrap: wrap;\"><span style=\"color: rgb(203, 47, 21);\">\u56fe 2.5.8\uff1a<\/span><span style=\"text-align: left;\">\u7d22\u79d1\u6d1b\u592b\u65af\u57fa\u901a\u8fc7\u4e0d\u540c\u91ce\u751f\u679c\u8747\u7684\u6742\u4ea4\u5b9e\u9a8c\uff0c\u7814\u7a76\u4e86\u201c\u6f2b\u6e38\u8005\u201d\u548c\u201c\u5b88\u5bb6\u8005\u201d\u5e7c\u866b\u4e4b\u95f4\u7684\u9057\u4f20\u5dee\u5f02\u3002\u7ed3\u679c\u8868\u660e\uff0c\u8fd9\u79cd\u5dee\u5f02\u4e3b\u8981\u7531\u4e00\u4e2a\u57fa\u56e0\u51b3\u5b9a\uff0c\u5373\u89c5\u98df\u57fa\u56e0\u5ea7\u3002\u89c5\u98df\u57fa\u56e0\u7f16\u7801\u4e00\u79cd\u4fe1\u53f7\u8f6c\u5bfc\u9176\uff0c\u8fd9\u79cd\u9176\u7531\u7ec6\u80de\u4ee3\u8c22\u7269\u73af\u9e1f\u82f7-3,5-\u5355\u78f7\u9178\uff08cGMP\uff09\u6fc0\u6d3b\u3002\u56e0\u6b64\uff0c\u8fd9\u79cd\u81ea\u7136\u884c\u4e3a\u5dee\u5f02\u6e90\u4e8e\u4fe1\u53f7\u8f6c\u5bfc\u9014\u5f84\u7684\u8c03\u63a7\u53d8\u5316\u3002\u8bb8\u591a\u795e\u7ecf\u5143\u529f\u80fd\u53d7\u86cb\u767d\u6fc0\u9176\u8c03\u8282\uff0c\u4f8b\u5982\u7531\u89c5\u98df\u57fa\u56e0\u7f16\u7801\u7684cGMP\u4f9d\u8d56\u6027\u6fc0\u9176\u3002\u50cf\u86cb\u767d\u6fc0\u9176\u8fd9\u6837\u7684\u5206\u5b50\u5728\u5c06\u77ed\u671f\u795e\u7ecf\u4fe1\u53f7\u8f6c\u5316\u4e3a\u795e\u7ecf\u5143\u6216\u795e\u7ecf\u56de\u8def\u7684\u957f\u671f\u7279\u6027\u53d8\u5316\u4e2d\u8d77\u7740\u5173\u952e\u4f5c\u7528\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin-top: 10px;margin-bottom: 10px;\">\n<section style=\"display: inline-block;width: 100%;border-width: 2px;border-style: dashed;border-color: rgb(164, 172, 181);padding: 10px;background-color: rgb(238, 249, 255);border-radius: 11.2px;overflow: hidden;\">\n<section style=\"color: rgb(0, 0, 0);\">\n<p style=\"text-wrap: wrap;\">\u4e3a\u4ec0\u4e48\u5728\u91ce\u751f\u679c\u8747\u79cd\u7fa4\u4e2d\u4fdd\u7559\u4e86\u8fd9\u79cd\u4fe1\u53f7\u9176\u7684\u53d8\u5f02\u6027\uff0c\u65e2\u6709\u201c\u6f2b\u6e38\u8005\u201d\u4e5f\u6709\u201c\u5b88\u5bb6\u8005\u201d\uff1f\u7b54\u6848\u5728\u4e8e\u73af\u5883\u53d8\u5316\u5e26\u6765\u7684\u9009\u62e9\u538b\u529b\u3002\u62e5\u6324\u7684\u73af\u5883\u6709\u5229\u4e8e\u201c\u6f2b\u6e38\u8005\u201d\u5e7c\u866b\uff0c\u5b83\u4eec\u80fd\u591f\u6bd4\u7ade\u4e89\u5bf9\u624b\u66f4\u6709\u6548\u5730\u79fb\u52a8\u5230\u65b0\u7684\u3001\u672a\u88ab\u5229\u7528\u7684\u98df\u7269\u6e90\uff1b\u800c\u5728\u7a00\u758f\u7684\u73af\u5883\u4e2d\uff0c\u201c\u5b88\u5bb6\u8005\u201d\u5e7c\u866b\u66f4\u5f7b\u5e95\u5730\u5229\u7528\u73b0\u6709\u98df\u7269\u6e90\uff0c\u56e0\u6b64\u66f4\u5177\u4f18\u52bf\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin-top: 10px;margin-bottom: 10px;\">\n<section style=\"display: inline-block;width: 100%;border-width: 2px;border-style: dashed;border-color: rgb(164, 172, 181);padding: 10px;background-color: rgb(238, 249, 255);border-radius: 11.2px;overflow: hidden;\">\n<section style=\"color: rgb(0, 0, 0);\">\n<p style=\"text-wrap: wrap;\">\u89c5\u98df\u57fa\u56e0\u4e5f\u5b58\u5728\u4e8e\u871c\u8702\u4e2d\u3002\u871c\u8702\u5728\u5176\u751f\u547d\u5468\u671f\u7684\u4e0d\u540c\u9636\u6bb5\u8868\u73b0\u51fa\u4e0d\u540c\u7684\u884c\u4e3a\uff1b\u901a\u5e38\uff0c\u5e74\u8f7b\u7684\u871c\u8702\u627f\u62c5\u62a4\u7406\u4efb\u52a1\uff0c\u800c\u5e74\u957f\u7684\u871c\u8702\u5219\u6210\u4e3a\u89c5\u98df\u8005\uff0c\u79bb\u5f00\u8702\u5de2\u3002\u89c5\u98df\u57fa\u56e0\u5728\u6d3b\u8dc3\u7684\u89c5\u98df\u871c\u8702\u5927\u8111\u4e2d\u9ad8\u5ea6\u8868\u8fbe\uff0c\u800c\u5728\u5e74\u8f7b\u4e14\u8f83\u5c11\u6d3b\u52a8\u7684\u62a4\u7406\u871c\u8702\u4e2d\u5219\u8868\u73b0\u8f83\u4f4e\u3002\u73af\u9e1f\u82f7-3,5-\u5355\u78f7\u9178\uff08cGMP\uff09\u4fe1\u53f7\u4f20\u5bfc\u5728\u5e74\u8f7b\u7684\u871c\u8702\u4e2d\u53ef\u80fd\u4fc3\u4f7f\u5b83\u4eec\u8fc7\u65e9\u8fdb\u5165\u89c5\u98df\u9636\u6bb5\uff0c\u8fd9\u79cd\u53d8\u5316\u53ef\u80fd\u7531\u73af\u5883\u523a\u6fc0\u6216\u871c\u8702\u7684\u5e74\u9f84\u589e\u957f\u5f15\u8d77\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin-top: 10px;margin-bottom: 10px;\">\n<section style=\"display: inline-block;width: 100%;border-width: 2px;border-style: dashed;border-color: rgb(164, 172, 181);padding: 10px;background-color: rgb(238, 249, 255);border-radius: 11.2px;overflow: hidden;\">\n<section style=\"color: rgb(0, 0, 0);\">\n<p style=\"text-wrap: wrap;\">\u56e0\u6b64\uff0c\u540c\u4e00\u4e2a\u57fa\u56e0\u4ee5\u4e0d\u540c\u65b9\u5f0f\u8c03\u63a7\u4e86\u4e24\u79cd\u4e0d\u540c\u6606\u866b\u7684\u884c\u4e3a\u53d8\u5f02\u3002\u5728\u679c\u8747\u4e2d\uff0c\u884c\u4e3a\u53d8\u5f02\u8868\u73b0\u4e3a\u4e0d\u540c\u4e2a\u4f53\u4e4b\u95f4\u7684\u5dee\u5f02\uff1b\u800c\u5728\u871c\u8702\u4e2d\uff0c\u8fd9\u79cd\u53d8\u5f02\u8868\u73b0\u4e3a\u540c\u4e00\u53ea\u871c\u8702\u5728\u4e0d\u540c\u5e74\u9f84\u9636\u6bb5\u7684\u884c\u4e3a\u5dee\u5f02\u3002\u8fd9\u79cd\u5dee\u5f02\u5c55\u793a\u4e86\u91cd\u8981\u7684\u8c03\u63a7\u57fa\u56e0\u5982\u4f55\u5728\u4e0d\u540c\u7269\u79cd\u7684\u4e0d\u540c\u884c\u4e3a\u7b56\u7565\u4e2d\u53d1\u6325\u4f5c\u7528\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"color: rgb(203, 47, 21);line-height: 1.5;\">\n<p style=\"text-wrap: wrap;\"><strong>2.5.3 \u795e\u7ecf\u80bd\u53d7\u4f53\u8c03\u8282\u51e0\u79cd\u7269\u79cd\u7684\u793e\u4f1a\u884c\u4e3a<\/strong><\/p>\n<\/section>\n<section style=\"margin-top: 10px;margin-bottom: 10px;\">\n<section style=\"display: inline-block;width: 100%;border-width: 2px;border-style: dashed;border-color: rgb(164, 172, 181);padding: 10px;background-color: rgb(238, 249, 255);border-radius: 11.2px;overflow: hidden;\">\n<section style=\"color: rgb(0, 0, 0);\">\n<p style=\"text-wrap: wrap;\">\u884c\u4e3a\u7684\u8bb8\u591a\u65b9\u9762\u90fd\u4e0e\u52a8\u7269\u4e0e\u5176\u4ed6\u52a8\u7269\u7684\u793e\u4f1a\u4e92\u52a8\u6709\u5173\u3002\u793e\u4f1a\u884c\u4e3a\u5728\u4e0d\u540c\u7269\u79cd\u95f4\u5dee\u5f02\u5f88\u5927\uff0c\u4f46\u5728\u4e00\u4e2a\u7269\u79cd\u5185\uff0c\u5b83\u5177\u6709\u5f88\u5927\u7684\u5148\u5929\u6210\u5206\uff0c\u8fd9\u90e8\u5206\u662f\u7531\u9057\u4f20\u63a7\u5236\u7684\u3002\u5728\u79c0\u4e3d\u9690\u6746\u7ebf\u866b\u8fd9\u79cd\u5706\u866b\u4e2d\uff0c\u7814\u7a76\u8005\u5206\u6790\u4e86\u4e00\u79cd\u7b80\u5355\u7684\u793e\u4f1a\u884c\u4e3a\u5f62\u5f0f\u3002\u8fd9\u4e9b\u52a8\u7269\u751f\u6d3b\u5728\u571f\u58e4\u4e2d\uff0c\u4ee5\u7ec6\u83cc\u4e3a\u98df\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin-top: 10px;margin-bottom: 10px;\">\n<section style=\"display: inline-block;width: 100%;border-width: 2px;border-style: dashed;border-color: rgb(164, 172, 181);padding: 10px;background-color: rgb(238, 249, 255);border-radius: 11.2px;overflow: hidden;\">\n<section style=\"color: rgb(0, 0, 0);\">\n<p style=\"text-wrap: wrap;\">\u4e0d\u540c\u7684\u91ce\u751f\u578b\u83cc\u682a\u5728\u8fdb\u98df\u884c\u4e3a\u4e0a\u8868\u73b0\u51fa\u663e\u8457\u5dee\u5f02\u3002\u6765\u81ea\u6807\u51c6\u5b9e\u9a8c\u5ba4\u682a\u7684\u52a8\u7269\u503e\u5411\u4e8e\u72ec\u5c45\uff0c\u5b83\u4eec\u5206\u6563\u5728\u7ec6\u83cc\u98df\u7269\u5f62\u6210\u7684\u8349\u576a\u4e0a\uff0c\u5e76\u4e14\u4e0d\u4e0e\u5f7c\u6b64\u4e92\u52a8\u3002\u800c\u5176\u4ed6\u682a\u7cfb\u7684\u52a8\u7269\u5219\u5c55\u73b0\u51fa\u7fa4\u5c45\u8fdb\u98df\u6a21\u5f0f\uff0c\u4f1a\u52a0\u5165\u7531\u6570\u5341\u6216\u6570\u767e\u53ea\u52a8\u7269\u7ec4\u6210\u7684\u5927\u578b\u8fdb\u98df\u7fa4\u4f53\uff08<span style=\"color: rgb(203, 47, 21);\">\u56fe2.5.9<\/span>\uff09\u3002\u8fd9\u4e9b\u682a\u7cfb\u4e4b\u95f4\u7684\u5dee\u5f02\u662f\u9057\u4f20\u7684\uff0c\u56e0\u4e3a\u8fd9\u4e24\u79cd\u8fdb\u98df\u6a21\u5f0f\u90fd\u662f\u7a33\u5b9a\u9057\u4f20\u7684\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-imgfileid=\"308774075\" data-ratio=\"0.4375\" data-s=\"300,640\"  data-type=\"png\" data-w=\"976\" style=\"vertical-align: middle;width: 100%;\" src=\"http:\/\/dh.oncolab.cn\/wp-content\/uploads\/2025\/01\/wxsync-2025-01-7d9299a309e738806c7fca0f3984cfac.png\"  \/><\/section>\n<\/section>\n<section style=\"text-align: right;justify-content: flex-end;margin-right: 0%;margin-bottom: 10px;margin-left: 0%;display: flex;flex-flow: row;\">\n<section style=\"display: inline-block;vertical-align: top;width: 30px;border-left: 2px solid rgb(51, 122, 183);border-bottom-left-radius: 0px;border-bottom: 2px solid rgb(51, 122, 183);border-bottom-right-radius: 0px;flex: 0 0 auto;height: auto;line-height: 1;align-self: flex-start;\">\n<section style=\"text-align: justify;\">\n<p style=\"text-wrap: wrap;\"><br  \/><\/p>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: top;width: 90%;flex: 0 0 auto;height: auto;padding-left: 8px;align-self: flex-start;\">\n<section style=\"color: rgb(106, 106, 106);font-size: 15px;text-align: left;\">\n<p style=\"text-align: justify;text-wrap: wrap;\"><span style=\"color: rgb(203, 47, 21);\">\u56fe 2.5.9\uff1a<\/span><span style=\"text-align: left;\">\u79c0\u4e3d\u9690\u6746\u7ebf\u866b\u7684\u8fdb\u98df\u884c\u4e3a\u53d6\u51b3\u4e8e\u7f16\u7801\u795e\u7ecf\u80bd\u53d7\u4f53\u7684\u57fa\u56e0\u6d3b\u6027\u3002\u5728\u4e00\u4e2a\u54c1\u7cfb\u4e2d\uff0c\u4e2a\u4f53\u8815\u866b\u5728\u5b64\u7acb\u72b6\u6001\u4e0b\u5355\u72ec\u89c5\u98df\uff08\u5de6\u56fe\uff09\uff0c\u800c\u5728\u53e6\u4e00\u4e2a\u54c1\u7cfb\u4e2d\uff0c\u4e2a\u4f53\u5219\u503e\u5411\u4e8e\u805a\u96c6\u5728\u4e00\u8d77\u89c5\u98df\u3002\u8fd9\u79cd\u5dee\u5f02\u53ef\u4ee5\u901a\u8fc7\u795e\u7ecf\u80bd\u53d7\u4f53\u57fa\u56e0\u4e2d\u7684\u5355\u4e2a\u6c28\u57fa\u9178\u66ff\u6362\u6765\u89e3\u91ca\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin-top: 10px;margin-bottom: 10px;\">\n<section style=\"display: inline-block;width: 100%;border-width: 2px;border-style: dashed;border-color: rgb(164, 172, 181);padding: 10px;background-color: rgb(238, 249, 255);border-radius: 11.2px;overflow: hidden;\">\n<section style=\"color: rgb(0, 0, 0);\">\n<p style=\"text-wrap: wrap;\">\u795e\u7ecf\u80bd\u53d7\u4f53\u4e5f\u4e0e\u54fa\u4e73\u52a8\u7269\u793e\u4f1a\u884c\u4e3a\u7684\u8c03\u8282\u6709\u5173\u3002\u795e\u7ecf\u80bd\u50ac\u4ea7\u7d20\u548c\u52a0\u538b\u7d20\u523a\u6fc0\u54fa\u4e73\u52a8\u7269\u7684\u4eb2\u548c\u884c\u4e3a\uff0c\u4f8b\u5982\u914d\u5bf9\u7ed3\u5408\u548c\u7236\u6bcd\u4e0e\u540e\u4ee3\u7684\u7ed3\u5408\u3002\u5728\u5c0f\u9f20\u4e2d\uff0c\u50ac\u4ea7\u7d20\u5bf9\u793e\u4f1a\u8ba4\u77e5\u662f\u5fc5\u9700\u7684\uff0c\u5373\u8bc6\u522b\u719f\u6089\u7684\u4e2a\u4f53\u3002\u50ac\u4ea7\u7d20\u548c\u52a0\u538b\u7d20\u5728\u8349\u539f\u7530\u9f20\u4e2d\u5df2\u88ab\u6df1\u5165\u7814\u7a76\uff0c\u8fd9\u4e9b\u556e\u9f7f\u52a8\u7269\u4f1a\u5f62\u6210\u6301\u4e45\u7684\u914d\u5bf9\u5173\u7cfb\u6765\u629a\u517b\u5b83\u4eec\u7684\u5e7c\u5d3d\u3002\u5728\u4ea4\u914d\u671f\u95f4\uff0c\u96cc\u6027\u8349\u539f\u7530\u9f20\u5927\u8111\u4e2d\u91ca\u653e\u7684\u50ac\u4ea7\u7d20\u4f1a\u4fc3\u8fdb\u914d\u5bf9\u5173\u7cfb\u7684\u5f62\u6210\u3002\u540c\u6837\uff0c\u5728\u4ea4\u914d\u671f\u95f4\uff0c\u96c4\u6027\u8349\u539f\u7530\u9f20\u5927\u8111\u4e2d\u91ca\u653e\u7684\u52a0\u538b\u7d20\u4e5f\u4f1a\u4fc3\u8fdb\u914d\u5bf9\u5173\u7cfb\u548c\u7236\u6027\u884c\u4e3a\u7684\u5f62\u6210\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin-top: 10px;margin-bottom: 10px;\">\n<section style=\"display: inline-block;width: 100%;border-width: 2px;border-style: dashed;border-color: rgb(164, 172, 181);padding: 10px;background-color: rgb(238, 249, 255);border-radius: 11.2px;overflow: hidden;\">\n<section style=\"color: rgb(0, 0, 0);\">\n<p style=\"text-wrap: wrap;\">\u4e0d\u540c\u54fa\u4e73\u52a8\u7269\u7269\u79cd\u4e4b\u95f4\u7684\u914d\u5bf9\u5173\u7cfb\u5f3a\u5ea6\u5b58\u5728\u663e\u8457\u5dee\u5f02\u3002\u96c4\u6027\u8349\u539f\u7530\u9f20\u4e0e\u96cc\u6027\u5efa\u7acb\u957f\u671f\u914d\u5bf9\u5173\u7cfb\uff0c\u5e76\u5e2e\u52a9\u629a\u517b\u540e\u4ee3\uff0c\u56e0\u6b64\u88ab\u63cf\u8ff0\u4e3a\u4e00\u592b\u4e00\u59bb\u5236\u3002\u800c\u4e0e\u5176\u5bc6\u5207\u76f8\u5173\u7684\u96c4\u6027\u5c71\u5730\u7530\u9f20\u5219\u8868\u73b0\u4e3a\u5e7f\u6cdb\u4ea4\u914d\uff0c\u5e76\u4e14\u4e0d\u53c2\u4e0e\u629a\u517b\u540e\u4ee3\u7684\u884c\u4e3a\u3002\u8fd9\u4e9b\u7269\u79cd\u95f4\u96c4\u6027\u884c\u4e3a\u7684\u5dee\u5f02\u4e0e\u5927\u8111\u4e2d\u8840\u7ba1\u52a0\u538b\u7d20\u53d7\u4f53\u7684\u8868\u8fbe\u6c34\u5e73\u6709\u5173\u3002\u5728\u8349\u539f\u7530\u9f20\u4e2d\uff0c\u8840\u7ba1\u52a0\u538b\u7d20\u53d7\u4f53\u5728\u8179\u4fa7\u82cd\u767d\u7403\u8fd9\u4e00\u7279\u5b9a\u5927\u8111\u533a\u57df\u4e2d\u9ad8\u5ea6\u8868\u8fbe\uff08\u89c1<span style=\"color: rgb(203, 47, 21);\">\u56fe2.5.10<\/span>\uff09\uff0c\u800c\u5728\u5c71\u5730\u7530\u9f20\u4e2d\uff0c\u8fd9\u4e00\u533a\u57df\u7684\u8868\u8fbe\u6c34\u5e73\u5219\u4f4e\u5f97\u591a\uff0c\u5c3d\u7ba1\u5176\u4ed6\u5927\u8111\u533a\u57df\u7684\u8868\u8fbe\u6c34\u5e73\u8f83\u9ad8\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin-top: 10px;margin-bottom: 10px;\">\n<section style=\"display: inline-block;width: 100%;border-width: 2px;border-style: dashed;border-color: rgb(164, 172, 181);padding: 10px;background-color: rgb(238, 249, 255);border-radius: 11.2px;overflow: hidden;\">\n<section style=\"color: rgb(0, 0, 0);\">\n<p style=\"text-wrap: wrap;\">\u50ac\u4ea7\u7d20\u548c\u52a0\u538b\u7d20\u53ca\u5176\u53d7\u4f53\u7684\u91cd\u8981\u6027\u5df2\u901a\u8fc7\u5c0f\u9f20\u7684\u53cd\u5411\u9057\u4f20\u5b66\u7814\u7a76\u5f97\u5230\u4e86\u8bc1\u5b9e\u548c\u6269\u5c55\u3002\u8fd9\u4e9b\u7814\u7a76\u6bd4\u5728\u7530\u9f20\u4e0a\u7684\u7814\u7a76\u66f4\u5bb9\u6613\u8fdb\u884c\u57fa\u56e0\u64cd\u4f5c\u3002\u4f8b\u5982\uff0c\u5c06\u8349\u539f\u7530\u9f20\u7684\u8840\u7ba1\u52a0\u538b\u7d20\u53d7\u4f53\u57fa\u56e0\u5f15\u5165\u884c\u4e3a\u66f4\u7c7b\u4f3c\u5c71\u5730\u7530\u9f20\u7684\u96c4\u6027\u5c0f\u9f20\u4f53\u5185\uff0c\u7ed3\u679c\u663e\u793a\uff0c\u8fd9\u4e9b\u5c0f\u9f20\u5728\u8179\u4fa7\u82cd\u767d\u7403\u4e2d\u7684\u8840\u7ba1\u52a0\u538b\u7d20\u53d7\u4f53\u8868\u8fbe\u589e\u52a0\uff0c\u96c4\u6027\u5c0f\u9f20\u5bf9\u96cc\u6027\u7684\u4eb2\u548c\u884c\u4e3a\u4e5f\u968f\u4e4b\u589e\u5f3a\u3002\u56e0\u6b64\uff0c\u4e0d\u540c\u7269\u79cd\u95f4\u52a0\u538b\u7d20\u53d7\u4f53\u8868\u8fbe\u6a21\u5f0f\u7684\u5dee\u5f02\u53ef\u80fd\u662f\u5bfc\u81f4\u793e\u4f1a\u884c\u4e3a\u5dee\u5f02\u7684\u5173\u952e\u56e0\u7d20\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin-top: 10px;margin-bottom: 10px;\">\n<section style=\"display: inline-block;width: 100%;border-width: 2px;border-style: dashed;border-color: rgb(164, 172, 181);padding: 10px;background-color: rgb(238, 249, 255);border-radius: 11.2px;overflow: hidden;\">\n<section style=\"color: rgb(0, 0, 0);\">\n<p style=\"text-wrap: wrap;\">\u5bf9\u4e0d\u540c\u556e\u9f7f\u52a8\u7269\u4e2d\u8840\u7ba1\u52a0\u538b\u7d20\u53d7\u4f53\u7684\u5206\u6790\u4e3a\u6211\u4eec\u63d0\u4f9b\u4e86\u5173\u4e8e\u57fa\u56e0\u548c\u884c\u4e3a\u5728\u8fdb\u5316\u8fc7\u7a0b\u4e2d\u5982\u4f55\u53d1\u751f\u53d8\u5316\u7684\u91cd\u8981\u89c1\u89e3\u3002\u8179\u4fa7\u524d\u8111V1a\u52a0\u538b\u7d20\u53d7\u4f53\u8868\u8fbe\u6a21\u5f0f\u7684\u8fdb\u5316\u6539\u53d8\u4e86\u795e\u7ecf\u56de\u8def\u7684\u6d3b\u52a8\uff0c\u5c06\u8179\u4fa7\u524d\u8111\u7684\u529f\u80fd\u4e0e\u4ea4\u914d\u65f6\u6fc0\u6d3b\u7684\u52a0\u538b\u7d20\u5206\u6ccc\u795e\u7ecf\u5143\u7684\u529f\u80fd\u8054\u7cfb\u8d77\u6765\uff0c\u8fdb\u800c\u6539\u53d8\u4e86\u793e\u4f1a\u884c\u4e3a\u3002<\/p>\n<p style=\"text-wrap: wrap;\">\u867d\u7136\u50ac\u4ea7\u7d20\u548c\u52a0\u538b\u7d20\u5728\u4eba\u7c7b\u793e\u4f1a\u884c\u4e3a\u4e2d\u7684\u4f5c\u7528\u5c1a\u672a\u5b8c\u5168\u660e\u786e\uff0c\u4f46\u5b83\u4eec\u5728\u54fa\u4e73\u52a8\u7269\u4e2d\u5bf9\u914d\u5bf9\u7ed3\u5408\u548c\u629a\u517b\u540e\u4ee3\u7684\u6838\u5fc3\u4f5c\u7528\u6697\u793a\uff0c\u8fd9\u4e9b\u5206\u5b50\u53ef\u80fd\u5728\u4eba\u7c7b\u4e2d\u4e5f\u53d1\u6325\u7c7b\u4f3c\u7684\u4f5c\u7528\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-imgfileid=\"308774077\" data-ratio=\"0.605080831408776\" data-s=\"300,640\"  data-type=\"png\" data-w=\"866\" style=\"vertical-align: middle;width: 100%;\" src=\"http:\/\/dh.oncolab.cn\/wp-content\/uploads\/2025\/01\/wxsync-2025-01-6b7ef6d5744d300dc64cb32b3475fb99.png\"  \/><\/section>\n<\/section>\n<section style=\"text-align: right;justify-content: flex-end;margin-right: 0%;margin-bottom: 10px;margin-left: 0%;display: flex;flex-flow: row;\">\n<section style=\"display: inline-block;vertical-align: top;width: 30px;border-left: 2px solid rgb(51, 122, 183);border-bottom-left-radius: 0px;border-bottom: 2px solid rgb(51, 122, 183);border-bottom-right-radius: 0px;flex: 0 0 auto;height: auto;line-height: 1;align-self: flex-start;\">\n<section style=\"text-align: justify;\">\n<p style=\"text-wrap: wrap;\"><br  \/><\/p>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: top;width: 90%;flex: 0 0 auto;height: auto;padding-left: 8px;align-self: flex-start;\">\n<section style=\"color: rgb(106, 106, 106);font-size: 15px;text-align: left;\">\n<p style=\"text-align: justify;text-wrap: wrap;\"><span style=\"color: rgb(203, 47, 21);\">\u56fe 2.5.10\uff1a<\/span><span style=\"text-align: left;\">\u8840\u7ba1\u52a0\u538b\u7d20\u53d7\u4f53\u5728\u4e24\u79cd\u4eb2\u7f18\u5173\u7cfb\u5bc6\u5207\u7684\u556e\u9f7f\u52a8\u7269\u4e2d\u7684\u5206\u5e03\u5dee\u5f02\u3002<\/span><\/p>\n<p>A. \u5728\u5c71\u5730\u7530\u9f20\u7684\u5916\u4fa7\u9694\u6838\u4e2d\uff0c\u53d7\u4f53\u8868\u8fbe\u8f83\u9ad8\uff0c\u4f46\u5728\u8179\u4fa7\u82cd\u767d\u7403\u4e2d\u8868\u8fbe\u8f83\u4f4e\uff0c\u8fd9\u79cd\u6a21\u5f0f\u4e0d\u5f62\u6210\u914d\u5bf9\u952e\u3002<\/p>\n<p>B. \u5728\u4e00\u592b\u4e00\u59bb\u5236\u7684\u8349\u539f\u7530\u9f20\u4e2d\uff0c\u53d7\u4f53\u5728\u8179\u4fa7\u82cd\u767d\u7403\u4e2d\u7684\u8868\u8fbe\u8f83\u9ad8\u3002\u53d7\u4f53\u5728\u8179\u4fa7\u82cd\u767d\u7403\u4e2d\u7684\u8868\u8fbe\u4f7f\u8840\u7ba1\u52a0\u538b\u7d20\u80fd\u591f\u5c06\u793e\u4f1a\u8ba4\u77e5\u901a\u8def\u4e0e\u5956\u8d4f\u901a\u8def\u8fde\u63a5\u8d77\u6765\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section data-style=\"margin-bottom: 0px; outline: 0px; letter-spacing: 0.544px; text-wrap: wrap; background-color: rgb(255, 255, 255); color: rgb(53, 53, 53); text-align: start; font-family: -apple-system, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif; font-size: 16px; visibility: visible;\" class=\"js_darkmode__52\" style=\"-webkit-tap-highlight-color: transparent;margin-bottom: 0px;outline: 0px;background-color: rgb(255, 255, 255);color: rgb(53, 53, 53);letter-spacing: 0.544px;text-wrap: wrap;text-align: start;font-family: -apple-system, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;font-size: 16px;visibility: visible;\">\n<section style=\"-webkit-tap-highlight-color: transparent;outline: 0px;visibility: visible;\">\n<section style=\"-webkit-tap-highlight-color: transparent;outline: 0px;visibility: visible;\">\n<section powered-by=\"xiumi.us\" style=\"-webkit-tap-highlight-color: transparent;margin-top: 10px;margin-bottom: 10px;outline: 0px;text-align: center;visibility: visible;\">\n<p style=\"-webkit-tap-highlight-color: transparent;margin-bottom: 10px;outline: 0px;\"><span data-style=\"outline: 0px; color: rgb(0, 0, 0); font-family: -apple-system-font, system-ui, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif; font-size: 12px; letter-spacing: 0.544px;\" class=\"js_darkmode__53\" style=\"-webkit-tap-highlight-color: transparent;outline: 0px;color: rgb(0, 0, 0);font-family: -apple-system-font, system-ui, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;font-size: 12px;letter-spacing: 0.544px;\">\u672c\u6587\u7ffb\u8bd1\u6574\u7406\u81eaPrinciples of Neural Science, Sixth Edition\uff0c\u7ffb\u8bd1\u521d\u7a3f\u6765\u81ea\u4e8eGitHub\/OpenHUTB\uff0c\u672c\u516c\u4f17\u53f7\u8fdb\u884c\u8fdb\u4e00\u6b65\u6821\u5bf9\u6392\u7248\u540e\u53d1\u5e03\uff0c\u4ec5\u7528\u4e8e\u5b66\u4e60\u4ea4\u6d41\u4f7f\u7528\uff0c\u5982\u9700\u8d2d\u4e70\u539f\u7248\u4e66\u7c4d\u53ef\u70b9\u51fb\u9605\u8bfb\u539f\u6587\u8d2d\u4e70\u3002<\/span><br data-filtered=\"filtered\" style=\"-webkit-tap-highlight-color: transparent;outline: 0px;\"  \/><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p data-style=\"margin-bottom: 0px; outline: 0px; letter-spacing: 0.544px; text-wrap: wrap; background-color: rgb(255, 255, 255); color: rgb(53, 53, 53); font-size: 14px; font-family: -apple-system, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif; text-align: center;\" class=\"js_darkmode__54\" style=\"-webkit-tap-highlight-color: transparent;margin-bottom: 0px;outline: 0px;background-color: rgb(255, 255, 255);color: rgb(53, 53, 53);letter-spacing: 0.544px;text-wrap: wrap;font-size: 14px;font-family: -apple-system, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;text-align: center;\"><br data-filtered=\"filtered\" style=\"-webkit-tap-highlight-color: transparent;outline: 0px;letter-spacing: 0.544px;\"  \/><\/p>\n<p data-style=\"margin-bottom: 0px; outline: 0px; letter-spacing: 0.544px; text-wrap: wrap; background-color: rgb(255, 255, 255); color: rgb(53, 53, 53); font-size: 14px; font-family: -apple-system, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif; text-align: center;\" class=\"js_darkmode__55\" style=\"-webkit-tap-highlight-color: transparent;margin-bottom: 0px;outline: 0px;background-color: rgb(255, 255, 255);color: rgb(53, 53, 53);letter-spacing: 0.544px;text-wrap: wrap;font-size: 14px;font-family: -apple-system, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;text-align: center;\"><span data-style=\"outline: 0px; color: rgb(0, 0, 0); font-size: 12px;\" class=\"js_darkmode__56\" style=\"-webkit-tap-highlight-color: transparent;outline: 0px;color: rgb(0, 0, 0);font-size: 12px;\">\u2014&nbsp;THE&nbsp;&nbsp;END&nbsp;\u2014<\/span><\/p>\n<p data-style=\"margin-bottom: 0px; outline: 0px; letter-spacing: 0.544px; text-wrap: wrap; background-color: rgb(255, 255, 255); color: rgb(53, 53, 53); font-size: 14px; font-family: -apple-system, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif; text-align: center;\" class=\"js_darkmode__57\" style=\"-webkit-tap-highlight-color: transparent;margin-bottom: 0px;outline: 0px;background-color: rgb(255, 255, 255);color: rgb(53, 53, 53);letter-spacing: 0.544px;text-wrap: wrap;font-size: 14px;font-family: -apple-system, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;text-align: center;\"><br data-filtered=\"filtered\" style=\"-webkit-tap-highlight-color: transparent;outline: 0px;\"  \/><\/p>\n<p data-style=\"margin-bottom: 0px; outline: 0px; letter-spacing: 0.544px; text-wrap: wrap; background-color: rgb(255, 255, 255); color: rgb(53, 53, 53); font-size: 14px; font-family: -apple-system, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif; text-align: center; line-height: 1.6em;\" class=\"js_darkmode__58\" style=\"-webkit-tap-highlight-color: transparent;margin-bottom: 0px;outline: 0px;background-color: rgb(255, 255, 255);color: rgb(53, 53, 53);letter-spacing: 0.544px;text-wrap: wrap;font-size: 14px;font-family: -apple-system, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;text-align: center;line-height: 1.6em;\"><span style=\"-webkit-tap-highlight-color: transparent;outline: 0px;color: rgb(136, 136, 136);font-size: 12px;\">\u6765\u6e90&nbsp;|&nbsp;Principles of Neural Science, Sixth Edition<\/span><\/p>\n<p data-style=\"margin-bottom: 0px; outline: 0px; letter-spacing: 0.544px; text-wrap: wrap; background-color: rgb(255, 255, 255); color: rgb(53, 53, 53); font-size: 14px; font-family: -apple-system, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif; text-align: center; line-height: 1.6em;\" class=\"js_darkmode__59\" style=\"-webkit-tap-highlight-color: transparent;margin-bottom: 0px;outline: 0px;background-color: rgb(255, 255, 255);color: rgb(53, 53, 53);letter-spacing: 0.544px;text-wrap: wrap;font-size: 14px;font-family: -apple-system, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;text-align: center;line-height: 1.6em;\"><span style=\"-webkit-tap-highlight-color: transparent;outline: 0px;color: rgb(136, 136, 136);font-size: 12px;letter-spacing: 0.54px;\">\u56fe\u6587\u6392\u7248<span data-style=\"color: rgb(136, 136, 136); font-family: -apple-system, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif; font-size: 12px; letter-spacing: 0.54px; text-align: center; text-wrap: wrap; background-color: rgb(255, 255, 255);\" style=\"-webkit-tap-highlight-color: transparent;outline: 0px;letter-spacing: 0.54px;\">&nbsp;| \u674e\u828b\u5cad<\/span><\/span><\/p>\n<p data-style=\"margin-bottom: 0px; outline: 0px; letter-spacing: 0.544px; text-wrap: wrap; background-color: rgb(255, 255, 255); color: rgb(53, 53, 53); font-size: 14px; font-family: -apple-system, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif; text-align: center; line-height: 1.6em;\" class=\"js_darkmode__60\" style=\"-webkit-tap-highlight-color: transparent;margin-bottom: 0px;outline: 0px;background-color: rgb(255, 255, 255);color: rgb(53, 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0px;\">\u514d\u75ab\u5b66\u62fe\u9057\u7cfb\u5217<\/span><\/a><\/p>\n<p style=\"-webkit-tap-highlight-color: transparent;outline: 0px;visibility: visible;\"><a target=\"_blank\" href=\"https:\/\/mp.weixin.qq.com\/mp\/appmsgalbum?action=getalbum&amp;__biz=MzAwMDUzNTIxNA==&amp;scene=1&amp;album_id=2018077716062715908&amp;count=3#wechat_redirect\" textvalue=\"\u80bf\u7624\u514d\u75ab\u5b66\u7cfb\u5217\" linktype=\"text\" imgurl=\"\" imgdata=\"null\" tab=\"innerlink\" data-linktype=\"2\" data-style=\"cursor: pointer; font-family: system-ui, -apple-system, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif; letter-spacing: 0.544px; font-size: 17px; outline: 0px; color: rgb(2, 30, 170);\" class=\"js_darkmode__74\" style=\"outline: 0px;color: rgb(2, 30, 170);cursor: pointer;font-family: system-ui, -apple-system, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, 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16px; letter-spacing: 0.544px; color: rgb(2, 30, 170);\" class=\"js_darkmode__76\" style=\"outline: 0px;color: rgb(2, 30, 170);cursor: default;letter-spacing: 0.544px;\" rel=\"noopener\"><span data-style=\"outline: 0px; font-size: 16px; letter-spacing: 0.544px; color: rgb(2, 30, 170);\" class=\"js_darkmode__77\" style=\"-webkit-tap-highlight-color: transparent;outline: 0px;letter-spacing: 0.544px;\">\u795e\u7ecf\u79d1\u5b66\u539f\u7406\u7cfb\u5217<\/span><\/a><\/p>\n<p style=\"-webkit-tap-highlight-color: transparent;outline: 0px;visibility: visible;\"><a target=\"_blank\" href=\"https:\/\/mp.weixin.qq.com\/mp\/appmsgalbum?action=getalbum&amp;__biz=MzAwMDUzNTIxNA==&amp;scene=1&amp;album_id=2822922341205737475&amp;count=3#wechat_redirect\" textvalue=\"ACIR\u6587\u732e\u901f\u9012\" linktype=\"text\" imgurl=\"\" imgdata=\"null\" tab=\"innerlink\" data-linktype=\"2\" data-style=\"cursor: pointer; font-family: system-ui, -apple-system, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif; letter-spacing: 0.544px; font-size: 17px; outline: 0px; color: rgb(2, 30, 170);\" class=\"js_darkmode__78\" style=\"outline: 0px;color: rgb(2, 30, 170);cursor: pointer;font-family: system-ui, -apple-system, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;letter-spacing: 0.544px;font-size: 17px;\" rel=\"noopener\"><span data-style=\"outline: 0px; color: rgb(2, 30, 170);\" class=\"js_darkmode__79\" style=\"-webkit-tap-highlight-color: transparent;outline: 0px;\">ACIR\u6587\u732e\u901f\u9012<\/span><\/a><\/p>\n<p style=\"-webkit-tap-highlight-color: transparent;outline: 0px;visibility: visible;\"><a target=\"_blank\" href=\"https:\/\/mp.weixin.qq.com\/mp\/appmsgalbum?action=getalbum&amp;__biz=MzAwMDUzNTIxNA==&amp;scene=1&amp;album_id=1564295698236358662&amp;count=3#wechat_redirect\" textvalue=\"SCI\u8bba\u6587\u4f5c\u56fe\" linktype=\"text\" imgurl=\"\" imgdata=\"null\" tab=\"innerlink\" data-linktype=\"2\" data-style=\"cursor: pointer; font-family: system-ui, -apple-system, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif; letter-spacing: 0.544px; font-size: 17px; outline: 0px; color: rgb(2, 30, 170);\" class=\"js_darkmode__80\" style=\"outline: 0px;color: rgb(2, 30, 170);cursor: pointer;font-family: system-ui, -apple-system, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;letter-spacing: 0.544px;font-size: 17px;\" rel=\"noopener\"><span data-style=\"outline: 0px; color: rgb(2, 30, 170);\" class=\"js_darkmode__81\" style=\"-webkit-tap-highlight-color: transparent;outline: 0px;\">SCI\u8bba\u6587\u4f5c\u56fe<\/span><\/a><\/p>\n<p style=\"-webkit-tap-highlight-color: transparent;outline: 0px;visibility: visible;\"><a target=\"_blank\" href=\"https:\/\/mp.weixin.qq.com\/mp\/appmsgalbum?action=getalbum&amp;__biz=MzAwMDUzNTIxNA==&amp;scene=1&amp;album_id=1564293167342993409&amp;count=3#wechat_redirect\" textvalue=\"SCI\u8bba\u6587\u5199\u4f5c\u53ca\u6295\u7a3f\" linktype=\"text\" imgurl=\"\" imgdata=\"null\" tab=\"innerlink\" data-linktype=\"2\" data-style=\"cursor: pointer; font-family: system-ui, -apple-system, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif; letter-spacing: 0.544px; font-size: 17px; outline: 0px; color: rgb(2, 30, 170);\" class=\"js_darkmode__82\" style=\"outline: 0px;color: rgb(2, 30, 170);cursor: pointer;font-family: system-ui, -apple-system, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;letter-spacing: 0.544px;font-size: 17px;\" rel=\"noopener\"><span data-style=\"outline: 0px; color: rgb(2, 30, 170);\" class=\"js_darkmode__83\" style=\"-webkit-tap-highlight-color: transparent;outline: 0px;\">SCI\u8bba\u6587\u5199\u4f5c\u53ca\u6295\u7a3f<\/span><\/a><\/p>\n<p style=\"-webkit-tap-highlight-color: transparent;outline: 0px;visibility: visible;\"><a target=\"_blank\" href=\"https:\/\/mp.weixin.qq.com\/mp\/appmsgalbum?action=getalbum&amp;__biz=MzAwMDUzNTIxNA==&amp;scene=1&amp;album_id=1894714083283615746&amp;count=3#wechat_redirect\" textvalue=\"\u751f\u4fe1\u5165\u95e8\u5b66\u4e60\u7b14\u8bb0\" linktype=\"text\" imgurl=\"\" imgdata=\"null\" tab=\"innerlink\" data-linktype=\"2\" data-style=\"cursor: pointer; font-family: system-ui, -apple-system, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif; letter-spacing: 0.544px; font-size: 17px; outline: 0px; color: rgb(2, 30, 170);\" class=\"js_darkmode__84\" style=\"outline: 0px;color: rgb(2, 30, 170);cursor: pointer;font-family: system-ui, -apple-system, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;letter-spacing: 0.544px;font-size: 17px;\" rel=\"noopener\"><span data-style=\"outline: 0px; color: rgb(2, 30, 170);\" class=\"js_darkmode__85\" style=\"-webkit-tap-highlight-color: transparent;outline: 0px;\">\u751f\u4fe1\u5165\u95e8\u5b66\u4e60\u7b14\u8bb0<\/span><\/a><\/p>\n<p style=\"-webkit-tap-highlight-color: transparent;outline: 0px;visibility: visible;\"><a target=\"_blank\" href=\"https:\/\/mp.weixin.qq.com\/s?__biz=MzAwMDUzNTIxNA==&amp;mid=2456254175&amp;idx=1&amp;sn=d302a786f8fea3868ee719195418af61&amp;scene=21#wechat_redirect\" textvalue=\"R\u8bed\u8a00\u57fa\u7840\u4e0e\u5355\u7ec6\u80de\u5206\u6790\u5b9e\u6218\u89c6\u9891\u8bfe\u7a0b\" linktype=\"text\" imgurl=\"\" imgdata=\"null\" tab=\"innerlink\" data-linktype=\"2\" data-style=\"cursor: pointer; font-family: system-ui, -apple-system, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif; letter-spacing: 0.544px; font-size: 17px; outline: 0px; color: rgb(2, 30, 170);\" class=\"js_darkmode__86\" style=\"outline: 0px;color: rgb(2, 30, 170);cursor: pointer;font-family: system-ui, -apple-system, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;letter-spacing: 0.544px;font-size: 17px;\" rel=\"noopener\"><span data-style=\"outline: 0px; color: rgb(2, 30, 170);\" class=\"js_darkmode__87\" style=\"-webkit-tap-highlight-color: transparent;outline: 0px;\">R\u8bed\u8a00\u57fa\u7840\u4e0e\u5355\u7ec6\u80de\u5206\u6790\u5b9e\u6218\u89c6\u9891\u8bfe\u7a0b<\/span><\/a><\/p>\n<p style=\"-webkit-tap-highlight-color: transparent;outline: 0px;visibility: visible;\"><a target=\"_blank\" href=\"https:\/\/mp.weixin.qq.com\/mp\/appmsgalbum?action=getalbum&amp;__biz=MzAwMDUzNTIxNA==&amp;scene=1&amp;album_id=1564291300860936193&amp;count=3#wechat_redirect\" textvalue=\"\u751f\u7269\u5b66\u5b9e\u9a8c\u6280\u672f\u53ca\u5e38\u7528\u8f6f\u4ef6\" linktype=\"text\" imgurl=\"\" imgdata=\"null\" tab=\"innerlink\" data-linktype=\"2\" data-style=\"cursor: pointer; font-family: system-ui, -apple-system, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif; letter-spacing: 0.544px; font-size: 17px; outline: 0px; color: rgb(2, 30, 170);\" class=\"js_darkmode__88\" style=\"outline: 0px;color: rgb(2, 30, 170);cursor: pointer;font-family: system-ui, -apple-system, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;letter-spacing: 0.544px;font-size: 17px;\" rel=\"noopener\"><span data-style=\"outline: 0px; color: rgb(2, 30, 170);\" class=\"js_darkmode__89\" style=\"-webkit-tap-highlight-color: transparent;outline: 0px;\">\u751f\u7269\u5b66\u5b9e\u9a8c\u6280\u672f\u53ca\u5e38\u7528\u8f6f\u4ef6<\/span><\/a><\/p>\n<p style=\"-webkit-tap-highlight-color: transparent;outline: 0px;visibility: visible;\"><a target=\"_blank\" href=\"https:\/\/mp.weixin.qq.com\/mp\/appmsgalbum?action=getalbum&amp;__biz=MzAwMDUzNTIxNA==&amp;scene=1&amp;album_id=1564278007870046209&amp;count=3#wechat_redirect\" textvalue=\"\u5e38\u7528\u5b9e\u9a8c\u4eea\u5668\u7b80\u4ecb\u53ca\u64cd\u4f5c\u89c6\u9891\" linktype=\"text\" imgurl=\"\" imgdata=\"null\" tab=\"innerlink\" data-linktype=\"2\" style=\"outline: 0px;color: var(--weui-LINK);cursor: default;\" rel=\"noopener\"><span data-style=\"color: rgb(2, 30, 170);\" class=\"js_darkmode__90\" style=\"-webkit-tap-highlight-color: transparent;outline: 0px;color: rgb(2, 30, 170);\">\u5e38\u7528\u5b9e\u9a8c<\/span><span data-style=\"color: rgb(2, 30, 170);\" class=\"js_darkmode__91\" style=\"-webkit-tap-highlight-color: transparent;outline: 0px;color: rgb(2, 30, 170);\">\u4eea\u5668\u7b80\u4ecb\u53ca\u64cd\u4f5c\u89c6\u9891<\/span><\/a><span data-style=\"color: rgb(2, 30, 170);\" class=\"js_darkmode__92\" style=\"-webkit-tap-highlight-color: transparent;outline: 0px;color: rgb(2, 30, 170);\"><\/span><\/p>\n<p style=\"-webkit-tap-highlight-color: transparent;outline: 0px;visibility: visible;\"><a target=\"_blank\" href=\"https:\/\/mp.weixin.qq.com\/mp\/appmsgalbum?action=getalbum&amp;__biz=MzAwMDUzNTIxNA==&amp;scene=1&amp;album_id=1564286064490496000&amp;count=3#wechat_redirect\" textvalue=\"\u5e38\u7528\u7535\u8111\u8f6f\u4ef6\u4f7f\u7528\u6559\u7a0b\" linktype=\"text\" imgurl=\"\" imgdata=\"null\" tab=\"innerlink\" data-linktype=\"2\" style=\"outline: 0px;color: var(--weui-LINK);cursor: default;\" rel=\"noopener\"><span data-style=\"color: rgb(2, 30, 170);\" class=\"js_darkmode__93\" style=\"-webkit-tap-highlight-color: transparent;outline: 0px;color: rgb(2, 30, 170);\">\u5e38\u7528\u7535\u8111\u8f6f\u4ef6\u4f7f\u7528\u6559\u7a0b<\/span><\/a><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section powered-by=\"xiumi.us\" style=\"-webkit-tap-highlight-color: transparent;outline: 0px;\">\n<section mpa-from-tpl=\"t\" style=\"-webkit-tap-highlight-color: transparent;outline: 0px;letter-spacing: 0.544px;\">\n<section mpa-from-tpl=\"t\" style=\"-webkit-tap-highlight-color: transparent;outline: 0px;letter-spacing: 0.544px;\">\n<section mpa-from-tpl=\"t\" style=\"-webkit-tap-highlight-color: transparent;outline: 0px;\">\n<p data-style=\"outline: 0px; color: rgb(0, 0, 0); font-family: \u5fae\u8f6f\u96c5\u9ed1; font-size: 14px; letter-spacing: 0.54px; text-align: center;\" class=\"js_darkmode__94\" style=\"-webkit-tap-highlight-color: transparent;outline: 0px;color: rgb(0, 0, 0);font-family: \u5fae\u8f6f\u96c5\u9ed1;font-size: 14px;letter-spacing: 0.54px;text-align: center;\"><br data-filtered=\"filtered\" style=\"-webkit-tap-highlight-color: transparent;outline: 0px;\"  \/><\/p>\n<p data-style=\"outline: 0px; color: rgb(0, 0, 0); font-family: \u5fae\u8f6f\u96c5\u9ed1; font-size: 14px; letter-spacing: 0.54px; text-align: center;\" class=\"js_darkmode__95\" style=\"-webkit-tap-highlight-color: transparent;outline: 0px;color: rgb(0, 0, 0);font-family: \u5fae\u8f6f\u96c5\u9ed1;font-size: 14px;letter-spacing: 0.54px;text-align: center;\"><span style=\"-webkit-tap-highlight-color: transparent;outline: 0px;color: rgb(136, 136, 136);font-size: 12px;\"><img decoding=\"async\" class=\"rich_pages wxw-img js_darkmode__96\" data-cropselx1=\"0\" data-cropselx2=\"162\" data-cropsely1=\"0\" data-cropsely2=\"162\" data-fileid=\"308764751\" data-imgfileid=\"308774059\" data-ratio=\"1\" data-s=\"300,640\"  data-type=\"jpeg\" data-w=\"258\" style=\"-webkit-tap-highlight-color: transparent;outline: 0px;color: rgb(0, 0, 0);font-size: 14px;letter-spacing: 0.54px;display: initial;visibility: visible !important;width: 161.938px !important;\" width=\"162px\" src=\"http:\/\/dh.oncolab.cn\/wp-content\/uploads\/2025\/01\/wxsync-2025-01-a3f870d15872aa84f61f506373575ea1.webp\"  \/><\/span><\/p>\n<p data-style=\"outline: 0px; color: rgb(0, 0, 0); font-family: \u5fae\u8f6f\u96c5\u9ed1; font-size: 14px; letter-spacing: 0.54px; text-align: center;\" class=\"js_darkmode__97\" style=\"-webkit-tap-highlight-color: transparent;outline: 0px;color: rgb(0, 0, 0);font-family: \u5fae\u8f6f\u96c5\u9ed1;font-size: 14px;letter-spacing: 0.54px;text-align: center;\"><span style=\"-webkit-tap-highlight-color: transparent;outline: 0px;color: rgb(136, 136, 136);font-size: 12px;\">\u5173\u6ce8\u672c\u53f7~<\/span><br data-filtered=\"filtered\" style=\"-webkit-tap-highlight-color: transparent;outline: 0px;\"  \/><\/p>\n<p data-style=\"outline: 0px; color: rgb(0, 0, 0); font-family: \u5fae\u8f6f\u96c5\u9ed1; font-size: 14px; letter-spacing: 0.54px; text-align: center;\" class=\"js_darkmode__98\" style=\"-webkit-tap-highlight-color: transparent;outline: 0px;color: rgb(0, 0, 0);font-family: \u5fae\u8f6f\u96c5\u9ed1;font-size: 14px;letter-spacing: 0.54px;text-align: center;\"><br data-filtered=\"filtered\" style=\"-webkit-tap-highlight-color: transparent;outline: 0px;\"  \/><\/p>\n<p data-style=\"outline: 0px; color: rgb(0, 0, 0); font-family: \u5fae\u8f6f\u96c5\u9ed1; font-size: 14px; letter-spacing: 0.54px; text-align: center;\" class=\"js_darkmode__99\" style=\"-webkit-tap-highlight-color: transparent;outline: 0px;color: rgb(0, 0, 0);font-family: \u5fae\u8f6f\u96c5\u9ed1;font-size: 14px;letter-spacing: 0.54px;text-align: center;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-cropselx1=\"0\" data-cropselx2=\"155\" data-cropsely1=\"0\" data-cropsely2=\"155\" data-fileid=\"308764752\" data-imgfileid=\"308774061\" data-ratio=\"1\" data-s=\"300,640\"  data-type=\"jpeg\" data-w=\"613\" style=\"-webkit-tap-highlight-color: transparent;outline: 0px;display: initial;visibility: visible !important;width: 146.938px !important;\" width=\"147px\" src=\"http:\/\/dh.oncolab.cn\/wp-content\/uploads\/2025\/01\/wxsync-2025-01-c2a5f43f0a748896f9b68ee97ce727a0.webp\"><\/p>\n<p data-style=\"outline: 0px; color: rgb(0, 0, 0); font-family: \u5fae\u8f6f\u96c5\u9ed1; font-size: 14px; letter-spacing: 0.54px; text-align: center;\" class=\"js_darkmode__100\" style=\"-webkit-tap-highlight-color: transparent;outline: 0px;color: rgb(0, 0, 0);font-family: \u5fae\u8f6f\u96c5\u9ed1;font-size: 14px;letter-spacing: 0.54px;text-align: center;\"><span style=\"-webkit-tap-highlight-color: transparent;outline: 0px;color: rgb(136, 136, 136);font-size: 12px;\">\u52a0\u5165\u8bfb\u8005\u4ea4\u6d41\u7fa4~<\/span><\/p>\n<p style=\"-webkit-tap-highlight-color: transparent;outline: 0px;font-family: \u5fae\u8f6f\u96c5\u9ed1;letter-spacing: 0.54px;text-align: center;\"><span style=\"-webkit-tap-highlight-color: transparent;outline: 0px;color: rgb(136, 136, 136);font-size: 12px;\">\uff08\u6dfb\u52a0\u8bf7\u5907\u6ce8\u5355\u4f4d\u59d3\u540d\uff09<\/span><\/p>\n<p data-style=\"outline: 0px; color: rgb(0, 0, 0); font-family: \u5fae\u8f6f\u96c5\u9ed1; font-size: 14px; letter-spacing: 0.54px; text-align: center;\" class=\"js_darkmode__101\" style=\"-webkit-tap-highlight-color: transparent;outline: 0px;color: rgb(0, 0, 0);font-family: \u5fae\u8f6f\u96c5\u9ed1;font-size: 14px;letter-spacing: 0.54px;text-align: center;\"><br data-filtered=\"filtered\" style=\"-webkit-tap-highlight-color: transparent;outline: 0px;\"  \/><\/p>\n<p data-style=\"margin-bottom: 0em; outline: 0px; color: rgb(0, 0, 0); font-family: \u5fae\u8f6f\u96c5\u9ed1; font-size: 14px; letter-spacing: 0.54px; text-align: center;\" class=\"js_darkmode__102\" style=\"-webkit-tap-highlight-color: transparent;margin-bottom: 0em;outline: 0px;color: rgb(0, 0, 0);font-family: \u5fae\u8f6f\u96c5\u9ed1;font-size: 14px;letter-spacing: 0.54px;text-align: center;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-cropselx1=\"0\" data-cropselx2=\"147\" data-cropsely1=\"0\" data-cropsely2=\"147\" data-fileid=\"308764752\" data-imgfileid=\"308774060\" data-ratio=\"1\" data-s=\"300,640\"  data-type=\"png\" data-w=\"400\" style=\"-webkit-tap-highlight-color: transparent;outline: 0px;display: initial;visibility: visible !important;width: 171.938px !important;\" width=\"172px\" src=\"http:\/\/dh.oncolab.cn\/wp-content\/uploads\/2025\/01\/wxsync-2025-01-6a50d14645724dc35d2908cecde5989a.webp\"  \/><\/p>\n<p data-style=\"outline: 0px; color: rgb(0, 0, 0); font-family: \u5fae\u8f6f\u96c5\u9ed1; font-size: 14px; letter-spacing: 0.54px; text-align: center;\" class=\"js_darkmode__103\" style=\"-webkit-tap-highlight-color: transparent;outline: 0px;color: rgb(0, 0, 0);font-family: \u5fae\u8f6f\u96c5\u9ed1;font-size: 14px;letter-spacing: 0.54px;text-align: center;\"><span style=\"-webkit-tap-highlight-color: transparent;outline: 0px;color: rgb(136, 136, 136);font-size: 12px;\">\u52a0\u5165\u77e5\u8bc6\u661f\u7403~<\/span><\/p>\n<p data-style=\"outline: 0px; color: rgb(0, 0, 0); font-family: \u5fae\u8f6f\u96c5\u9ed1; font-size: 14px; letter-spacing: 0.54px; text-align: center;\" class=\"js_darkmode__104\" style=\"-webkit-tap-highlight-color: transparent;outline: 0px;color: rgb(0, 0, 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14px;letter-spacing: 0.54px;text-align: center;\"><br data-filtered=\"filtered\" style=\"-webkit-tap-highlight-color: transparent;outline: 0px;\"  \/><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p data-style=\"margin-right: 8px; margin-bottom: 0px; margin-left: 8px; outline: 0px; letter-spacing: 0.544px; text-wrap: wrap; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0); font-size: 16px; font-family: \u5fae\u8f6f\u96c5\u9ed1; widows: 1; text-align: right; line-height: 1.6em;\" class=\"js_darkmode__107\" style=\"-webkit-tap-highlight-color: transparent;margin-right: 8px;margin-bottom: 0px;margin-left: 8px;outline: 0px;background-color: rgb(255, 255, 255);color: rgb(0, 0, 0);letter-spacing: 0.544px;text-wrap: wrap;font-size: 16px;font-family: \u5fae\u8f6f\u96c5\u9ed1;widows: 1;text-align: right;line-height: 1.6em;\"><span data-style=\"outline: 0px; background-color: rgb(249, 237, 166); 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